Cellular schwannoma masquerading as malignant peripheral nerve sheath tumour: a diagnostic dilemma

Alam, Khursheed; Jain, Anshu; Misra, Aroonima; Khan, Aldrin

doi:10.1136/bcr-2012-008435

Cited by 5 publications

(9 citation statements)

References 12 publications

(6 reference statements)

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“…In our case, the mass had a homogeneous soft-tissue density, probably due to the high level of diffuse high cellularity. Interestingly, the mass had neither cystic areas nor calcifications, which instead are frequently encountered in schwannomas [44,48]. The enhancement pattern of schwannomas depends on the variation in the degree of cellularity; therefore, unlike our case, in which the enhancement refers to a moderately vascularized mass, a low cellularity with a diffuse edematous change may result in a minimal contrast enhancement [47].…”

Section: Discussionmentioning

confidence: 55%

Retroperitoneal cellular schwannoma (CS): a potential pitfall of malignancy. Report of a case and review of the literature

Longo¹,

Musumeci²,

Ferrara³

et al. 2014

J Histol Histopathol

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Cellular Schwannoma (CS) is a well-recognized morphological variant of schwannoma, which has been reported in many usual and unusual sites. We herein report a rare case of a bulky, retroperitoneal cellular schwannoma showing challenging radiological and morphological features. Due to large size and ill-defined margins at CT examination a malignant soft tissue tumor (sarcoma) was suggested. At histological examination high cellularity and co-existence of several growth patterns, such as fascicular, storiform and herringbone patterns, contributed to make difficult its recognition as schwannoma. The present case emphasizes the possibility that retroperitoneal CS can represent a potential diagnostic pitfall of malignancy. Awareness of the possibility that this unusual variant of schwannoma may occur in the retroperitoneum is crucial to avoid potential confusion with malignant tumors, especially when evaluating small biopsies.

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Section: Discussionmentioning

confidence: 55%

Retroperitoneal cellular schwannoma (CS): a potential pitfall of malignancy. Report of a case and review of the literature

Longo¹,

Musumeci²,

Ferrara³

et al. 2014

J Histol Histopathol

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“…Cellular schwannoma, a rare variant, typically presents as a Schwann cell fascicular proliferation with no Verocay bodies and the presence of high cellularity and increased mitotic figures 9 . Because of this increased mitoses and ability to cause bone erosion, it is often mistaken as a malignant peripheral nerve sheath tumor (MPNST), even though the clinical course is typically benign 22,23 . Diffuse positivity of S100 in schwannomas is helpful in differentiating between a schwannoma and MPNST.…”

Section: Discussionmentioning

confidence: 99%

Intravascular schwannoma: A review of a rare diagnosis

Dai

Cai

2020

J Cutan Pathol

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While schwannoma is one of the most common types of benign peripheral nerve tumors in adults, a very unique and specific variant of schwannoma, the intravascular variant, is exceedingly rare. There have only been three previously published cases of intravascular schwannomas. Here we describe a fourth case of an intravascular schwannoma in a 47‐year‐old man with an enlarging subcutaneous nodule on his posterior calf. This is the second case of an intravascular schwannoma contained within a vein. Also included is an overview of intravascular schwannomas, including a description and discussion of the histopathological diagnosis, differential diagnoses, and schwannoma variants.

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“…The presence of cellular whorls, perivascular and capsular lymphocytes and histocytes aggregates, and the absence of fascicles tend to the diagnosis of cellular schwannoma, while the presence of perivascular hypercellularity, extensive pleomorphism, high mitotic activity (> 10/10HPF), heterologous elements, and geographic areas of necrosis favor MPNST. [18] Other malignant spindle cell tumour (dermatofibrosarcoma protuerans, leiomyosarcoma, fibrosarcoma, synovial sarcoma, malignant fibrous histiocytoma) should be differentiated from cellular schwannoma. These tumours often present malignant histologic features, such as significant polymorphism, high mitotic activity (> 10/HPF) and necrosis.…”

Section: Discussionmentioning

confidence: 99%

Cellular schwannoma of the breast: A case report and review of literature

Zhang

Gao

Zhang

et al. 2018

CRCP

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Schwannoma of breast is a relatively uncommon disease characterized by painless and slow growing. We report a case of a 28-year-old female who present a mass of the right breast. Ultrasonography revealed a well-circumscribed and inhomogeneous hypoechoic mass under the skin of the breast. Then a biopsy and immunohistochemical analysis were performed. The results were suggestive for cellular schwannoma of breast. The tumour was removed successfully and the patient has been followed-up for six months with no evidence of recurrence. Cellular schwannoma is a rare benign neoplasm without metastasis. Distinction cellular schwannoma from other malignant tumours is very important. It is necessary to combine strict criteria on histological, immunohistochemical analysis, biological behavior, image examination and clinical features for the final diagnosis.

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Cellular schwannoma masquerading as malignant peripheral nerve sheath tumour: a diagnostic dilemma

Cited by 5 publications

References 12 publications

Retroperitoneal cellular schwannoma (CS): a potential pitfall of malignancy. Report of a case and review of the literature

Retroperitoneal cellular schwannoma (CS): a potential pitfall of malignancy. Report of a case and review of the literature

Intravascular schwannoma: A review of a rare diagnosis

Cellular schwannoma of the breast: A case report and review of literature

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