Cellular‐Scale Matrix Stiffness Gradient at Soft‐Hard Tissue Interfaces Regulates Immunophenotype of Mesenchymal Stem Cells
Hui Zhang,
Yufei Ma,
Wenya Shu
et al.
Abstract:Soft‐hard tissue interfaces are widespread in the human body, where matrix stiffness gradient at the cellular scale is a typical biophysical cue that cells experience. However, most studies have focused on the large‐scale matrix stiffness gradient that affected cell fate. It is still necessary to elucidate the impact of cellular‐scale matrix stiffness gradient on cell behavior and function, such as mesenchymal stem cell (MSC) immunoregulation. In this study, it is observed that stiffness gradient strength (SGS… Show more
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