Cellular Resistance to Viral Infection, With Particular Reference to Endogenous Interferon1

Wagner, Robert R.

doi:10.1128/mmbr.27.1.72-86.1963

Cited by 10 publications

(6 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Control viruses A18 and T2 demon-played a major role in the system described, strated consistent, although surprisingly slower, since interferon has been shown to be nonspecific rates of eclipse by the HeLa sublines tested. Thus, in viral interference and operative at the intraevidence of inhibition in the eclipse phase of cellular level (Ho, 1962;Wagner, 1963). Resultsof viral infection for superinfecting Coxsackie B1 the studies reported herein and of those preand B3 viruses by B5-carrier cells helps to explain viously recorded (Crowell and Syverton, 1961; the specific interference effects associated with Habel et al, 1958;Quersin-Thiry, 1958; Quersinthe system.…”

Section: Downloaded Frommentioning

confidence: 61%

Specific Viral Interference in Hela Cell Cultures Chronically Infected With Coxsackie B5 Virus

Crowell¹

1963

J Bacteriol

View full text Add to dashboard Cite

HeLa cell cultures chronically infected with Coxsackie B5 virus. J. Bacteriol. 86:517-526. 1963.-The presence of large amounts of Coxsackie B5 virus in culture fluids of a HeLa subline, serially propagated over a 3-year period, provided evidence for attainment of a viral carrier state. Human serum in the growth medium of carrier cultures appeared prerequisite for maintenance of a stable virus-cell equilibrium. Virus was eliminated from HeLa cells by addition of B5 antiserum to the growth medium, whereas subcultivation in calf serum medium resulted in cellular degeneration by virus. HeLa cells, chronically infected by B5 virus, retained normal morphology in monolayer cultures and were found preservable by freezing. Persistently infected HeLa cells formed colonies with high efficiency in a medium containing B5 antiserum, to provide evidence that the majority of cells in carrier populations were not fatally infected. The significance of occurrence of small and large plaque variants of B5 virus in the carrier system remains to be determined. Coxsackie B5-carrier cultures were found specifically resistant to superinfection by all members of Coxsackie group B. This resistance, due to viral interference, was not extended to three immunological types of Coxsackie group A, poliovirus types 1 to 3, adenovirus Ti, or vaccinia virus. Viral interference was found to be a consequence of altered surfaces of carrier cells, as reflected by decreased adsorption kinetics and cell penetration by 1 Presented in part as a preliminary report before the American Society for Microbiology, Kansas City, Mo., 7 May 1962.

show abstract

Section: Downloaded Frommentioning

confidence: 61%

Specific Viral Interference in Hela Cell Cultures Chronically Infected With Coxsackie B5 Virus

Crowell¹

1963

J Bacteriol

View full text Add to dashboard Cite

show abstract

“…Deficits in the humoral components of the innate immune system also predispose to infection [24][25][26][27][28][29]. Some important components include the complement and coagulation systems and substances such as lactoferrin, transferrin, lysozyme, interleukin-1, and interferons.…”

Section: Innate Immune System Adaptive Immune Systemmentioning

confidence: 99%

Epidemiology of Infections in Cancer Patients

Zembower

2014

Cancer Treatment and Research

126

123

View full text Add to dashboard Cite

Although major advances in the care of cancer patients over the past several decades have resulted in improved survival, infectious complications remain a significant cause of morbidity and mortality. To successfully identify, treat, and prevent infections, a comprehensive understanding of risk factors that predispose to infection and of commonly encountered pathogens is necessary. In addition, clinicians must keep abreast of the changing epidemiology of infections in this population. As therapeutic modalities continue to evolve, as established pathogens become increasingly drug resistant, and as new pathogens are discovered, successful management of infections will continue to present challenges in the years to come.

show abstract

“…Several investigators (1,6,7,10,17,22,23) have attempted to define the possible role of interferon in protecting against and in effecting recovery from viral infections. Collectively, their findings suggest that interferon may be an important factor of immunity during the early phases of viral infection before antibody immunity becomes expressed.…”

mentioning

confidence: 99%

Production of Interferon by Alveolar Macrophages

Acton

Myrvik

1966

J Bacteriol

View full text Add to dashboard Cite

Rabbit alveolar macrophages inoculated with parainfluenza-3 virus in vitro produce a viral inhibitor which possesses the properties of interferon. The interferon is nondialyzable, is stable at pH 4, is not sedimented at 100,000 x g, exhibits species specificity, and can passively protect other alveolar macrophages from infection with virulent rabbitpox virus. The possible significance of alveolar macrophage-produced interferon is discussed. In spite of increased interest in the interaction of viruses with the cells of the reticuloendothelial

show abstract

Cellular Resistance to Viral Infection, With Particular Reference to Endogenous Interferon1

Cited by 10 publications

References 28 publications

Specific Viral Interference in Hela Cell Cultures Chronically Infected With Coxsackie B5 Virus

Specific Viral Interference in Hela Cell Cultures Chronically Infected With Coxsackie B5 Virus

Epidemiology of Infections in Cancer Patients

Production of Interferon by Alveolar Macrophages

Contact Info

Product

Resources

About