Cellular proliferation/cytotoxicity and antimicrobial potentials of green synthesized silver nanoparticles (AgNPs) using Juniperus procera

Ibrahim, Essam H.; Kilany, Mona; Ghramh, Hamed A.; Khan, Khalid Ali; Islam, Saif Ul

doi:10.1016/j.sjbs.2018.08.014

Cited by 53 publications

(31 citation statements)

References 57 publications

(61 reference statements)

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“…Reduction in peak at 2925 cm −1 was seen in nanoparticles when compared to extract which signifies the involvement of proteins as reducing and capping agent. Earlier studies of IR spectra of biologically synthesized nanoparticles have shown the presence of biomolecules on their surface [13,22,23]. From the present study also it can be confirmed that the nanoparticles synthesized from PSC extract are capped with organic residues like proteins and amino acids and phenolic compounds, which are mainly involved in the reduction of metallic solutions.…”

Section: Synthesis and Characterization Of Pscaunps At Un-optimised Csupporting

confidence: 81%

“…Aqueous HAuCl 4 ·0.3H 2 O (1 mM) was prepared in deionized water and was added to the cell free extract of PSC in the ratio 1:9 and mixed, such that the concentration of PSC extract was 10%w/v. The mixture was maintained at a pH of 4.8 by using 0.1 N HNO 3 [12] and 1 ml of Triton X-100 (1 mM) was added [13], which acts as a protective agents and controls the size of synthesized nanoparticles [14]. The mixture was incubated at 25 °C at 100 rpm agitation and UV-Vis absorbance at 360-600 nm range was measured hourly interval for 7 h till constant readings were obtained.…”

Section: Synthesis Of Pscaunpsmentioning

confidence: 99%

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Two fold increase in synthesis of gold nanoparticles assisted by proteins and phenolic compounds in Pongamia seed cake extract: response surface methodology approach

et al. 2020

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The objective of the present study was to optimise the biosynthesis of gold nanoparticles using aqueous extract of Pongamia seed cake (PSC). Proteins, amino acids and phenolic compounds present in the PSC extract are responsible for reducing the metal precursor salt to nanoparticles. The levels of factors for optimisation of nanoparticles synthesis was evaluated using UV-Vis spectrophotometer by one factor at a time studies. Further factorial design was employed to study the significant effect of various parameters on the nanoparticles synthesis. The levels of two significant factors i.e. pH and concentration of PSC extract as obtained from factorial design were optimized further for maximum nanoparticle synthesis applying central composite design. The optimized conditions were found to be pH 3.6 and PSC extract concentration of 17.07% (w/v) at which an increase (OD at 530 nm = 1.3) in nanoparticle synthesis was observed as compared to un-optimized conditions (OD at 530 nm = 0.66). The model obtained on optimization was validated and it describes the nanoparticle synthesis aptly with an error between experimental and predicted values of just 1.15% with an R 2 of 0.985. It can be concluded that, RSM approach was found to be an efficient technique to optimize the reaction conditions, where a twofold increase in synthesis of small sized monodispersed gold nanoparticles was seen.Electronic supplementary material The online version of this article (https ://doi.

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Section: Synthesis and Characterization Of Pscaunps At Un-optimised Csupporting

confidence: 81%

Section: Synthesis Of Pscaunpsmentioning

confidence: 99%

Two fold increase in synthesis of gold nanoparticles assisted by proteins and phenolic compounds in Pongamia seed cake extract: response surface methodology approach

et al. 2020

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“…The antifungal potential was also established to be concentration-dependent, with a superior effect for the smaller particles (obtained by using 1 mM silver precursor) lines and the best efficiency observed for the leaf extract, followed by stem and root extracts. Ibrahim et al [16] obtained spherical and cubical nanoparticles For example, Mtambo et al [15] presented the phytosynthesis of silver nanoparticles (AgNPs) by using aqueous extracts obtained from different parts of Bidens pilosa L. 1753 (leaves, stems and roots), as well as different concentration of a metal salt precursor (1 and 2 mM). The lowest average diameters that were observed by the authors were 7.85 nm (leaf extract/1 mM silver salt) and 11.89 nm (root extract/2 mM silver salt).…”

Section: Antimicrobial Applicationsmentioning

confidence: 99%

“…The antifungal potential was also established to be concentration-dependent, with a superior effect for the smaller particles (obtained by using 1 mM silver precursor) lines and the best efficiency observed for the leaf extract, followed by stem and root extracts. Ibrahim et al [16] obtained spherical and cubical nanoparticles with larger dimensions (30-90 nm) by using African juniper leaf acetone extracts. Their antimicrobial assay (performed by measuring the inhibition zone in well-diffusion assay) revealed a superior effect of the NPs compared to the positive control (penicillin; 10 µg) against all lines (180%-350%), an effect to which the crude extract also contributes (with inhibition zones that were comparable to the positive control).…”

Section: Antimicrobial Applicationsmentioning

confidence: 99%

Phytosynthesized Metallic Nanoparticles—between Nanomedicine and Toxicology. A Brief Review of 2019′s Findings

et al. 2020

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Phytosynthesized nanoparticles represent a continuously increasing field of research, with numerous studies published each year. However, with the emerging interest in this area, the quality of the published works is also continuously increasing, switching from routine antioxidant or antimicrobial studies on trivial microbial lines to antibiotic-resistant strains or antitumoral studies. However, this increasing interest has not been not reflected in the studies regarding the toxicological effects of nanoparticles (NPs); this should be a subject of greatest interest, as the increasing administration of NPs in general (and phytosynthesized NPs in particular) could lead to their accumulation in the environment (soil, water and living organisms). The present review aims to present the most recent findings in the application of phytosynthesized NPs as antimicrobial and antitumoral agents, as well as the results regarding their toxicological potential.Materials 2020, 13, 574 2 of 32 in terms of their toxic potential towards target organisms (leading to their proposal as antimicrobial [4], antiviral [5] or cytogenotoxic agents [6]), their possible negative toxicity has not been thoroughly established. The present review aims to present the advances that have been recorded in the last year in the area of phytosynthesized nanoparticle applications and toxicity studies, as well to underline the shortcomings of the encountered approach. The literature review survey was performed on multiple databases (Scopus, Web of Science, ScienceDirect, SpringerLink, PubMed) and used the main keywords "nanoparticles" and "extract" (as the term "phytosynthesis" was not adopted by all the authors). From the returned results, only the works that were published in the last year (2019) were selected. Furthermore, a supplementary selection was performed by using keywords as "antimicrobial," "cytotoxicity," and "toxicology" (results presented in Figure 1). The results of this preliminary selection led to the return of approximately 1800 unique works (from all the databases). A preliminary validation was manually performed (by reading the keywords and abstract) in order to remove the "false-positive" results. The final validation was performed by reading the entire manuscript. The criteria for inclusion in the present review were: (i) the use of phytosynthesized nanoparticles that were obtained in the laboratory; (ii) the existence of analytical studies for the characterization of the nanoparticles; and (iii) in-depth applications reports. The review is structured in different chapters for each potential application that is related to the toxic effect of the metallic nanoparticles.

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“…All characterization methods for AgNPs prepared by honey samples and active biomolecules found in honey samples before and after the synthesis of AgNPs were done following the same methods and instruments described by Ibrahim, Kilany, Ghramh, Khan, and ul Islam (2018). …”

Section: Characterizationmentioning

confidence: 99%

Study of anticancer, antimicrobial, immunomodulatory, and silver nanoparticles production by Sidr honey from three different sources

Ghramh

Ibrahim

Kilany

2019

Food Science & Nutrition

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Sidr honey is used as food and medicine in many countries. Study of immunomodulatory and anticancer activity of Sidr honey did not tested before. The aim of this work was to study the anticancer activity and immunomodulatory as well as antimicrobial potential of Sidr honey and its synthesized silver nanoparticles (AgNPs). Sidr honey from three sources (two from Kingdom of Saudi Arabia (KSA) and one from Pakistan) was diluted to 20% and tested for its biological activities and to synthesize AgNPs. The results demonstrated that honeys could produce AgNPs (spherical shape), modulated the growth of normal splenic cells, and have antimicrobial activities. Sidr honey has anticancer activity against HepG2 but not Hela cells. Sidr honey can be used as antimicrobial agent, but can be used as anticancer agent with care as it stimulated cell growth of some lines (e.g., Hala) and inhibited another (e.g., HepG2).

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Cellular proliferation/cytotoxicity and antimicrobial potentials of green synthesized silver nanoparticles (AgNPs) using Juniperus procera

Abstract: Graphical abstract

Cited by 53 publications

References 57 publications

Two fold increase in synthesis of gold nanoparticles assisted by proteins and phenolic compounds in Pongamia seed cake extract: response surface methodology approach

Two fold increase in synthesis of gold nanoparticles assisted by proteins and phenolic compounds in Pongamia seed cake extract: response surface methodology approach

Phytosynthesized Metallic Nanoparticles—between Nanomedicine and Toxicology. A Brief Review of 2019′s Findings

Study of anticancer, antimicrobial, immunomodulatory, and silver nanoparticles production by Sidr honey from three different sources

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