Cellular Pharmacokinetics of BNCT Compounds and their Cellular Localization with EELS/ESI

Verrijk, R.; Huiskamp, R.; Smolders, I. J. H.; Begg, Adrian C.; Sorber, C. W. J.; Bruijn, W. C. de

doi:10.1007/978-1-4615-3408-2_21

Cited by 2 publications

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“…This method lacked energy resolution compared to STEM/EELS for boron . The boron can be detected by a threshold at Δ E = 188 eV in the energy loss spectrum, and the low endogenous boron concentration offers a low background signal and high sensitivity . EELS may be a perfect technique to obtain the intracellular localization of boron accurately, which provides a spatial resolution below one micron, approximately 0.5 μm, and it is independent of the boron isotope.…”

Section: Methods For Boron Microimaging and Analysismentioning

confidence: 99%

“…32 The boron can be detected by a threshold at ΔE = 188 eV in the energy loss spectrum, 85 and the low endogenous boron concentration offers a low background signal and high sensitivity. 86 EELS may be a perfect technique to obtain the intracellular localization of boron accurately, which provides a spatial resolution below one micron, approximately 0.5 μm, and it is independent of the boron isotope. Malac and his research team measured the limits of detection of boron concentration in carbon film and tobacco mosaic virus (TMV) by EELS and obtained a limit of 0.2% (2000 ppm) with 10% accuracy in the carbon matrix.…”

Section: Electron Energy Loss Spectroscopy (Eels)mentioning

confidence: 99%

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The Development of Boron Analysis and Imaging in Boron Neutron Capture Therapy (BNCT)

et al. 2022

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Boron neutron capture therapy (BNCT) is a selective biological targeted nuclide technique for cancer therapy. It has the following attractive features: good targeting, high effectiveness, and causes slight damage to surrounding healthy tissue compared with other traditional methods. It has been considered as one of the promising methods for the treatment of various cancers. Measuring 10B concentrations is vital for BNCT. However, the existing technology and equipment cannot satisfy the real-time and accurate measurement requirements, and more efficient methods are in demand. The development of methods and imaging applied in BNCT to help measure boron concentration is described in this review.

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Section: Methods For Boron Microimaging and Analysismentioning

confidence: 99%

Section: Electron Energy Loss Spectroscopy (Eels)mentioning

confidence: 99%

The Development of Boron Analysis and Imaging in Boron Neutron Capture Therapy (BNCT)

et al. 2022

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A Comprehensive PC-based Computer Model for Microdosimetry of BNCT

Verrijk

Huiskamp

Begg

et al. 1994

International Journal of Radiation Biology

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A computer model is described that performs microdosimetric calculations of the radiation dose delivered to tumour and normal tissue in boron neutron capture therapy (BNCT) by simulating capture reactions in a predefined three-dimensional space. The role of intracellular boron distributions and cellular dimensions on the radiation dose in clinical and experimental BNCT has been studied using a PC-based computer model. In order to calculate the radiation dose to low boron uptake cells, the extent of irradiation by boron containing adjacent cells (cross fire) is also dealt with. Radiation doses from boron and nitrogen neutron capture are converted to a biological effect by means of relative individual ion track segment efficacies, based on linear energy transfer along the particle track. A good correlation was found after comparing predicted values with previously published experimental data. A number of examples is given to illustrate the program's features.

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Cellular Pharmacokinetics of BNCT Compounds and their Cellular Localization with EELS/ESI

Cited by 2 publications

References 7 publications

The Development of Boron Analysis and Imaging in Boron Neutron Capture Therapy (BNCT)

The Development of Boron Analysis and Imaging in Boron Neutron Capture Therapy (BNCT)

A Comprehensive PC-based Computer Model for Microdosimetry of BNCT

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