Cellular pharmacokinetics and pharmacodynamics of dipyridamole in vascular smooth muscle cells

Anti-human immunodeficiency virus type 1 agent alpha-hydroxy glycineamide enters the target cells via a mechanism of passive diffusion

“…High temperature dependence with a high Q 10 value (>6) suggests a facilitated diffusion or active transport process. Moderate Q 10 between 2 and 6 cannot directly indicate the diffusion mechanism [27–29]. Uptake of αHGA exhibited low temperature dependency with a Q 10 value of less than two, which is a result indicating a mechanism of passive diffusion of αHGA across the cellular membrane.…”

“…To reveal a possible implication of transporters, the temperature dependency of αHGA uptake was studied. The mechanism of drug transport through the lipid bilayer of the cell membrane can be indicated by temperature coefficient (Q 10 ), which is defined as the factor by which the intracellular drug concentration increases as the temperature is raised by 10°C [27]…”

Expression of C-reactive protein in myointimal hyperplasia in a porcine arteriovenous graft model

“…Porcine venous SMCs were harvested from three pigs and cultured as described previously [14]. Briefly, a femoral vein segment (5 cm in length) was obtained from these animals.…”

Pharmacotherapy to improve outcomes in vascular access surgery: a review of current treatment strategies

“…Dipyridamole alone has been shown to inhibit VSMC proliferation induced by plateletderived growth factor (PDGF) and fibroblast growth factor [39,40]. Subsequent research, however, has demonstrated no effect of aspirin on VSMC proliferation and an inhibition using dipyridamole at concentrations in excess of physiological relevance if taken systemically [41], so the 'pleiotropic' effects of anti-platelets agents have yet to be fully established.…”