Cellular-membrane inspired surface modification of well aligned ZnO nanorods for chemosensing of epinephrine

Mohsin, Muhammad Ali; Liu, B. D.; Zhang, Xinglai; Yang, Wensheng; Liu, L. S.; Jiang, Xingyu

doi:10.1039/c6ra26250c

Cited by 8 publications

(4 citation statements)

References 55 publications

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“…Zinc oxide nanorod field-effect transistors (FETs) were monitored physiological conditions via the detection of glucose, cholesterol, and urea in the samples of mice’s blood, and diabetic dogs’ serum and blood [57]. Mohsin et al [189] reported using aligned ZnO nanorods for epinephrine sensing. Zinc oxide electrodes on flexible porous polyimide substrates were also developed for the detection of cardiac troponin [190].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Synthesis, Characterization, and Three-Dimensional Structure Generation of Zinc Oxide-Based Nanomedicine for Biomedical Applications

Jin

2019

Pharmaceutics

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Zinc oxide (ZnO) nanoparticles have been studied as metal-based drugs that may be used for biomedical applications due to the fact of their biocompatibility. Their physicochemical properties, which depend on synthesis techniques involving physical, chemical, biological, and microfluidic reactor methods affect biological activity in vitro and in vivo. Advanced tool-based physicochemical characterization is required to identify the biological and toxicological effects of ZnO nanoparticles. These nanoparticles have variable morphologies and can be molded into three-dimensional structures to enhance their performance. Zinc oxide nanoparticles have shown therapeutic activity against cancer, diabetes, microbial infection, and inflammation. They have also shown the potential to aid in wound healing and can be used for imaging tools and sensors. In this review, we discuss the synthesis techniques, physicochemical characteristics, evaluation tools, techniques used to generate three-dimensional structures, and the various biomedical applications of ZnO nanoparticles.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Synthesis, Characterization, and Three-Dimensional Structure Generation of Zinc Oxide-Based Nanomedicine for Biomedical Applications

Jin

2019

Pharmaceutics

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“…In the case of EP and NE, there are almost no existing detection systems, which is opposite to DA [ 72 , 73 ]. It is much more difficult to detect EP or NE because of their rapid metabolism and in fact, these molecules do not possess any fluorescence properties [ 74 ].…”

Section: Fluorescent Biosensors For Determination Of Neurotransmitmentioning

confidence: 99%

A Fluorescent Biosensors for Detection Vital Body Fluids’ Agents

Nawrot

Drzozga

Baluta

et al. 2018

Sensors

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The clinical applications of sensing tools (i.e., biosensors) for the monitoring of physiologically important analytes are very common. Nowadays, the biosensors are being increasingly used to detect physiologically important analytes in real biological samples (i.e., blood, plasma, urine, and saliva). This review focuses on biosensors that can be applied to continuous, time-resolved measurements with fluorescence. The material presents the fluorescent biosensors for the detection of neurotransmitters, hormones, and other human metabolites as glucose, lactate or uric acid. The construction of microfluidic devices based on fluorescence uses a variety of materials, fluorescent dyes, types of detectors, excitation sources, optical filters, and geometrical systems. Due to their small size, these devices can perform a full analysis. Microfluidics-based technologies have shown promising applications in several of the main laboratory techniques, including blood chemistries, immunoassays, nucleic-acid amplification tests. Of the all technologies that are used to manufacture microfluidic systems, the LTCC technique seems to be an interesting alternative. It allows easy integration of electronic and microfluidic components on a single ceramic substrate. Moreover, the LTCC material is biologically and chemically inert, and is resistant to high temperature and pressure. The combination of all these features makes the LTCC technology particularly useful for implementation of fluorescence-based detection in the ceramic microfluidic systems.

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“…In the case of epinephrine, there are just few existing detection systems, as opposed to dopamine or norepinephrine [12][13][14][15]. It is much more difficult to detect EP because of its rapid metabolism and due to the short epinephrine half-life in organisms [16]. Recently, an increase of interest in using the electrochemical biosensors and sensors in EP determination is observed [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Fluorescence Sensing Platforms for Epinephrine Detection Based on Low Temperature Cofired Ceramics

Baluta

Malecha

Świst

et al. 2020

Sensors

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A novel fluorescence-sensing pathway for epinephrine (EP) detection was investigated. The ceramic-based miniature biosensor was developed through the immobilization of an enzyme (laccase, tyrosinase) on a polymer—poly-(2,6-di([2,2′-bithiophen]-5-yl)-4-(5-hexylthiophen-2-yl)pyridine), based on low temperature cofired ceramics technology (LTCC). The detection procedure was based on the oxidation of the substrate, i.e., in the presence of the enzyme. An alternative enzyme-free system utilized the formation of a colorful complex between Fe2+ ions and epinephrine molecules. With the optimized conditions, the analytical performance illustrated high sensitivity and selectivity in a broad linear range with a detection limit of 0.14–2.10 nM. Moreover, the strategy was successfully used for an EP injection test with labeled pharmacological samples.

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Cellular-membrane inspired surface modification of well aligned ZnO nanorods for chemosensing of epinephrine

Abstract: Modified ZnO nanorods array to form a chemical sensor for neurotransmitters. The interspaces between the nanorods offer highly efficient immobilization of the lipid membrane containing the calixarene, which act as receptor molecule.

Cited by 8 publications

References 55 publications

Synthesis, Characterization, and Three-Dimensional Structure Generation of Zinc Oxide-Based Nanomedicine for Biomedical Applications

Synthesis, Characterization, and Three-Dimensional Structure Generation of Zinc Oxide-Based Nanomedicine for Biomedical Applications

A Fluorescent Biosensors for Detection Vital Body Fluids’ Agents

Fluorescence Sensing Platforms for Epinephrine Detection Based on Low Temperature Cofired Ceramics

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