Cellular mechanisms of duodenal ulcer healing. Is the quality of healing influenced by treatment?

Tarnawski, Andrzej S.; Tanoue, Kojiro; Santos, Anabela; Sarfeh, I. James

doi:10.1016/0016-5085(95)23607-4

Cited by 4 publications

(5 citation statements)

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“…Generally the antacids are eŠective in accelerating healing of duodenal and gastric ulcers, and the ulcer healing action by antacids is due to the neutralization of gastric luminal acid. 22) In present study, the ANC of CR extract and its constituents imply the increase of pH in gastric content in vitro. This result suggests that the CR extract may contribute for gastric protection, and the acidneutralizing activity works in a variety of conditions, such as the stomach upset, heartburn, the non-ulcer dyspepsia, and the veriˆed gastric and duodenal ulcers.…”

Section: Resultsmentioning

confidence: 51%

Anti-gastric Actions of Eugenol and Cinnamic Acid Isolated from Cinnamomi Ramulus

et al. 2011

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We investigated the evidence of gastric protection for ulcer and gastritis by Cinnamomi Ramulus (Cinnamomum cassia Blume, Geiji, CR) extract and its several constituents. CR ethanolic extract showed the potent antioxidant activity and cytotoxicity of Helicobacter pylori (H. pylori) and acid-neutralizing capacity. Especially, eugenol exerted a signiˆcant antioxidant activity and inhibited the colonization of H. pylori. In vivo test, eugenol and cinnamic acid signiˆcantly inhibited HCl/ethanol-induced gastric lesions and increased the mucus content though they didn't inhibit gastric secretion eŠectively. Taken together, eugenol and cinnamic acid, which were isolated from CR, exhibited the antioxidant activity in vitro and protective eŠect against gastric damage in vivo through stimulation of mucus secretion and so on. It suggested that they are useful as the neutraceuticals for gastritis.

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Section: Resultsmentioning

confidence: 51%

Anti-gastric Actions of Eugenol and Cinnamic Acid Isolated from Cinnamomi Ramulus

et al. 2011

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“…This is due to the effective Raman excitation and collection of the granulation tissue, reflecting the absence of the mucous membrane in benign ulcers. [39][40][41] Our further semi-quantitative non-negative least squares (NNLS) 25 fitting analysis of in vivo gastric Raman spectra using basis spectra of the six reference biochemicals (i.e., actin, collagen, DNA, histones, phosphatidylcholine and triolein) confirms the significantly larger contributions from collagen and actin in benign ulcers compared to normal mucosa (data not shown). The increase in Raman signals of actin (a major component of muscle cells) could be related to the Raman signal detected from the deeper muscularis mucosa layer together with the presence of actin-rich myofibroblasts within the granulation tissue.…”

Section: Discussionmentioning

confidence: 73%

“…It should be noted that the Raman endoscopic characterization of the bleeding ulcers and early malignancies primarily located in the ulcer margins warrants further investigations as the tissue properties could be markedly different from the ulcer bases (e.g., tissue architecture, blood flow, collagen distribution and tissue regenerative repair, etc.). 40,41,43 In summary, this work demonstrates for the first time that the image-guided Raman endoscopy technique developed can be used to reveal significant Raman spectral differences between normal mucosa, benign and malignant peptic ulcers in vivo during clinical gastroscopy. The Raman spectroscopic properties of gastric tissue can be effectively translated into a great wealth of diagnostic information providing new insights into biochemical and architectural changes of benign and malignant gastric ulcers in vivo.…”

Section: Discussionmentioning

confidence: 82%

Raman endoscopy for in vivo differentiation between benign and malignant ulcers in the stomach

Bergholt

Zheng

Lin

et al. 2010

Analyst

111

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The aim of this study was to evaluate the clinical utility of an image-guided Raman endoscopy technique for in vivo differential diagnosis of benign and malignant ulcerous lesions in the stomach. A rapid-acquisition image-guided Raman endoscopy system with 785 nm laser excitation has been developed to acquire in vivo gastric tissue Raman spectra within 0.5 s during clinical gastroscopic examinations. A total of 1102 in vivo Raman spectra were acquired from 71 gastric patients, in which 924 Raman spectra were from normal tissue, 111 Raman spectra were from benign ulcers whereas 67 Raman spectra were from ulcerated adenocarcinoma. There were distinctive spectral differences in Raman spectra among normal mucosa, benign ulcers and malignant ulcers, particularly in the spectral ranges of 800-900, 1000-1100, 1245-1335, 1440-1450 and 1500-1800 cm(-1), which primarily contain signals related to proteins, DNA, lipids and blood. The malignant ulcerous lesions showed Raman signals to be mainly associated with abnormal nuclear activity and decrease in lipids as compared to benign ulcers. Partial least squares-discriminant analysis (PLS-DA) was employed to generate multi-class diagnostic algorithms for classification of Raman spectra of different gastric tissue types. The PLS-DA algorithms together with leave-one tissue site-out, cross validation technique yielded diagnostic sensitivities of 90.8%, 84.7%, 82.1%, and specificities of 93.8%, 94.5%, 95.3%, respectively, for classification of normal mucosa, benign and malignant ulcerous lesions in the stomach. This work demonstrates that image-guided Raman endoscopy technique associated with PLS-DA diagnostic algorithms has for the first time promising clinical potential for rapid, in vivo diagnosis and detection of malignant ulcerous gastric lesions at the molecular level.

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“…A gastric ulcer refers to a mucosal defect in the stomach that extends to the submucosa or deeper layers. [1] It is mainly associated with Helicobacter pylori infection, as well as the use of nonsteroidal anti-inflammatory drugs (NSAIDs) or aspirin, which promote the development of gastric ulcers by disrupting the defense system of the gastric mucosa. [2,3] Recent reports suggest that NSAID-induced gastric ulcers are on the rise due to the increasing success of eradication programs targeting the decline in H. pylori infections, thus increasing the clinical importance of these ulcers.…”

Section: Introductionmentioning

confidence: 99%

“…A gastric ulcer refers to a mucosal defect in the stomach that extends to the submucosa or deeper layers [1] . It is mainly associated with Helicobacter pylori infection, as well as the use of nonsteroidal anti‐inflammatory drugs (NSAIDs) or aspirin, which promote the development of gastric ulcers by disrupting the defense system of the gastric mucosa [2,3] .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Acetic Acid‐Induced Chronic Gastric Ulcer Healing by Propionyl‐L‐Carnitine Administration

İpek

Aşıcı

Epikmen

et al. 2023

Chemistry & Biodiversity

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The aim of our study was to investigate the healing effect of propionyl‐L‐carnitine (PLC) on chronic gastric ulcers and its underlying mechanisms. This study included rats with gastric ulcers induced by applying serosal glacial acetic acid. These rats were then given either saline (vehicle) or PLC at doses of 60 and 120 mg/kg, administered orally 3 days after ulcer induction for 14 consecutive days. Our study found that treatment with PLC resulted in a reduction of the gastric ulcer area, a faster rate of ulcer healing, and stimulated mucosal restoration. Additionally, the treatment with PLC reduced the number of Iba‐1+ M1 macrophages while increasing the number of galectin‐3+ M2 macrophages, as well as desmin+ microvessels, and α‐SMA+ myofibroblasts in the gastric ulcer bed. The mRNA expression of COX‐2, eNOS, TGF‐β1, VEGFA, and EGF in the ulcerated gastric mucosa was greater in the PLC‐treated groups compared with the vehicle‐treated rats. In conclusion, these findings suggest that PLC treatment may accelerate gastric ulcer healing by stimulating mucosal reconstruction, macrophage polarization, angiogenesis, and fibroblast proliferation, as well as fibroblast‐myofibroblast transition. This process is associated with the upregulation of TGF‐β1, VEGFA, and EGF, as well as modulation of the cyclooxygenase/nitric oxide synthase systems.

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Cellular mechanisms of duodenal ulcer healing. Is the quality of healing influenced by treatment?

Cited by 4 publications

References 0 publications

Anti-gastric Actions of Eugenol and Cinnamic Acid Isolated from Cinnamomi Ramulus

Anti-gastric Actions of Eugenol and Cinnamic Acid Isolated from Cinnamomi Ramulus

Raman endoscopy for in vivo differentiation between benign and malignant ulcers in the stomach

Evaluation of Acetic Acid‐Induced Chronic Gastric Ulcer Healing by Propionyl‐L‐Carnitine Administration

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