Cellular Lipid Traffic and Lipid Transporters: Regulation of Efflux and HDL Formation

Marcel, Yves L.; Ouimet, Mireille; Wang, Mingdong

doi:10.1007/978-3-642-00300-4_3

Cited by 2 publications

(2 citation statements)

References 184 publications

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“…The components of LDs can also vary depending on cell type. For example, adipocyte LDs are TAG rich, while CEs are primarily abundant in macrophage LDs [ 27 ]. LD components are heterogeneous and vary according to cancer cell type and the tumor microenvironment.…”

Section: Lipid Droplets: Origin and Componentsmentioning

confidence: 99%

Lipid Droplets: A Key Cellular Organelle Associated with Cancer Cell Survival under Normoxia and Hypoxia

Koizume¹,

Miyagi²

2016

IJMS

159

136

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The Warburg effect describes the phenomenon by which cancer cells obtain energy from glycolysis even under normoxic (O2-sufficient) conditions. Tumor tissues are generally exposed to hypoxia owing to inefficient and aberrant vasculature. Cancer cells have multiple molecular mechanisms to adapt to such stress conditions by reprogramming the cellular metabolism. Hypoxia-inducible factors are major transcription factors induced in cancer cells in response to hypoxia that contribute to the metabolic changes. In addition, cancer cells within hypoxic tumor areas have reduced access to serum components such as nutrients and lipids. However, the effect of such serum factor deprivation on cancer cell biology in the context of tumor hypoxia is not fully understood. Cancer cells are lipid-rich under normoxia and hypoxia, leading to the increased generation of a cellular organelle, the lipid droplet (LD). In recent years, the LD-mediated stress response mechanisms of cancer cells have been revealed. This review focuses on the production and functions of LDs in various types of cancer cells in relation to the associated cellular environment factors including tissue oxygenation status and metabolic mechanisms. This information will contribute to the current understanding of how cancer cells adapt to diverse tumor environments to promote their survival.

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Section: Lipid Droplets: Origin and Componentsmentioning

confidence: 99%

Lipid Droplets: A Key Cellular Organelle Associated with Cancer Cell Survival under Normoxia and Hypoxia

Koizume¹,

Miyagi²

2016

IJMS

159

136

View full text Add to dashboard Cite

show abstract

“…Multiple components exist in LDs, and these components may vary among different types of cells. Triglyceride (TG) is the main component in LDs found in fatty cells, while cholesteryl ester is mainly located in macrophage LDs [ 99 ]. The concept of LDs has improved our understanding of the potential carcinogenesis in terms of cancer cell adaptability and resilience to microenvironmental stress [ 100 ].…”

Section: Lipid Dropletsmentioning

confidence: 99%

Lipid metabolism in tumor microenvironment: novel therapeutic targets

Liu

Zhang

et al. 2022

Cancer Cell Int

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Bioactive lipid molecules have been proposed to play important roles linking obesity/metabolic syndrome and cancers. Studies reveal that aberrant lipid metabolic signaling can reprogram cancer cells and non-cancer cells in the tumor microenvironment, contributing to cancer initiation, progression, metastasis, recurrence, and poor therapeutic response. Existing evidence indicates that controlling lipid metabolism can be a potential strategy for cancer prevention and therapy. By reviewing the current literature on the lipid metabolism in various cancers, we summarized major lipid molecules including fatty acids and cholesterol as well as lipid droplets and discussed their critical roles in cancer cells and non-cancer in terms of either promoting- or anti-tumorigenesis. This review provides an overview of the lipid molecules in cellular entities and their tumor microenvironment, adding to the existing knowledge with lipid metabolic reprogramming in immune cells and cancer associated cells. Comprehensive understanding of the regulatory role of lipid metabolism in cellular entities and their tumor microenvironment will provide a new direction for further studies, in a shift away from conventional cancer research. Exploring the lipid-related signaling targets that drive or block cancer development may lead to development of novel anti-cancer strategies distinct from traditional approaches for cancer prevention and treatment.

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Cellular Lipid Traffic and Lipid Transporters: Regulation of Efflux and HDL Formation

Cited by 2 publications

References 184 publications

Lipid Droplets: A Key Cellular Organelle Associated with Cancer Cell Survival under Normoxia and Hypoxia

Lipid Droplets: A Key Cellular Organelle Associated with Cancer Cell Survival under Normoxia and Hypoxia

Lipid metabolism in tumor microenvironment: novel therapeutic targets

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