Cellular Ligand–Receptor Perturbations Unravel MEIS2 as a Key Factor for the Aggressive Progression and Prognosis in Stage II/III Colorectal Cancer
Hui Xu,
Shuang Chen,
Jing Li
et al.
Abstract:Approximately 10−15% of stage II and 25−30% of stage III colorectal cancer (CRC) patients experience recurrence within 5 years after surgery, and existing taxonomies are insufficient to meet the needs of clinical precision treatment. Thus, robust biomarkers and precise management were urgently required to stratify stage II and III CRC and identify potential patients who will benefit from postoperative adjuvant therapy. Alongside, interactions of ligand−receptor pairs point to an emerging direction in tumor sig… Show more
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