Cellular life histories and bow tie biology

Lampl, Michelle

doi:10.1002/ajhb.20094

Cited by 25 publications

(24 citation statements)

References 94 publications

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“…While the present observations derive from a modest sample, the results describe an anatomical pattern that parallels a number of reports from animal models (Lampl, 2005). The specific sequence of organomegaly found in the present sample of smoke-exposed fetuses has been previously reported among hypoxemic mice, where renal hyperplasia preceded cardiomegaly: compared to HIF-deficient mice, normal animals exposed to chronic hypoxia up-regulated EPO and VEGF in kidney and heart within hours.…”

Section: Implications Of Facultative Fetal Growth Negotiated By Organsupporting

confidence: 86%

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Growth patterns of the heart and kidney suggest inter-organ collaboration in facultative fetal growth

Lampl

Kuzawa

Jeanty³

2005

Am. J. Hum. Biol.

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Maternal smoking during pregnancy has been associated with a number of negative sequelae among offspring, including elevated postnatal blood pressure. While animal studies have described organ level alterations with smoke exposure, human data have been more limited. Thirty-four healthy maternal/fetal pairs (24 nonsmokers, 10 smokers) participated in a longitudinal growth study from the thirteenth week of pregnancy to document fetal kidney and heart growth trajectories and morphology. Curve fitting followed by a mixed model for repeated measures identified significantly different growth patterns in kidney width, thickness, length, and volume growth with exposure: the smoke-exposed fetal kidney was wide and thick compared to the unexposed kidney during the second and early third trimester, declining to proportionately thin kidneys for length and width subsequently. Cardiac growth in width and volume followed a reverse pattern: a surge in cardiac volume occurred after 30 weeks with acceleration in cardiac width, resulting in a heart that was wide for length and for fetal weight. Smoke exposure altered fetal growth in size and timing of the heart and kidneys during midgestation, with changes in organ morphology suggesting compensatory growth. These are the first data providing anatomical evidence of altered renal/cardiac volume relationships that may provide a mechanism to previously reported sequelae of in utero smoke exposure. They suggest that cell-level adaptive responses to hypoxia and/or chemical insults are operative and illustrate the importance of longitudinal ultrasound to directly assess the organ-level growth response of the human fetus to a prenatal stress, in lieu of relying on birth outcome measures.

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Section: Implications Of Facultative Fetal Growth Negotiated By Organsupporting

confidence: 86%

“…proposed pathway preferences hypoxia signals as important to the growth cascade (Lampl, 2005). The details of such a process remain to be elucidated, but the present data allude to such a putative biology.…”

Section: Normal Versus Compensatory Growthmentioning

confidence: 93%

Growth patterns of the heart and kidney suggest inter-organ collaboration in facultative fetal growth

Lampl

Kuzawa

Jeanty³

2005

Am. J. Hum. Biol.

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“…This may be an expression of ''nested bow-tie'' metabolic architecture (Csete and Doyle, 2004;Lampl, 2005), in which cross-talking chemical pathways permit multiple avenues for information about the environment to have an impact on the amount and timing of growth events. With sufficient inhibitory feedback, a growth saltation will theoretically be suppressed.…”

Section: Growth Biology Is a Fundamental Interface Between The Speciementioning

confidence: 99%

Growth chart curves do not describe individual growth biology

Lampl

Thompson

2007

American J Hum Biol

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Growth reference tables present statistical distributions of size for age of individuals within a sample or population. As summaries of phenotypic variability at the group level, they document that individuals grow by different rates during similar time frames. The data are commonly fitted by mathematical functions to produce the convex curves of percentile distributions useful for infant and childhood growth monitoring. In this form, the growth chart appears to be a frame of reference for judging how well an individual infant/child is progressing through time by comparison with peers across ages. This has led to the assumption that individuals should track in these channels during growth. The interpolated lines between the statistical distributions of size for age at the level of the population do not, however, represent how individuals grow. Growing is an individual process characterized by nonlinear episodic saltatory increments that result in shifting size relationships among similarly aged peers over short time intervals. Data from a prospective, longitudinal study of infants illustrate the poor performance of growth chart curves as representations of individual growth. Clarification of the paradigms supporting perceptions of normal growth patterns is useful both practically and theoretically: growth chart patterns have important clinical sequelae when this informs feeding recommendations. Further characterization of individual growth patterns will contribute to increased understanding of both individual growth biology and the nature of adaptability.

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“…Conditions during intrauterine growth and development influence adult physiology (Crespi and Denver, 2005;Ellison, 2005;Horton, 2005;Jones, 2005;Kuzawa, 2005;Lampl, 2005;McDade, 2005;Pike, 2005;Worthman and Kuzara, 2005) and are related to the risk of major chronic diseases, including cardiovascular diseases and diabetes (Barker, 1995;Forsen et al, 1997) and also breast cancer in women. Several studies [but not all; see: Ekbom et al (1997), Sanderson et al (2002), andTitusErnstoff et al (2002)] have shown that the risk of breast cancer increases with increasing birth weight (Ahlgren et al, 2004;Andersson et al, 2001;De Stavola et al,et al, 2003;Michels, 1996), which is believed to be an indicator of conditions during fetal development.…”

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confidence: 99%

High ponderal index at birth predicts high estradiol levels in adult women

Jasieńska

Ziomkiewicz

Lipson

et al. 2005

American J Hum Biol

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Inter-individual variation in levels of sex hormones results from differences in genetic, developmental, and environmental factors. We tested a hypothesis that programming of the fetal neuroendocrine axis may predispose some women to produce higher levels of steroid hormones during their menstrual cycles as adults. One hundred forty-five regularly menstruating 24-to 36-year-old women collected daily saliva samples for one menstrual cycle. Data on women's birth weights and birth lengths were obtained from medical records. A positive relationship was observed between ponderal index at birth (an indicator of nutritional status, calculated as birth weight/(birth length) 3 ) and levels of estradiol (E2) in menstrual cycles, after controlling for potential confounding factors. Mean E2 was 16.4 pmol/l in the low ponderal index tertile, 17.3 pmol/l in the moderate ponderal index tertile, and 19.6 pmol/l in the high ponderal index tertile (the high ponderal index group had significantly higher E2 than both low and moderate ponderal index groups, P ¼ 0.0001). This study shows a positive association between ponderal index recorded for women at birth and levels of E2 measured during their menstrual cycles as adults. This suggests that conditions during fetal life influence adult production of reproductive hormones and may contribute to inter-individual variation in reproductive function. In addition, because large size at birth is one of the factors linked with an increased risk of breast cancer, our findings provide a physiological link for the observed positive relationship between indicators of energetic conditions during fetal growth and breast cancer in women. Am.

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Cellular life histories and bow tie biology

Cited by 25 publications

References 94 publications

Growth patterns of the heart and kidney suggest inter-organ collaboration in facultative fetal growth

Growth patterns of the heart and kidney suggest inter-organ collaboration in facultative fetal growth

Growth chart curves do not describe individual growth biology

High ponderal index at birth predicts high estradiol levels in adult women

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