Cellular interactions of covR/S mutant group A Streptococci

Langshaw, Emma; Pandey, Manisha; Good, Michael F.

doi:10.1016/j.micinf.2017.12.009

Cited by 5 publications

(5 citation statements)

References 27 publications

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“…Differential expression of GAS virulence factors is regulated by a multitude of transcriptional regulators, including the two‐component control of virulence regulatory system ( covRS ). In invasive GAS infections, spontaneous covRS mutations can cause an upregulation of several virulence factors, thereby promoting host‐adaptation and exacerbating disease (Langshaw, Pandey, & Good, 2018; Sumby, Whitney, Graviss, DeLeo, & Musser, 2006).…”

Section: Introductionmentioning

confidence: 99%

Inflammasome activation and IL ‐1β signalling in group A Streptococcus disease

Richter

Brouwer

Schroder

et al. 2021

Cellular Microbiology

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Group A Streptococcus (GAS) is a Gram‐positive bacterial pathogen that causes significant morbidity and mortality worldwide. Recent clinical evidence suggests that the inflammatory marker interleukin‐1β (IL‐1β) plays an important role in GAS disease progression, and presents a potential target for therapeutic intervention. Interaction with GAS activates the host inflammasome pathway to stimulate production and secretion of IL‐1β, but GAS can also stimulate IL‐1β production in an inflammasome‐independent manner. This review highlights progress that has been made in understanding the importance of host cell inflammasomes and IL‐1 signalling in GAS disease, and explores challenges and unsolved problems in this host‐pathogen interaction. Take Away Inflammasome signalling during GAS infection is an emerging field of research. GAS modulates the NLRP3 inflammasome pathway through multiple mechanisms. SpeB contributes to IL‐1β production independently of the inflammasome pathway. IL‐1β signalling can be host‐protective, but also drive severe GAS disease.

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Section: Introductionmentioning

confidence: 99%

Inflammasome activation and IL ‐1β signalling in group A Streptococcus disease

Richter

Brouwer

Schroder

et al. 2021

Cellular Microbiology

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“…CovR/S mutants, a hypervirulent update of group A streptococci (GAS), target neutrophils, as reported by Langshaw et al Consequently, the authors underscore the soundness of developing multi-component vaccines, targeting separate virulence mechanisms in parallel [18].…”

Section: Times Of Technologymentioning

confidence: 80%

Microbes and Infection turns 20

Häfner

Ojcius

2018

Microbes and Infection

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The journal Microbes and Infection is celebrating its vigintennial anniversary and has reunited for this occasion two dozen reviews illustrating achievements of the past as well as future challenges in the field of infectious diseases. From top-notch vaccine development strategies, to high-throughput powered analysis of complex host-pathogen interactions, to innovative therapeutic designs, this issue covers the entire spectrum of pathogens and areas of their confrontation with the host.

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“…Further studies showed that the expression of HA and M protein components of S. pyogenes capsular layers led to inflammasome activation, blockage of neutrophil extracellular trap (NET) formation, and macrophage pyroptosis (Wessels 2019;Chang and Nizet 2020). (Hynes and Sloan 2016;Frick et al 2018;Kurosawa et al 2018;Langshaw et al 2018;Estafanos 2019;Zhang 2020).…”

Section: Accepted Articlementioning

confidence: 99%