Cellular Interactions of a Water‐Soluble Supramolecular Polymer Complex of Carbon Nanotubes with Human Epithelial Colorectal Adenocarcinoma Cells

Lee, Yeon-Ju; Geckeler, Kurt E.

doi:10.1002/mabi.201200085

Cited by 18 publications

(6 citation statements)

References 45 publications

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“…For the delivery of paclitaxel in Caco-2 cells single-walled carbon nanotubes conjugated with a synthetic polyampholyte were used. Paclitaxel-SWCNTtreated Caco-2 and HT-29 cells showed greater anticancer effects when compared with alone paclitaxel (Lee and Geckeler, 2012;Wu et al, 2015). The same types of results have been found in Eudragit ® -irinotecan loaded CNTs (Zhou et al, 2014).…”

Section: Carbon Nanotubessupporting

confidence: 71%

Nanotechnology in Colorectal Cancer for Precision Diagnosis and Therapy

Brar

Ranjan

Palria

et al. 2021

Front. Nanotechnol.

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Colorectal cancer (CRC) is the third most frequently occurring tumor in the human population. CRCs are usually adenocarcinomatous and originate as a polyp on the inner wall of the colon or rectum which may become malignant in the due course of time. Although the therapeutic options of CRC are limited, the early diagnosis of CRC may play an important role in preventive and therapeutic interventions to decrease the mortality rate. The CRC-affected tissues exhibit several molecular markers that may be exploited as the novel strategy to develop newer approaches for the treatment of the disease. Nanotechnology consists of a wide array of innovative and astonishing nanomaterials with both diagnostics and therapeutic potential. Several nanomaterials and nano formulations such as Carbon nanotubes, Dendrimer, Liposomes, Silica Nanoparticles, Gold nanoparticles, Metal-organic frameworks, Core-shell polymeric nano-formulations, Nano-emulsion System, etc can be used to targeted anticancer drug delivery and diagnostic purposes in CRC. The light-sensitive photosensitizer drugs loaded gold and silica nanoparticles can be used to diagnose as well as the killing of CRC cells by the targeted delivery of anticancer drugs to cancer cells. This review is focused on the recent advancement of nanotechnology in the diagnosis and treatment of CRC.

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Section: Carbon Nanotubessupporting

confidence: 71%

Nanotechnology in Colorectal Cancer for Precision Diagnosis and Therapy

Brar

Ranjan

Palria

et al. 2021

Front. Nanotechnol.

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“…Several antitumour-drug-carriers-strategies based on CNTs have been developed. In one of them, the single-walled carbon nanotubes (SWCNTs) conjugated with a synthetic polyampholyte for the delivery of paclitaxel demonstrated greater anticancer effects in Caco-2 and HT-29 cells compared to paclitaxel alone [3,155]. A similar effect was observed using Eudragit ® -irinotecan-loaded CNTs [3,156].…”

Section: Carbon-based Nanomaterialsmentioning

confidence: 87%

Promising Therapeutic Strategies for Colorectal Cancer Treatment Based on Nanomaterials

Krasteva

Georgieva

2022

Pharmaceutics

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Colorectal cancer (CRC) is a global health problem responsible for 10% of all cancer incidences and 9.4% of all cancer deaths worldwide. The number of new cases increases per annum, whereas the lack of effective therapies highlights the need for novel therapeutic approaches. Conventional treatment methods, such as surgery, chemotherapy and radiotherapy, are widely applied in oncology practice. Their therapeutic success is little, and therefore, the search for novel technologies is ongoing. Many efforts have focused recently on the development of safe and efficient cancer nanomedicines. Nanoparticles are among them. They are uniquewith their properties on a nanoscale and hold the potential to exploit intrinsic metabolic differences between cancer and healthy cells. This feature allows them to induce high levels of toxicity in cancer cells with little damage to the surrounding healthy tissues. Graphene oxide is a promising 2D material found to play an important role in cancer treatments through several strategies: direct killing and chemosensitization, drug and gene delivery, and phototherapy. Several new treatment approaches based on nanoparticles, particularly graphene oxide, are currently under research in clinical trials, and some have already been approved. Here, we provide an update on the recent advances in nanomaterials-based CRC-targeted therapy, with special attention to graphene oxide nanomaterials. We summarise the epidemiology, carcinogenesis, stages of the CRCs, and current nanomaterials-based therapeutic approaches for its treatment.

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“…52 Among antimicrotubules, paclitaxel (PTX) and docetaxel (DTX) have been widely studied. [53][54][55][56][57][58][59][60][61][62][63] Arya et al 53 reported that SWCNTs increase PTX activity against lung cancer by reactive-oxygen-species-dependent synergy between CNTs and PTX. They confirmed the efficacy on A549 and NCI-H460 cell lines.…”

Section: Cnts As Antimicrotubule Carriersmentioning

confidence: 99%

Carbon nanotubes as cancer therapeutic carriers and mediators

Son¹,

Hong²,

Lee³

2016

IJN

218

106

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Carbon nanotubes (CNTs) have received increasing attention in biomedical fields because of their unique structures and properties, including high aspect ratios, large surface areas, rich surface chemical functionalities, and size stability on the nanoscale. Particularly, they are attractive as carriers and mediators for cancer therapy. Through appropriate functionalization, CNTs have been used as nanocarriers for anticancer drugs including doxorubicin, camptothecin, carboplatin, cisplatin, paclitaxel, Pt(II), and Pt(IV), and genes including plasmid DNA, small-interfering RNA, oligonucleotides, and RNA/DNA aptamers. CNTs can also deliver proteins and immunotherapy components. Using combinations of light energy, they have also been applied as mediators for photothermal therapy and photodynamic therapy to directly destroy cancer cells without severely damaging normal tissue. If limitations such as a long-term cytotoxicity in the body, lack of size uniformity during the synthetic process, loading deviations for drug–CNT complexes, and release controllability at the target point are overcome, CNTs will become one of the strongest tools that are available for various other biomedical fields as well as for cancer therapy.

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Cellular Interactions of a Water‐Soluble Supramolecular Polymer Complex of Carbon Nanotubes with Human Epithelial Colorectal Adenocarcinoma Cells

Cited by 18 publications

References 45 publications

Nanotechnology in Colorectal Cancer for Precision Diagnosis and Therapy

Nanotechnology in Colorectal Cancer for Precision Diagnosis and Therapy

Promising Therapeutic Strategies for Colorectal Cancer Treatment Based on Nanomaterials

Carbon nanotubes as cancer therapeutic carriers and mediators

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