Cellular interaction and retrotransposition of porcine endogenous retrovirus

Retroviral Insertion Polymorphism (RIP) of Porcine Endogenous Retroviruses (PERVs) in Pig Genomes

“…Porcine endogenous retroviruses (PERVs) show different copy numbers in different organs, indicating that they are active [5][6][7][8]. Moreover, ERVs do not lose their retrotransposition ability; this was also shown for other ERV [9], in a study that showed a frequency of retrotransposition of up to 1.2 × 10 −6 for PERV and 5 × 10 −7 for MoMLV per cell per generation in single experiments, indicating that a PERV retrotransposition happens more than twice as often as a MoMLV retrotransposition. Our previous findings indicate that ERV6A and ERV6B, which possess the gag, pol, and env domains, represent the most recently classified family with potential transposable activity [10].…”

Xenotransplantation literature update May–August, 2007

“…Another international symposium on xenotransplantation was held in Berlin, Germany, in June 2007. There were contributions by Reichart [18], Vallabhapurapu et al [19], Cooper [20], Kra¨mer [21], Hering [22], Ulrichs [23], Cozzi et al [24], Schuurman [25], Petersen et al [26], Plege et al [27], Kessler et al [28], Burdorf et al [29], Jungmann et al [30], Siepert et al [31], and Dieckhoff et al [32] on present status and knowledge of various fields related to xenotransplantation, from stem cells to risk assessment related to xenozoonosis.…”