1991
DOI: 10.1016/0145-305x(91)90010-v
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Cellular immune response of a marsupial, Monodelphis domestica

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Cited by 25 publications
(7 citation statements)
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“…The lymphocyte proliferation test mitogen stimulation gives a reflection of the cell mediated immune response associated with the activation of T lymphocytes. The proliferation of lymphocytes at day 300 post‐partum was similar to that previously reported for healthy adult male and female possums of 144,321 and 230,588 DPM respectively (Infante et al, 1991; Stone et al, 1998; Baker et al, 1998). However, at the time of weaning at day 150–200 post‐partum, the proliferative response of lymphocytes was still considerably lower than that of the adult.…”
Section: Discussionsupporting
confidence: 87%
“…The lymphocyte proliferation test mitogen stimulation gives a reflection of the cell mediated immune response associated with the activation of T lymphocytes. The proliferation of lymphocytes at day 300 post‐partum was similar to that previously reported for healthy adult male and female possums of 144,321 and 230,588 DPM respectively (Infante et al, 1991; Stone et al, 1998; Baker et al, 1998). However, at the time of weaning at day 150–200 post‐partum, the proliferative response of lymphocytes was still considerably lower than that of the adult.…”
Section: Discussionsupporting
confidence: 87%
“…In contrast to the great attention being paid to the MHC of eutherian mammals, birds and fish, the diverse group of marsupials has been poorly investigated so far. Earlier studies on marsupial cellular immunology reported dramatic differences in the immune response between marsupials and eutherians and predicted little or no polymorphism at the MHC class II genes [ 19 - 21 ]. Only recently has the complete MHC region been mapped for the first marsupial ( Monodelphis domestica ) [ 22 , 23 ].…”
Section: Introductionmentioning
confidence: 99%
“…Marsupials have a weak or even non-existent mixed lymphocyte response yet mount a normal graft rejection response [27]. Initially, it was thought that this weak MLR was the result of a low level of MHC Class II variability [28], an amino acid substitution in the MHC molecule [27] or even a difference in the ontogeny of marsupial and eutherian T cells [29]. The absence of immunomodulation by LST1 may also be a contributing a factor.…”
Section: Discussionmentioning
confidence: 99%