Cellular immune response in intraventricular experimental neurocysticercosis

Moura, Vânia Beatriz Lopes; Lima, Sarah Buzaim; Matos-Silva, Hidelberto; Vinaud, Marina Clare; Loyola, Patricia R. A. N.; Lino, Ruy S.

doi:10.1017/s0031182015001572

Cited by 23 publications

(18 citation statements)

References 62 publications

(101 reference statements)

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“…All the control animals showed discrete levels of edema and hyperemia due to the mechanical trauma of the inoculation of sterile saline solution. These discrete alterations in the control group have also been observed in other experimental NCC studies 6,13,18,21 . In the infected animals, the majority of the cysticerci were located inside the lateral ventricles accompanied by a discrete-to-moderate intensity of inflammatory response.…”

Section: Discussionsupporting

confidence: 82%

“…Matos-Silva et al 6 also found similar results using the T. crassiceps NCC model. Using the same model, Moura et al 18 described a predominance of the Th2 immune profile cytokines at the end of the infection, while in the acute phase of the infection there was a mixed Th1/Th17 profile accompanied by high levels of IL-10.…”

Section: Discussionmentioning

confidence: 99%

“…It has also already been described that T. crassiceps cysticerci are able to induce NCC in immunocompromised 16 and immunocompetent individuals 17 . In this model, the infected animals presented with tissue alterations and lesions such as encephalitis, perivasculitis, ventriculomegaly, ependymitis, meningitis, microgliosis accompanied by the parasite's death, and extraparenchymal and parenchymal inflammatory infiltration 6,18 . Other experimental models have been proposed but instead of using T. crassiceps cysticerci they performed an intracranial inoculation of T. solium oncospheres in rats 19 and in swine 20 .…”

mentioning

confidence: 99%

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Experimental neurocysticercosis: absence of IL-4 induces lower encephalitis

Silva

Vinaud

Júnior

2017

Arq. Neuro-Psiquiatr.

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Neurocysticercosis (NCC) is the most severe clinical manifestation of cysticercosis. One of the factors responsible for its symptomatology is the host inflammatory response. Therefore the influence of interleukin 4 (IL-4) on the induction of encephalitis in experimental NCC was evaluated. Methods BALB/c (WT) and BALB/c (IL-4-KO) mice were inoculated intracranially with Taenia crassiceps cysticerci and euthanized at 7, 30, 60 and 90 days later, the encephala removed and histopathologically analyzed. Results The absence of IL-4 induced greater parasitism. In the initial phase of the infection, IL-4-KO showed a lower intensity in the inflammatory infiltration of polimorphonuclear cells in the host-parasite interface and intra-parenquimatous edema. The IL-4-KO animals, in the late phase of the infection, showed lower intensity of ventriculomegaly, encephalitis, and meningitis, and greater survival of the parasites in comparison with the WT animals. Conclusion The absence of IL-4 induced lower inflammatory infiltration, ventriculomegaly and perivasculitis in experimental NCC.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Experimental neurocysticercosis: absence of IL-4 induces lower encephalitis

Silva

Vinaud

Júnior

2017

Arq. Neuro-Psiquiatr.

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“…They are directly injected in the peritoneal or intracranial cavity, which is not their natural route of infection. Moura et al., (2015) used the same model to study the cellular immune response. They noticed mixed Th1/Th17 responses at acute phase of infection and a predominantly Th2 response at late stage.…”

Section: Animal Models For Neurocysticercosismentioning

confidence: 99%

Recent advancements and new perspectives in animal models for Neurocysticercosis immunopathogenesis

Arora

Tripathi

Kumar

et al. 2017

Parasite Immunology

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Neurocysticercosis (NCC), one of the most common parasitic diseases of the central nervous system, is caused by Taenia solium. This parasite involves two hosts, intermediate hosts (pig and human) and a definitive host (human) and has various stages in its complex life cycle (eggs, oncosphere, cysticerci and adult tapeworm). Hence, developing an animal model for T. solium that mimics its natural course of infection is quite challenging. We have reviewed here the animal models frequently used to study immunopathogenesis of cysticercosis and also discussed their usefulness for NCC studies. We found that researchers have used mice, rats, guinea pigs, dogs, cats and pigs as models for this disease with varying degrees of success. Mice and rats models have been utilized extensively for immunopathogenesis studies due to their relative ease of handling and abundance of commercially available reagents to study these small animal models. These models have provided some very exciting results for in-depth understanding of the disease. Of late, the experimentally/naturally infected swine model is turning out to be the best animal model as the disease progression closely resembles human infection in pigs. However, handling large experimental animals has its own challenges and limitations.

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“…The immune response in mice infected with T. crassiceps is not well described in NCC models. However, Moura et al 15 , studying an intraventricular experimental NCC model, reported that BALB/c mice presented with a predominance of a systemic mixed Th1/Th17 immune profile in the initial phases of the infection, while this gradually modified into a Th2 profile through the course of the infection.…”

mentioning

confidence: 99%

Histopathologic aspects of experimental cysticercosis and in situ cytokines profile in C57BL/6 mice

Milhomem

Souza

Silva³

et al. 2018

Arq. Neuro-Psiquiatr.

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Neurocysticercosis (NCC) is one of the parasitic infections that most affects the central nervous system. The knowledge regarding its immunopathogenesis and pathophysiology needs broadening. Taenia crassiceps cysticerci are used as the NCC experimental model. The aim of this work was to describe the general pathological processes and the in situ cytokine profile in C57BL/6 mice inoculated intracranially with viable T. crassiceps cysticerci. The histopathology analysis showed cysticerci in the extraparenchymal and intraventricular region, mononuclear inflammatory infiltration surrounding the parasite, microgliosis and meningitis. The analysis of the in situ immune profiles showed a predominance of the Th2 response. The IL-4 and IL-10 dosages were significantly increased in the infected group. The decrease in the INF-gamma dosage reflects the immunomodulation from the cysticerci. In conclusion, a T. crassiceps NCC infection in C57BL/6 mice triggers an inflammatory response, a predominance of Th2 type in situ profile, with mononuclear inflammatory cell infiltration, meningitis and microgliosis.

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Cellular immune response in intraventricular experimental neurocysticercosis

Cited by 23 publications

References 62 publications

Experimental neurocysticercosis: absence of IL-4 induces lower encephalitis

Experimental neurocysticercosis: absence of IL-4 induces lower encephalitis

Recent advancements and new perspectives in animal models for Neurocysticercosis immunopathogenesis

Histopathologic aspects of experimental cysticercosis and in situ cytokines profile in C57BL/6 mice

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