Cellular Immune Competence of Breast Cancer Patients Receiving Radiotherapy

Cosimi, A. Benedict; Brunstetter, Frank H.; Kemmerer, William T.; Miller, Beverly N.

doi:10.1001/archsurg.1973.01350220015005

Cited by 66 publications

(10 citation statements)

References 14 publications

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“…Although methods have varied and results differed, most workers agree that RT causes a decrease in the response to mitogens (5,(34)(35)(36)(37)(38). A few have found that RT does not effect the lymphocyte response to mitogens (37,39,40).…”

Section: Resultsmentioning

confidence: 99%

A comparison of the acute effects of radiation therapy, including or excluding the thymus, on the lymphocyte subpopulations of cancer patients.

Stratton¹,

Byfield²,

Byfield³

et al. 1975

J. Clin. Invest.

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A B S T R A C T Radiation therapy to either mediastinum or pelvis causes a rapid decrease in circulating lymphocytes of both B and T types and in addition an impairment in the function of the remaining lymphocytes, as measured by their ability to proliferate in response to mitogens. The acute depression is short-lived. Substantial recovery is apparent within 3 wk after cessation of therapy; however, most patients show a modest, chronic depression in both numbers and functional capacities of circulating lymphocytes. T cells are somewhat more sensitive than B cells, but both are affected.Irradiation of the thymus per se seems to have little influence on the acute changes which occur, as patients receiving pelvic and mediastinal (including thymic) radiotherapy show a similar degree of lymphopenia and depression of lymphocyte responsiveness.

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Section: Resultsmentioning

confidence: 99%

A comparison of the acute effects of radiation therapy, including or excluding the thymus, on the lymphocyte subpopulations of cancer patients.

Stratton¹,

Byfield²,

Byfield³

et al. 1975

J. Clin. Invest.

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“…However, at the completion of treatment, the mean total lymphocyte count of 503/mm3 was 4 SD below the mean for normal controls. Acute lymphocytopenia after a course of radiation has been described in a variety of clinical situations involving localized or extended field radiotherapy (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Recovery usually begins shortly after completion of treatment (6,7,12), and continues through the next 1-2 yr.…”

Section: Introductionmentioning

confidence: 99%

Long term effects of radiation of T and B lymphocytes in peripheral blood of patients with Hodgkin's disease.

Fuks¹,

Strober²,

Bobrove³

et al. 1976

J. Clin. Invest.

268

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“…Tumors are known to induce immune suppression; over a decade ago, CD4+ T-cell anergy was reported as a common early event in tumor progression [17]. Immune suppression after radiation [18] and chemotherapy [19] has long been documented in cancer patients. These findings help explain tumor progression in spite of the presence of tumor-specific T-cell populations.…”

Section: Monitoring Immune Competencementioning

confidence: 99%

Monitoring the immune competence of cancer patients to predict outcome

Chang

Kohrt

Maecker

2014

Cancer Immunol Immunother

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A new era of cancer immunotherapy has brought not only successful cancer vaccines but also immunomodulators, such as those that target checkpoint blockade in order to induce endogenous host immune responses. However, the immune system of cancer patients can be compromised through multiple means, including immune suppression by the tumor and by prior therapies such as chemotherapy and radiation. Therefore, a comprehensive means of assessing patient immunocompetence would seem helpful for determining whether patients are ready to benefit from immunotherapy, and perhaps even which immunotherapy might be most appropriate for them. Unfortunately, there are no standardized tests for immune competence, nor is there agreement on what to measure and what will be predictive of outcome. In this review, we will discuss the technologies and assays that might be most useful for this purpose. We argue for a comprehensive approach that should maximize the chances of developing predictive biomarkers for eventual clinical use.

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Cellular Immune Competence of Breast Cancer Patients Receiving Radiotherapy

Cited by 66 publications

References 14 publications

A comparison of the acute effects of radiation therapy, including or excluding the thymus, on the lymphocyte subpopulations of cancer patients.

A comparison of the acute effects of radiation therapy, including or excluding the thymus, on the lymphocyte subpopulations of cancer patients.

Long term effects of radiation of T and B lymphocytes in peripheral blood of patients with Hodgkin's disease.

Monitoring the immune competence of cancer patients to predict outcome

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