Cellular Hypersensitivity In Subacute Sclerosing Panencephalitis

Mizutani, Hiromichi

doi:10.1001/jama.1971.03180330075025

Cited by 23 publications

(5 citation statements)

References 6 publications

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“…Although both infection and vaccination with the live measles virus may result in long-term immunity and antibody formation, 17,18 immunological degenerations have been reported in some SSPE patients. 19 Mizutani et al 20 demonstrated the presence of cellular immunity against the measles antigen by using a skin test and a macrophage migration inhibition test in a 9-year old girl with SSPE. Moulias et al 21 demonstrated the absence of a cellular response against the measles antigen in a serial study that involved 20 SSPE cases using a leucocyte migration and blastic transformation test.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Lymphocyte Subgroups in Children with Subacute Sclerosing Panencephalitis

et al. 2009

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The aetiology of subacute sclerosing panencephalitis (SSPE) remains to be fully elucidated, although it follows infection with a hypermutant defective M-protein measles virus. This study analysed peripheral blood lymphocyte subgroups to determine their role in the pathophysiology of SSPE. It included 22 children with SSPE aged 2 - 15 years (patient group) and 22 age- and gender-matched healthy children (control group). In children < 6 years old, there were no statistically significant differences between the two groups in the proportions of lymphocytes expressing the surface markers CD3, CD8, CD19 or CD16/56, or in CD4/CD8 ratio. The proportion of CD4(+) lymphocytes in SSPE patients < 6 years of age was significantly lower compared with the control group. In children >or= 6 years old, there were no significant differences in the lymphocyte subgroups. In conclusion, these findings suggest that a low CD4(+) lymphocyte count might be responsible for SSPE in younger children.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Lymphocyte Subgroups in Children with Subacute Sclerosing Panencephalitis

et al. 2009

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“…Saunders et al (12) studied the in vitro response of an 8~i-year old boy with SSPE to measles antigen and found specific immunocompetent lymphocytes in the patient and postulated that the destructive interaction between such lymphocytes and host cells in the brain may lead to SSPE. Mizutani et al (13) confirmed the presence of cellular immunity to measles antigen in a 9-year old girl with SSPE, using skin testing and macrophage migration inhibition as an index. On the other hand, Moulias et al (14) tested 20 cases of SSPE and found that none of them responded to measles antigen as judged by blastic transformation and leukocyte migration tests.…”

mentioning

confidence: 93%

“…X 100.fluid was cross-reactive in its effect on cells from either SSPE patient or measles sero-positive controls° Lymphocyte Transformation Test:--Purified peripheral blood lymphocytes from R. S. (SSPE patient) showed a significant response to SSPE virus-infected HeLa cells(Tables V and VI). R. S. lymphocytes cultured with noninfected HeLa cells gave 354(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) cpm. When cultured with SSPE virus infected cells, they produced 4,656 (4-1197) cpm, which gives a stimulation index of 13.9.…”

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confidence: 99%

Demonstration of a Blocking Factor in the Plasma and Spinal Fluid of Patients With Subacute Sclerosing Panencephalitis

Ahmed

Strong

Sell

et al. 1974

The Journal of Experimental Medicine

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Conflicting reports on the immune responsiveness of patients with subacute sclerosing panencephalitis (SSPE) have been reported. This report shows that the leucocytes from four SSPE patients exhibited strong sensitivity to both measles and SSPE virus preparations as measured by the macrophage migration inhibition test, mixed lymphocyte virus infected cell culture test, and the lymphotoxin assay. Earlier suggestions that a factor may be operating to suppress cellular reactivity are confirmed by the demonstration that the response of lymphocytes from SSPE patients could be blocked by the addition of SSPE spinal fluid or plasma. It was determined that the blocking factor was stable at –20°C, heat labile at 56°C for 30 minutes, trypsin and neuraminadase sensitive, and had a mol wt greater than 150,000 as determined by Sephadex G-200 gel chromatography. The blocking factor appeared to be specific for SSPE virus and did not block the response of lymphocytes to nonspecific mitogenic agents and other viral and bacterial agents.

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“…Reports of immunocompetence in patients with subacute sclerosing panencephalitis, a chronic demyelinating encephalitis associated with an MV-like agent, are conflicting. Some studies indicate that subacute sclerosing panencephalitis is accompanied by subtle.immunological abnormalities (14,17,26,28).. Other reports find no relationship (2,27,33).…”

mentioning

confidence: 99%

Effects of canine distemper virus infection on lymphoid function in vitro and in vivo

Krakowka¹,

Cockerell²,

Koestner³

1975

Infect Immun

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In the present study, the immunodepressive effects of canine distemper virus (CDV) infection of dogs on two parameters of lymphocyte function, namely phytomitogen-induced cellular proliferation and skin allograft rejection, were investigated. Infection of susceptible gnotobiotic dogs with virulent R252-CDV resulted in a depression of peripheral blood lymphocyte mitogen response as measured by (3H)thymidine incorporation for up to 10 weeks after inoculation. This effect coincided with the appearance of viral antigen by immunofluorescence in leukocytes but persisted after the virus was no longer detectable. Loss of mitogen reactivity was seen in all infected dogs. However, when these same CDV-infected dogs were challenged with foreign skin allografts, no significant retention of grafts over controls was observed despite the depressed lymphocyte activity. Considering the in vitro and in vivo data it was concluded that, although immunodepressive effects of CDV were demonstrated in vitro, paralled in vivo experiments indicated that less than complete suppression of immune functions occurs during the course of CDV infection.

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Cellular Hypersensitivity In Subacute Sclerosing Panencephalitis

Cited by 23 publications

References 6 publications

Evaluation of Lymphocyte Subgroups in Children with Subacute Sclerosing Panencephalitis

Evaluation of Lymphocyte Subgroups in Children with Subacute Sclerosing Panencephalitis

Demonstration of a Blocking Factor in the Plasma and Spinal Fluid of Patients With Subacute Sclerosing Panencephalitis

Effects of canine distemper virus infection on lymphoid function in vitro and in vivo

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