Cellular Growth Factors and Exosomes

Topical growth factor preparations for facial skin rejuvenation: A systematic review

“…Challenges exist with performing controlled studies with cosmeceutical preparations included in this review. First, vehicle or placebo controls are generally not inactive and often demonstrate benefits by virtue of skin hydration and reduced epidermal water loss 6 . These effects can result in difficulty in demonstrating statistical significance even in controlled, double‐blind studies.…”

“…Most natural sources of growth factors also secrete exosomes, membrane‐bound extracellular vesicles, as part of their secreted cell materials. Exosomes are present in all conditioned media‐based products and carry a large variety of signaling molecules responsible for skin repair and regeneration 6,73 . It is likely that exosomes contribute significantly to the efficacy of all conditioned media‐based products.…”

“…Growth factors have emerged as novel anti‐aging agents due to their recognized role in dermal wound repair 4,5 . Growth factors are regulatory proteins that mediate signaling pathways between and within cells 6 . In the skin, they are found naturally in fibroblasts and are responsible for the synthesis of collagen and the extracellular matrix 7 .…”

“…Similarities in the biochemical pathways involved in the aging process and wound healing have resulted in the development of topical products employing growth factor technology 5 . Aging and wound healing both stimulate the release of growth factors, which affect a variety of biochemical pathways critical to repair the dermal matrix 6 . Multiple clinical studies over the last 20 years show that topical application of preparations containing growth factors can stimulate collagen synthesis and thereby decrease the appearance of fine lines and wrinkles 7 …”

“…4,5 Growth factors are regulatory proteins that mediate signaling pathways between and within cells. 6 In the skin, they are found naturally in fibroblasts and are responsible for the synthesis of collagen and the extracellular matrix. 7 Similarities in the biochemical pathways involved in the aging process and wound healing have resulted in the development of topical products employing growth factor technology.…”