Current Opinion in Hematology volume 20, issue 5, P403-409 2013 DOI: 10.1097/moh.0b013e3283634412 View full text
Susan A. Maroney, Karen G. Hansen, Alan E. Mast

Abstract: AbstractPurpose of review-Tissue factor pathway inhibitor (TFPI) is an anticoagulant protein that inhibits tissue factor-factor VIIa (TF-fVIIa) and factor Xa (fXa). Recent studies revealed distinct cellular expression patterns for TFPI and TFPI and spurred additional experiments to define unique functions for these alternatively spliced TFPI isoforms.Recent findings-TFPI is produced by endothelial cells, localizes to an intracellular granule, and is released following cellular stimulation with thrombin or hep…

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