Cellular dynamics in pig-to-human kidney xenotransplantation

Pan, Wanqing; Zhang, Weimin; Zheng, Binghan; Camellato, Brendan R.; Stern, Jeffrey; Lin, Ziyan; Khodadadi-Jamayran, Alireza; Kim, Jacqueline; Sommer, Philip; Khalil, Karen; Weldon, Elaina; Bai, Jiangshan; Zhu, Yinan; Meyn, Peter; Heguy, Adriana; Mangiola, Massimo; Griesemer, Adam; Keating, Brendan J.; Montgomery, Robert A.; Xia, Bo; Boeke, Jef D.

doi:10.1016/j.medj.2024.05.003

Med

2024

DOI: 10.1016/j.medj.2024.05.003

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Cellular dynamics in pig-to-human kidney xenotransplantation

Wanqing Pan,

Weimin Zhang,

Binghan Zheng

et al.

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2024

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Cited by 2 publications

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Opportunities and challenges for immunosuppression in the context of pig-to-human xenotransplantation

Onyeaghala,

Dorr,

Israni

2024

Med

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Opportunities and challenges for immunosuppression in the context of pig-to-human xenotransplantation

Onyeaghala,

Dorr,

Israni

2024

Med

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In Vivo Luciferin–Luciferase Reaction in Micro-Mini Pigs Using Xenogeneic Rat Bone Marrow Transplantation

Abe,

Endo,

Hanazono

et al. 2024

IJMS

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Luminescent technology based on the luciferin–luciferase reaction has been extensively employed across various disciplines as a quantitative imaging modality. Owing to its non-invasive imaging capacity, it has evolved as a valuable in vivo bioimaging tool, particularly in small animal models in fields such as gene and cell therapies. We have previously successfully generated rats with a systemic expression of the luciferase gene at the Rosa26 locus. In this study, we transplanted bone marrow from these rats into micro-mini pigs and used in vivo imaging to non-invasively analyze the dynamics of the transplanted cells. In addition, we established that the rat-to-pig transplantation system is a discordant system, similar to the pig-to-human transplantation system. Thus, rat-to-pig transplantation may provide a clinically appropriate large animal model for pig-to-human xenotransplantation.

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Cellular dynamics in pig-to-human kidney xenotransplantation

Cited by 2 publications

References 55 publications

Opportunities and challenges for immunosuppression in the context of pig-to-human xenotransplantation

Opportunities and challenges for immunosuppression in the context of pig-to-human xenotransplantation

In Vivo Luciferin–Luciferase Reaction in Micro-Mini Pigs Using Xenogeneic Rat Bone Marrow Transplantation

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