Cellular distribution of the rat D4 dopamine receptor protein in the CNS using anti-receptor antisera

Antidepressant-Like Effect of D2/3 Receptor-, but not D4 Receptor-Activation in the Rat Forced Swim Test

“…Similar to D 3 receptors, D 4 receptors have been extensively investigated as a target for the treatment of schizophrenia. Interestingly, distribution of D 4 receptors in brain areas associated with regulation of emotions and cognition such as prefrontal cortex and mesolimbic areas (Matsumoto et al, 1995;Ariano et al, 1997;Tarazi et al, 1997;Oak et al, 2000) also make them an intriguing candidate to play a role in depressive-like behaviors. However, using selective (Moreland et al, 2004), and the lack of efficacy blocking the effect of quinpirole in FST suggest that D 4 receptors are clearly not involved in the mediation of antidepressant-like activity.…”

Regulation of Working Memory by Dopamine D4 Receptor in Rats

“…There is evidence that the same neurons are modulated by D 4 receptor. Notably, several immunocytochemical studies indicate that D 4 receptor resides in pyramidal neurons in PFC (Ariano et al, 1997;Mrzljak et al, 1996;Wedzony et al, 2000). The presence of D 4 receptor in pyramidal neurons places this receptor in an ideal location to modulate working memory.…”

Role of Dopamine D4 Receptors in Motor Hyperactivity Induced by Neonatal 6-Hydroxydopamine Lesions in Rats

“…ablation results in hyperactivity in response to environmental stimuli in primates (Fuster 1989;Wilkinson et al 1997), as well as supersensitive behavioral responses to both external and internal stimuli in rats (Bubser and Schmidt 1990;Flores et al 1996;Lacroix et al 1998). Relatively high levels of D 4 receptors are expressed in glutamatergic pyramidal neurons and GABAergic interneurons in PFC, as well as in the nerve terminals of glutamatergic projections from PFC to CPu (Ariano et al 1997;Mrzljak et al 1996;Tarazi et al 1998a;De la Garza and Madras 2000), suggesting that the excitatory output from PFC to subcortical structures may be inhibited by D 4 receptors. We did not find altered D 4 receptor binding in PFC or NAc of 6-OHDA-lesioned rats (Table 1).…”