Cellular distribution of the calcium-binding proteins parvalbumin, calbindin, and calretinin in the neocortex of mammals: phylogenetic and developmental patterns

Hof, Patrick R.; Glezer, Ilya I.; Condé, Françoise; Flagg, Roxana A.; Rubin, Marina; Nimchinsky, Esther A.; Weisenhorn, Daniela M. Vogt

doi:10.1016/s0891-0618(98)00065-9

Cited by 387 publications

(383 citation statements)

References 172 publications

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“…Sin embargo, al evaluar la presencia de células positivas para PV en el asta dorsal del ratón, se observó marcación en las láminas I y II, lo que no concuerda con los reportes previos en ratas y otros mamíferos, ya que se ha descrito su presencia sólo en la margen inferior de la lámina II y, por lo general, no se reporta su inmunorreacción en la lámina I (8,(20)(21)(22)(23)(24). Estas diferencias específicas para las especies en la distribución de proteínas como la PV, se han reportado anteriormente en otras áreas del sistema nervioso de los mamíferos (25). Por otra parte, al estudiar el área ventromedial y el asta ventral de la médula espinal, la marcación de CB y PV no muestra diferencias con los reportes anteriores en gato (8) y rata (20).…”

Section: Distribución De Cb Y Pv En La Médula Espinal De Ratonesunclassified

Distribución de calbindina y parvoalbúmina y efecto del virus de la rabia sobre su expresión en la médula espinal de ratones

Monroy-Gómez

Torres‐Fernández

2013

biomedica

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Contribución de los autores:Jeison Monroy-Gómez: planeación y diseño del trabajo; desarrollo de los experimentos, análisis de resultados, elaboración de borrador del manuscrito y revisión final. Orlando Torres-Fernández: idea, planeación, diseño y dirección general del trabajo; análisis de resultados, revisión y versión final del manuscrito. ARTÍCULO ORIGINAL Biomédica 2013;33:564-73 doi: http://dx.doi.org/10.7705/biomedica.v33i4.1552 Distribución de calbindina y parvoalbúmina y efecto del virus de la rabia sobre su expresión en la médula espinal de ratones Introducción. Aunque se trata de una enfermedad infecciosa del sistema nervioso, poco se conoce sobre los mecanismos patogénicos de la infección con el virus de la rabia. En particular, son escasos los estudios sobre su histopatología en la médula espinal. Objetivo. Estudiar la distribución de las proteínas calbindina y parvoalbúmina, en la médula espinal de ratones y evaluar el efecto de la infección con el virus de la rabia sobre su expresión. Materiales y métodos. Se inocularon ratones con virus de la rabia, por vía intracerebral o intramuscular, y se extrajo la médula espinal para hacer cortes transversales, los cuales se sometieron a tratamiento inmunohistoquímico con anticuerpos monoclonales para revelar la presencia de las dos proteínas en ratones normales y en animales infectados. Se llevó a cabo el análisis cualitativo y cuantitativo de la inmunorreacción de las dos proteínas. Resultados. Las proteínas calbindina y parvoalbúmina se distribuyeron de manera diferencial en las láminas de Rexed. La infección con el virus de la rabia produjo una disminución en la expresión de calbindina. Por el contrario, la infección provocó un incremento en la expresión de parvoalbúmina. El efecto de la rabia sobre las dos proteínas fue similar al comparar las dos vías de inoculación. Conclusión. El efecto diferencial de la infección con el virus de la rabia sobre calbindina y parvoalbúmina en la médula espinal de ratones, es similar al reportado anteriormente para áreas encefálicas. Esto sugiere uniformidad en su respuesta a la infección en todo el sistema nervioso central y es un aporte importante para el conocimiento de la patogénesis de la rabia.Palabras clave: virus de la rabia, médula espinal, neuronas, ratones, inmunohistoquímica. doi: http://dx.doi.org/10.7705/biomedica.v33i4.1552 Calbindin and parvalbumin distribution in spinal cord of normal and rabies-infected miceIntroduction: Rabies is a fatal infectious disease of the nervous system; however, the knowledge about the pathogenic neural mechanisms in rabies is scarce. In addition, there are few studies of rabies pathology of the spinal cord. Objective: To study the distribution of calcium binding proteins calbindin and parvalbumin and assessing the effect of rabies virus infection on their expression in the spinal cord of mice. Materiales y methods: Mice were inoculated with rabies virus, by intracerebral or intramuscular route. The spinal cord was extracted to perform some crosscuts which were treated ...

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Section: Distribución De Cb Y Pv En La Médula Espinal De Ratonesunclassified

Distribución de calbindina y parvoalbúmina y efecto del virus de la rabia sobre su expresión en la médula espinal de ratones

Monroy-Gómez

Torres‐Fernández

2013

biomedica

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“…Given these affinities it is worth noting that there are similarities in cortical cytoarchitecture and neurochemistry between cetaceans and ungulates (Hof et al, 1999). It would be interesting to compare how these similarities (and differences) have been expressed at gross neuroanatomical levels in cetaceans and various ungulates.…”

Section: Evolutionary Considerationsmentioning

confidence: 99%

“…It would be interesting to compare how these similarities (and differences) have been expressed at gross neuroanatomical levels in cetaceans and various ungulates. For instance, Hof et al (1999) have noted the early physical maturity of the brain in both cetaceans and ungulates and the possibility that both brains may be characterized by a number of pedomorphic features.…”

Section: Evolutionary Considerationsmentioning

confidence: 99%

Anatomy and three‐dimensional reconstructions of the brain of a bottlenose dolphin (Tursiops truncatus) from magnetic resonance images

et al. 2001

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Cetacean (dolphin, whale, and porpoise) brains are among the least studied mammalian brains because of the formidability of collecting and histologically preparing such relatively rare and large specimens. Magnetic resonance imaging offers a means of observing the internal structure of the brain when traditional histological procedures are not practical. Furthermore, internal structures can be analyzed in their precise anatomic positions, which is difficult to accomplish after the spatial distortions often accompanying histological processing. In this study, images of the brain of an adult bottlenose dolphin, Tursiops truncatus, were scanned in the coronal plane at 148 antero-posterior levels. From these scans a computer-generated three-dimensional model was constructed using the programs VoxelView and VoxelMath (Vital Images, Inc.). This model, wherein details of internal and external morphology are represented in three-dimensional space, was then resectioned in orthogonal planes to produce corresponding series of virtual sections in the horizontal and sagittal planes. Sections in all three planes display the sizes and positions of major neuroanatomical features such as the arrangement of cortical lobes and subcortical structures such as the inferior and superior colliculi, and demonstrate the utility of MRI for neuroanatomical investigations of dolphin brains. Anat Rec 264: [397][398][399][400][401][402][403][404][405][406][407][408][409][410][411][412][413][414] 2001.

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“…smooth nonpyramidal neurons), which display different chemical characteristics for a variety of neurotransmitters, cell surface markers, and receptors. 51,52 In contrast, ␤-parvalbumin is only expressed in preterm placenta. 50 The latter data at least partly explain why calbindin-D 28k , calretinin, ␣-parvalbumin, and ␤-parvalbumin may be differently expressed in medulloblastomas.…”

Section: Discussionmentioning

confidence: 99%

Calbindin‐D_28k

Pelc¹,

Vincent

Ruchoux

et al. 2002

Cancer

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BACKGROUNDThe expression of the Ca2+‐binding protein calbindin‐D28k was analyzed in medulloblastomas in relation to clinical features and other biologic markers related to cell proliferation, differentiation, p53, and cerebellar developmental regulated gene expression.METHODSImmunohistochemistry was carried out on histologic slides from a first retrospective series of 29 nonmetastatic and 10 metastatic medulloblastoma formalin‐fixed, paraffin‐embedded tissues, using specific antibodies against calbindin‐D28k, calretinin, α‐parvalbumin and β‐parvalbumin, and S100 proteins. Informed consent was obtained from the subjects and/or guardians. Other biologic markers for differentiation, cell proliferation, the expression of the p53 tumor suppressor gene protein, and cerebellar developmental regulated genes were similarly investigated. A second series of 16 medulloblastomas from young patients (younger than 15 years) was added in order to validate the results obtained in the first series.RESULTSOf all the markers investigated, only calbindin‐D28k was significantly associated with prognosis. Survival and remission (i.e. recurrence free) time analysis performed on all the cases (n = 55) confirmed a high risk of death (P = 0.004) and recurrence (P = 0.003) associated with calbindin‐positivity. As calbindin‐positivity was predominantly observed in tumors from young patients, the authors confirmed its prognostic value in the subgroup of patients younger than 15 years (n = 37). Cox regression analysis showed a significant and independent prognostic value for calbindin expression and, to a lesser extent, the type of surgery (total or subtotal). Three risk groups were thus identified, distinguishing among the cases characterized by a total resection and calbindin‐negativity (good prognosis), by a subtotal resection and calbindin‐negativity (intermediary), and by calbindin‐positivity (bad prognosis).CONCLUSIONSThe current study suggests that calbindin‐positive medulloblastomas represent a subclass of aggressive tumors more frequently seen in younger patients. Cancer 2002;95:410–9. © 2002 American Cancer Society.DOI 10.1002/cncr.10666

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Cellular distribution of the calcium-binding proteins parvalbumin, calbindin, and calretinin in the neocortex of mammals: phylogenetic and developmental patterns

Cited by 387 publications

References 172 publications

Distribución de calbindina y parvoalbúmina y efecto del virus de la rabia sobre su expresión en la médula espinal de ratones

Distribución de calbindina y parvoalbúmina y efecto del virus de la rabia sobre su expresión en la médula espinal de ratones

Anatomy and three‐dimensional reconstructions of the brain of a bottlenose dolphin (Tursiops truncatus) from magnetic resonance images

Calbindin‐D_28k

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Cellular distribution of the calcium-binding proteins parvalbumin, calbindin, and calretinin in the neocortex of mammals: phylogenetic and developmental patterns

Cited by 387 publications

References 172 publications

Distribución de calbindina y parvoalbúmina y efecto del virus de la rabia sobre su expresión en la médula espinal de ratones

Distribución de calbindina y parvoalbúmina y efecto del virus de la rabia sobre su expresión en la médula espinal de ratones

Anatomy and three‐dimensional reconstructions of the brain of a bottlenose dolphin (Tursiops truncatus) from magnetic resonance images

Calbindin‐D28k

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Calbindin‐D_28k