Cellular distribution of isozymes of protein kinase C in septal olfactory epithelium of mice

Kang, Wha Sun; Lee, Woon Kyu; Seo, Min-Seok; Kim, Jong Kee; Han, Ji Won; Moon, Young-Hyun; Cho, Kyung-Keun; Kim, Myung Joon; Lee, Kweon-Haeng; Kim, Yong Sik; Jo, Yang-Hyeok; Choi, Chang Rak

doi:10.1016/s0304-3940(00)01230-1

Cited by 3 publications

(1 citation statement)

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“…PLC β2 cells do possess an axon-like basal process, but it needs to be determined, whether this process in fact represents a functional axon that could transmit action potentials. Protein kinase C (PKC) β1 (Kang et al, 2000), ecto-5'-nucleotidase (Braun & Zimmermann, 1998; Alexandra Veyrac and Francois Jourdan, personal communication), and Ca 2+ -binding proteins (Yamagishi et al, 1993) have also been detected on microvillous olfactory cells with a similar density and morphology. PKC β and many Ca 2+ -binding proteins are involved in regulating InsP 3 -mediated signalling processes (Kasri et al, 2004;Mikoshiba, 1997).…”

Section: "Jourdan Cells'': a Lifeboat For Insp 3 In Olfaction?mentioning

confidence: 99%

Morituri te salutant? Olfactory signal transduction and the role of phosphoinositides

Elsaesser

Paysan

2005

J Neurocytol

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During the past 150 years, researchers have investigated the cellular, physiological, and molecular mechanisms underlying the sense of smell. Based on these efforts, a conclusive model of olfactory signal transduction in the vertebrate's nose is now available, spanning from G-protein-mediated odorant receptors to ion channels, which are linked by a cyclic adenosine 3',5'-monophosphate-mediated signal transduction cascade. Here we review some historical milestones in the chronology of olfactory research, particularly emphasising the role of cyclic nucleotides and inositol trisphosphate as alternative second messengers in olfactory cells. We will describe the functional anatomy of the nose, outline the cellular composition of the olfactory epithelium, and describe the discovery of the molecular backbone of the olfactory signal transduction cascade. We then summarize our current model, in which cyclic adenosine monophosphate is the sole excitatory second messenger in olfactory sensory neurons. Finally, a possible significance of microvillous olfactory epithelial cells and inositol trisphosphate in olfaction will be discussed.

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