Cellular colocalization of diuretic peptides in locusts: A potent control mechanism

Thompson, Kevin; Rayne, Richard C.; Gibbon, Charles R.; May, Sean; Patel, Manju; Coast, Geoffrey M.; Bacon, Jonathan P.

doi:10.1016/0196-9781(94)00158-3

Cited by 62 publications

(43 citation statements)

References 21 publications

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“…In all of the other species studied, including R. prolixus, strong CRF-like immunoreactivity has been observed in a subset of the medial NSCs of the brain (Te Brugge et al, 1999;Cabrero et al, 2002;Iaboni et al, 1998;Patel et al, 1994;Veenstra and Hagedorn, 1991;Emery et al, 1994). As well, the immunoreactivity observed in the posterior lateral NSCs in the abdominal neuromeres of the MTGM of R. prolixus is consistent with the immunoreactivity observed in abdominal ganglia of L. migratoria (Patel et al, 1994;Thompson et al, 1995) and M. sexta (Chen et al, 1994).…”

Section: Distribution Of the Rhopr Dhsupporting

confidence: 68%

“…CRF-like immunoreactivity and expression in posterior lateral NSCs in the MTGM of R. prolixus is consistent with the immunoreactivity and expression pattern found in other insects (Patel et al, 1994;Thompson et al, 1995;Chen et al, 1994;Roller et al, 2008). In B. mori, DH 41 and DH 34 CRF-like expression was observed in dorsolateral cells of the abdominal ganglia (2-7), which are thought to be the lateral NSCs, L3.…”

Section: Distribution Of the Rhopr Dhsupporting

confidence: 65%

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Identification of the elusive peptidergic diuretic hormone in the blood-feeding bugRhodnius prolixus: a CRF-related peptide

Brugge

Paluzzi

Schooley

et al. 2011

Journal of Experimental Biology

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SUMMARYProbing of a host and ingestion of a blood-meal in a fifth instar Rhodnius prolixus results in a cascade of tightly integrated events. The huge blood-meal is pumped into the anterior midgut during feeding, then modified by diuresis and stored until it is digested. While serotonin is known to be a diuretic hormone in R. prolixus, a peptidergic factor(s) was also known to play a role in diuresis. In the present study we employed molecular techniques and mass spectrometry to determine the sequence of a native CRF-like peptide from R. prolixus (Rhopr DH). In addition, we confirmed the distribution and localization of Rhopr DH using in situ hybridization and immunohistochemistry, and demonstrated its potent biological activity on both the anterior midgut and Malpighian tubules.

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Section: Distribution Of the Rhopr Dhsupporting

confidence: 68%

Section: Distribution Of the Rhopr Dhsupporting

confidence: 65%

Identification of the elusive peptidergic diuretic hormone in the blood-feeding bugRhodnius prolixus: a CRF-related peptide

Brugge

Paluzzi

Schooley

et al. 2011

Journal of Experimental Biology

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“…Curious that agents which stimulate hindgut contractions might also enhance excretory activity in Malpighian tubules upstream, we discovered that leucokinin has diuretic effects in Malpighian tubules of the yellow fever mosquito Aedes aegypti (Hayes et al, 1989). Since then, the stimulation of fluid secretion by leucokinin and other kinins has been found in Malpighian tubules of the house cricket (Coast et al, 1990), locust (Thompson et al, 1995), tobacco hornworm (Blackburn et al, 1995), fruit fly (O'Donnell et al, 1996) and housefly (Iaboni et al, 1998). In Malpighian tubules of the yellow fever mosquito, locust and cricket, leucokinin is thought to increase transepithelial secretion of Cl -, thereby increasing the transepithelial secretion of Na + , K + and water (Coast, 2001;Pannabecker et al, 1993).…”

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confidence: 97%

Effects of leucokinin-VIII onAedesMalpighian tubule segments lacking stellate cells

Beyenbach

2004

Journal of Experimental Biology

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“…Tubule function is modulated by an ensemble of different peptide and amine transmitters (Coast, 1996). Among the peptide hormones that increase fluid secretion at the tubule are leucokinin, corticotropin releasing factor (CRF)-like diuretic hormones, calcitonin-like diuretic hormones and the CAP2B-related peptides (Johnson, 2006); some of these hormones are coexpressed in the same cells (Chen et al, 1994;Thompson et al, 1995). The leucokinin peptide targets the stellate cells of the Malpighian tubule and increases a calciumactivated chloride conductance (Terhaz et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Functional differences between two CRF-related diuretic hormone receptors in Drosophila

Hector

Bretz

Zhao

et al. 2009

Journal of Experimental Biology

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SUMMARYIn Drosophila, two related G-protein-coupled receptors are members of the corticotropin releasing factor (CRF) receptor subfamily. We have previously reported that one of these receptors, encoded by CG8422 is a functional receptor for a diuretic hormone, DH 44 . Here, we report that the other CRF receptor subfamily member, encoded by CG12370, is also a receptor for the DH 44 neuropeptide. The lines of evidence to support this identification include increases in cAMP levels due to CG12370 receptor activation and the recruitment of β-arrestin-GFP to the plasma membrane in response to DH 44 application. We compared these features of the receptors DH44-R2 (encoded by CG12370) and DH44-R1 (encoded by CG8422) and found fundamental differences in signaling, association with the arrestins, and peptide sensitivity. We found that the sensitivity of DH44-R2 to the DH 44 peptide is lower than that of DH44-R1, specifically an estimated EC 50 of 7.98E-07 mol l -1 for DH 44 by DH44-R2 to an EC 50 of 5.12E-09 mol l -1 by DH44-R1 and found that previous reports on the sensitivity of the tubule to DH 44 is in agreement with our measurements of DH44-R2 sensitivity. We employed a specific RNAi construct to selectively knock-down DH44-R2 expression and this led to heightened sensitivity to osmotic challenges. The functional characterization of this diuretic hormone receptor in Drosophila demonstrates a high degree of conservation of CRF-like signaling.

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Cellular colocalization of diuretic peptides in locusts: A potent control mechanism

Cited by 62 publications

References 21 publications

Identification of the elusive peptidergic diuretic hormone in the blood-feeding bugRhodnius prolixus: a CRF-related peptide

Identification of the elusive peptidergic diuretic hormone in the blood-feeding bugRhodnius prolixus: a CRF-related peptide

Effects of leucokinin-VIII onAedesMalpighian tubule segments lacking stellate cells

Functional differences between two CRF-related diuretic hormone receptors in Drosophila

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