Cellular co-localization of phosphorylated tau- and NACP/α-synuclein-epitopes in Lewy bodies in sporadic Parkinson's disease and in dementia with Lewy bodies

Microtubule-associated Protein 1B Is a Component of Cortical Lewy Bodies and Binds α-Synuclein Filaments

“…MAP-1B and tau (8). The later prediction is supported by the demonstration of tau proteins in some Lewy bodies (32).…”

Immunotherapeutic Approaches Targeting Amyloid-β, α-Synuclein, and Tau for the Treatment of Neurodegenerative Disorders

“…Furthermore, as these proteins may co-aggregate and/or regulate each other [29,30,[159][160][161], immunization against one of them could reduce the aggregation or toxic modification of the others. For example, immunization against Aβ might be helpful at reducing α-syn and tau if administered at early disease stages [62]; likewise, α-syn antibodies might also be helpful in AD [162], and immunization against tau might be useful for PD [161,163]. In this sense, identifying and targeting polyvalent antigens or using single-chain polyvalent antibodies targeting simultaneously Aβ, tau, and α-syn could have synergistic effects, as it occurs with polyvalent vaccines for certain cancers and infections [164,165].…”

GSK-3β : une kinase au cœur des maladies neuro-dégénératives ?

“…Ainsi, des inclusions d' -synucléine de type corps de Lewy ont été trouvées dans le cerveau de patients atteints de MA. Inversement, des agrégats de protéine Tau sont fréquemment détectés à la périphérie des corps de Lewy présents dans des cerveaux atteints de MP ou de démence à corps de Lewy [26]. Dans le cerveau de patients atteints d'une forme génétique de MP due à une mutation de l' -synucléine [42], des agrégats composés de Tau et de synucléine ont été trouvés [27].…”