Cellular bioterrorism: how Brucella corrupts macrophage physiology to promote invasion and proliferation

Maria-Pilar, Jimenez de Bagues; Dudal, Sherri; Dornand, Jacques; Gross, Antoine

doi:10.1016/j.clim.2004.07.010

Cited by 64 publications

(27 citation statements)

References 90 publications

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“…In fact, ROS and nitric oxide production have been shown to be important for microbicidal activity against Brucella in macrophages (126). SodC, a Cu/Zn superoxide dismutase that counteracts ROS production, is required by B. abortus for survival within macrophages and virulence in a mouse model of infection (127).…”

Section: Brucellamentioning

confidence: 99%

Contrasting Lifestyles Within the Host Cell

Case

Samuel

2016

Microbiol Spectr

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CHAPTER SUMMARY Intracellular bacterial pathogens have evolved to exploit the protected niche provided within the boundaries of a eukaryotic host cell. Upon entering a host cell, some bacteria can evade the adaptive immune response of its host, and replicate in a relatively nutrient-rich environment devoid of competition from other host flora. Growth within a host cell is not without its hazards, however. Many pathogens enter their hosts through receptor-mediated endocytosis or phagocytosis, two intracellular trafficking pathways that terminate in a highly degradative organelle, the phagolysosome. This usually deadly compartment is maintained at a low pH, and contains degradative enzymes, and reactive oxygen species resulting in an environment to which few bacterial species are adapted. Some intracellular pathogens, like Shigella, Listeria, Francisella, and Rickettsia escape the phagosome to replicate within the cytosol of the host cell. Bacteria that remain within a vacuole either alter the trafficking of their initial phagosomal compartment or adapt to survive within the harsh environment it will soon become. In this chapter, we focus on the mechanisms by which different vacuolar pathogens either evade lysosomal fusion, as in the case of Mycobacterium and Chlamydia, or allow interaction with lysosomes to varying degrees, such as Brucella and Coxiella, and their specific adaptations to inhabit a replicative niche.

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Section: Brucellamentioning

confidence: 99%

Contrasting Lifestyles Within the Host Cell

Case

Samuel

2016

Microbiol Spectr

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“…As pathogens evolve they acquire the necessary virulence factors to invade and propagate within their hosts. Brucella has virulence factors that are important in the hostepathogen interaction and modifying phagocytosis, phagolysosome fusion, cytokine secretion and apoptosis [2]. Once intracellular, Brucella localizes in early phagosomes avoiding fusion with late endosomes and lysosomes [3].…”

Section: Introductionmentioning

confidence: 99%

The role of the vacB gene in the pathogenesis of Brucella abortus

Miyoshi

Rosinha

Camargo

et al. 2007

Microbes and Infection

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“…After entering the host, Brucella is taken up by macrophage and dendritic cells. Brucella can survive and replicate in this immune cells and evad adaptive immune system (21,23). Macrophages are key elements in the cellular immune response against intracellular bacteria like Brucella (17).…”

Section: 12cell-mediated Immunitymentioning

confidence: 99%

Vaccines and Vaccine Candidates against Brucellosis

Mansoori¹,

Pourmand²

2016

IEM

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Brucella is a facultative intracellular pathogen, and brucellosis is commonest zoonotic disease worldwide. Brucella species, isolated from domestic animals, are important pathogen for humans. Annually, more than 500,000 new cases of brucellosis are reported, and this figure is an underestimate due to extended under-reporting cases in several endemic countries. Brucella has a variety of virulence mechanisms that prevent detection and activation of innate immunity, but protection against intracellular pathogen is represented by cell-mediated immunity. As yet, much research has been performed to develop a safe Brucella vaccine to control the disease in human and animals. Despite the availability of several live attenuated vaccine for animals, currently, no effective human vaccine is available. Moreover, due to the potential use of Brucella in bioterrorism or biowarfare, development of an effective vaccine against brucellosis for human use is necessary. In this paper, we aimed to review and discuss the efforts of researchers to develop vaccines against Brucellosis.

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Cellular bioterrorism: how Brucella corrupts macrophage physiology to promote invasion and proliferation

Cited by 64 publications

References 90 publications

Contrasting Lifestyles Within the Host Cell

Contrasting Lifestyles Within the Host Cell

The role of the vacB gene in the pathogenesis of Brucella abortus

Vaccines and Vaccine Candidates against Brucellosis

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