Cellular basis and developmental timing in a size cline of Drosophila melanogaster.

James, Andrew; Azevedo, Ricardo B. R.; Partridge, Linda

doi:10.1093/genetics/140.2.659

Cited by 249 publications

(34 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overall these results suggest that there are no major functional differences associated with these naturally occurring foxo alleles with respect to development time. This is somewhat congruent with data on Australian clines, where the relationship between body size and development time is inconsistent across latitudes (e.g., James et al, 1995, 1997). Development time was the most variable of the traits studied here, both with respect to experimental replication and variation among natural as well as reconstituted outbred populations.…”

Section: Resultssupporting

confidence: 88%

“…As expected, these results are consistent with previous associations between latitude and body size in D . melanogaster (e.g., Coyne & Beecham, 1987; James et al, 1995; de Jong & Bochdanovits, 2003).…”

Section: Resultsmentioning

confidence: 99%

“…These traits vary with latitude in D . melanogaster (Coyne & Beecham, 1987; James et al, 1995; Schmidt et al, 2005); thus, the foxo gene is a logical candidate for determining variation for these traits in natural populations (de Jong & Bochdonavits, 2003). However, while it is clear that foxo laboratory mutants or transgenes have highly pleiotropic effects on life‐history phenotypes, polymorphisms segregating in natural populations need not necessarily affect variance for traits related to gene function (e.g., Stern, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Body size is a trait commonly associated with fitness in a variety of taxa (Blanckenhorn, 2000; Bonnet et al, 2017; Brown et al, 1993) including Drosophila melanogaster (e.g., Promislow et al, 1998; Reeve et al, 2001; reviewed in Flatt, 2020). Size often varies predictably across environmental gradients such as those associated with latitude (Ashton, 2002; Blanckenhorn & Demont, 2004; Huey et al, 2000; James et al, 1995; Stillwell et al, 2007); such clines suggest that body size is affected by spatially varying selection and reflects local adaptation (Partridge & Coyne, 1997; Stillwell, 2010). While size‐related traits are in general highly polygenic (e.g., Boyle et al, 2017), individual loci can have large effects on size (e.g., Sutter et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…In Drosophila melanogaster , body size increases with increasing latitude on multiple continents (Coyne & Beecham, 1987; James et al, 1995, 1997; Karan et al, 1998). Such latitudinal patterns are mirrored by altitudinal clines where size increases with increasing altitude (Fabian et al, 2015; Lack et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Allelic polymorphism at foxo contributes to local adaptation in Drosophila melanogaster

et al. 2021

View full text Add to dashboard Cite

The insulin/insulin‐like growth factor signalling pathway has been hypothesized as a major determinant of life‐history profiles that vary adaptively in natural populations. In Drosophila melanogaster, multiple components of this pathway vary predictably with latitude; this includes foxo, a conserved gene that regulates insulin signalling and has pleiotropic effects on a variety of fitness‐associated traits. We hypothesized that allelic variation at foxo contributes to genetic variance for size‐related traits that vary adaptively with latitude. We first examined patterns of variation among natural populations along a latitudinal transect in the eastern United States and show that thorax length, wing area, wing loading, and starvation tolerance exhibit significant latitudinal clines for both males and females but that development time does not vary predictably with latitude. We then generated recombinant outbred populations and show that naturally occurring allelic variation at foxo, which exhibits stronger clinality than expected, is associated with the same traits that vary with latitude in the natural populations. Our results suggest that allelic variation at foxo contributes to adaptive patterns of life‐history variation in natural populations of this genetic model.

show abstract

Section: Resultssupporting

confidence: 88%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Allelic polymorphism at foxo contributes to local adaptation in Drosophila melanogaster

et al. 2021

View full text Add to dashboard Cite

show abstract

Life history evolution and cellular mechanisms associated with increased size in high‐altitude Drosophila

Lack

Yassin

Sprengelmeyer

et al. 2016

Ecology and Evolution

View full text Add to dashboard Cite

Understanding the physiological and genetic basis of growth and body size variation has wide‐ranging implications, from cancer and metabolic disease to the genetics of complex traits. We examined the evolution of body and wing size in high‐altitude Drosophila melanogaster from Ethiopia, flies with larger size than any previously known population. Specifically, we sought to identify life history characteristics and cellular mechanisms that may have facilitated size evolution. We found that the large‐bodied Ethiopian flies laid significantly fewer but larger eggs relative to lowland, smaller‐bodied Zambian flies. The highland flies were found to achieve larger size in a similar developmental period, potentially aided by a reproductive strategy favoring greater provisioning of fewer offspring. At the cellular level, cell proliferation was a strong contributor to wing size evolution, but both thorax and wing size increases involved important changes in cell size. Nuclear size measurements were consistent with elevated somatic ploidy as an important mechanism of body size evolution. We discuss the significance of these results for the genetic basis of evolutionary changes in body and wing size in Ethiopian D. melanogaster.

show abstract

Thermal plasticity in postembryonic life history traits of a widely distributed Collembola: Effects of macroclimate and microhabitat on genotypic differences

Sengupta

Ergon

Leinaas

2017

Ecology and Evolution

View full text Add to dashboard Cite

Life history traits in many ectotherms show complex patterns of variation among conspecific populations sampled along wide latitudinal or climatic gradients. However, few studies have assessed whether these patterns can be explained better by thermal reaction norms of multiple life history traits, covering major aspects of the life cycle. In this study, we compared five populations of a Holarctic, numerically dominant soil microarthropod species, Folsomia quadrioculata, sampled from a wide latitudinal gradient (56–81°N), for growth, development, fecundity, and survival across four temperatures (10, 15, 20, and 25°C) in common garden experiments. We evaluated the extent to which macroclimate could explain differences in thermal adaptation and life history strategies among populations. The common garden experiments revealed large genotypic differences among populations in all the traits, which were little explained by latitude and macroclimate. In addition, the life history strategies (traits combined) hardly revealed any systematic difference related to latitude and macroclimate. The overall performance of the northernmost population from the most stochastic microclimate and the southernmost population, which remains active throughout the year, was least sensitive to the temperature treatments. In contrast, performance of the population from the most predictable microclimate peaked within a narrow temperature range (around 15°C). Our findings revealed limited support for macroclimate‐based predictions, and indicated that local soil habitat conditions related to predictability and seasonality might have considerable influence on the evolution of life history strategies of F. quadrioculata. This study highlights the need to combine knowledge on microhabitat characteristics, and demography, with findings from common garden experiments, for identifying the key drivers of life history evolution across large spatial scales, and wide climate gradients. We believe that similar approaches may substantially improve the understanding of adaptation in many terrestrial ectotherms with low dispersal ability.

show abstract

Cellular basis and developmental timing in a size cline of Drosophila melanogaster.

Cited by 249 publications

References 59 publications

Allelic polymorphism at foxo contributes to local adaptation in Drosophila melanogaster

Allelic polymorphism at foxo contributes to local adaptation in Drosophila melanogaster

Life history evolution and cellular mechanisms associated with increased size in high‐altitude Drosophila

Thermal plasticity in postembryonic life history traits of a widely distributed Collembola: Effects of macroclimate and microhabitat on genotypic differences

Contact Info

Product

Resources

About