Abstract:The extreme demand on health systems due to the COVID-19 pandemic has led to reconsider hypofractionation. Although the best clinical effi cacy of these schemes is being demonstrated, the biological bases have not been established. Thus, after validating basic clinical parameters, through complementary in vitro models, we characterized the cellular and molecular mechanisms of hypofractionation protocols.Cell cultures of human lung cancer cell line A549 were irradiated with 0, 2, 4, 8, 12, 16 and 20 Gy. The cla… Show more
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