Cellular architecture of the mouse hippocampus: A quantitative aspect of chemically defined GABAergic neurons with stereology

Jinno, Shozo; Kosaka, Toshio

doi:10.1016/j.neures.2006.07.007

Cited by 127 publications

(144 citation statements)

References 100 publications

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“…The largest labeled cell were weakly immunoreactive in contrast to the strong staining of such cells in dogs (Hof et al, 1996a). A septotemporal increase in the density of parvalbumin-containing cells has also been observed in the mouse (Jinno and Kosaka, 2006) but not in the rat (Nomura et al, 1997). Parenthetically, we did not observe parvalbumin-positive CA3 pyramidal cells which, so far, appear unique to dogs (Hof et al, 1996a).…”

Section: Neurochemistrycontrasting

confidence: 50%

A morphologically distinct granule cell type in the dentate gyrus of the red fox correlates with adult hippocampal neurogenesis

Amrein¹,

Slomianka²

2010

Brain Research

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A morphologically distinct granule cell type in the dentate gyrus of the red fox correlates with adult hippocampal neurogenesis Running titleThe dentate gyrus of the red fox Text pages 37Figures 7 Tables 3 Corresponding authorIrmgard In summary, we report a morphologically distinct granule cell type which correlates with adult 3 hippocampal neurogenesis in the fox. Furthermore, the maturation phase of the young neurons may be prolonged as in other long-living species such as primates. SECTIONNervous System Development, Regeneration and Aging

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Section: Neurochemistrycontrasting

confidence: 50%

A morphologically distinct granule cell type in the dentate gyrus of the red fox correlates with adult hippocampal neurogenesis

Amrein¹,

Slomianka²

2010

Brain Research

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“…The different classes of inhibitory neurons can be recognized on the basis of their morphological, molecular, and physiological features. Among these GABA interneurons, those expressing the calcium binding protein calretinin represent a small percent, about 10% [31], however, they play a crucial role regulating the activity of other GABAergic inhibitory interneurons and subsequently the excitatory action of principal cells [19]. The targets of CR-axons are interneurons (containing VIP, calbindin, or somatostatin) which terminate on different somatodendritic domains of principal cells.…”

Section: Discussionmentioning

confidence: 99%

“…Scale bars: 100 µm (A1-A3, B1 and B2); 20 µm (C). stratum radiatum has been reported to contain higher proportion of CR interneurons than stratum oriens [31]. Stereological counts (Fig.…”

Section: The Reduced Number Of Cr-positive Interneurons Was Consequenmentioning

confidence: 94%

Calretinin Interneurons are Early Targets of Extracellular Amyloid-β Pathology in PS1/AβPP Alzheimer Mice Hippocampus

Baglietto‐Vargas

Moreno-González

Sánchez-Varo

et al. 2010

JAD

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Abstract. Specific neuronal networks are preferentially affected in the early stages of Alzheimer's disease (AD). The distinct subpopulations of hippocampal inhibitory GABAergic system have been shown to display differential vulnerability to neurodegeneration in AD. We have previously reported a substantial loss of SOM/NPY interneurons, whereas those expressing parvalbumin were unaltered, in the hippocampus of 6 month-old PS1/AβPP transgenic mice. In the present study, we now investigated the pathological changes of hippocampal calretinin (CR) interneurons in this PS1/AβPP model from 2 to 12 months of age. The total number of CR-immunoreactive inhibitory cells was determined by stereology in CA1 and CA2/3 subfields. Our findings show a substantial decrease (35%-45%) of CR-positive interneurons in both hippocampal subfields of PS1/AβPP mice at very early age (4 months) compared to age-matched control mice. This decrease was accompanied by a reduced CR mRNA content as determined by quantitative RT-PCR. However, the number of another hippocampal CR-positive population (belonging to Cajal-Retzius cells) was not affected. The selective early loss of CR-interneurons was parallel to the appearance of extracellular Aβ deposits, preferentially in CR-axonal fields, and the formation of dystrophic neurites. This specific GABAergic subpopulation plays a crucial role in the generation of synchronous rhythmic activity in hippocampus by controlling other interneurons. Therefore, early alterations of hippocampal inhibitory functionality in AD, caused by select CR-cells neurodegeneration, could result in cognitive impairments seen in initial stages of the disease.

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“…Studies have shown that nNOS is expressed in interneurons in different regions of the mouse brain, with the highest density in the dentate gyrus [61] .…”

Section: Nitri C Oxide Synthase and Epilepsymentioning

confidence: 99%

Dysfunction of hippocampal interneurons in epilepsy

Liu

et al. 2014

Neurosci. Bull.

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Gamma-amino-butyric acid (GABA)-containing interneurons are crucial to both development and function of the brain. Down-regulation of GABAergic inhibition may result in the generation of epileptiform activity. Loss, axonal sprouting, and dysfunction of interneurons are regarded as mechanisms involved in epileptogenesis. Recent evidence suggests that network connectivity and the properties of interneurons are responsible for excitatory-inhibitory neuronal circuits. The balance between excitation and inhibition in CA1 neuronal circuitry is considerably altered during epileptic changes. This review discusses interneuron diversity, the causes of interneuron dysfunction in epilepsy, and the possibility of using GABAergic neuronal progenitors for the treatment of epilepsy.

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Cellular architecture of the mouse hippocampus: A quantitative aspect of chemically defined GABAergic neurons with stereology

Cited by 127 publications

References 100 publications

A morphologically distinct granule cell type in the dentate gyrus of the red fox correlates with adult hippocampal neurogenesis

A morphologically distinct granule cell type in the dentate gyrus of the red fox correlates with adult hippocampal neurogenesis

Calretinin Interneurons are Early Targets of Extracellular Amyloid-β Pathology in PS1/AβPP Alzheimer Mice Hippocampus

Dysfunction of hippocampal interneurons in epilepsy

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