Cellular angiofibroma of the orbit

Abstract

Cellular angiofibroma is a benign mesenchymal tumor most commonly located in the distal genital tract of both men and women. Although extragenital locations have been reported rarely, this is the first report of cellular angiofibroma of the orbit. A 58-year-old man presented with a mass in the left superomedial orbit since 2 years. Magnetic resonance imaging showed a well-demarcated lesion with a homogeneous intermediate signal intensity on both T1-and T2-weighted images, homogeneous contrast enhancement and high signal intensity on diffusion-weighted images. Complete excision was performed through a medial upper eyelid crease incision. Histopathology showed a vascular CD34-positive and STAT6-negative spindle cell tumor with monoallelic loss of FOXO1, indicating cellular angiofibroma.

Surgical excision of giant vulvar angiofibroma: A case report and a review of literature

“…[8] The youngest report of vulvar CA was from a 20-year-old patient with additional lesions on the axilla and breast. [9] In addition, the most recent peculiar site is CA of the orbit as described by Hötte et al [10]…”

“…[8] The youngest of vulvar CA was from a 20-year-old patient with additional lesions on the axilla and breast. [9] In addition, the most recent peculiar site is CA of the orbit as described by Hötte et al [10] As for the clinical features of CA, patients usually present with a slowly-growing mass that is otherwise asymptomatic. [3] Discomfort and difficulty moving may occur in lesions of the external genitalia that have reached a substantial size as in the case under study.…”

Diffusion-Weighted Imaging of the Orbit: A Case Series and Systematic Review

“…[33][34][35] While one study described their appearance on DWI as a slightly heterogenous isointense signal, others described it as mild hyperintensity. Other reports of DWI findings for specific tumors in the literature have included a cellular angiofibroma of the orbit, a mesenchymal tumor, with high intensity on DWI 36 , and a rare intraorbital granular cell tumor, arising from Schwann cells, which did not have diffusion restriction and appeared isointense on the ADC map consistent with a benign lesion. 37 Studies specific to pediatric populations have had similar findings when comparing malignant and benign orbital lesions and also determined ADC thresholds with high specificity and sensitivity (Tables 2 and 3).…”