Abstract:Several studies suggest that the decline of muscle function with age can be mitigated by dietary supplementation with beta‐hydroxy‐beta‐methylbutyrate (HMB) or beta‐alanine (BA). The purposes of this study were to investigate the effects of: 1) HMB treatment on murine C2C12 myoblast and myotube cultures; and 2) dietary HMB, BA, and a combination thereof, on muscle contractility in late middle‐aged mice. In C2C12 myotubes, free acid HMB enhanced sarcoplasmic reticulum (SR) calcium release beyond vehicle control… Show more
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