Cellular and molecular pathology of gastric carcinoma and precursor lesions: A critical review

Ming, Si-Chun

doi:10.1007/s101200050053

Cited by 96 publications

(92 citation statements)

References 115 publications

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“…Intestinal-type GC is thought to develop from IM by transdifferentiation, whereas diffuse-type GC is derived from stem cell or the pit cell precursor (Ming, 1998;Yuasa, 2003). Therefore, genes specifically expressed in the diffuse-type may be expressed preferentially in the pit region among the three regions of the gastric mucosa.…”

Section: Normal Gastric Pit Cells and Diffuse-type Gcs Possess Mesencmentioning

confidence: 99%

Cross talk between hedgehog and epithelial–mesenchymal transition pathways in gastric pit cells and in diffuse-type gastric cancers

Ohta

Aoyagi²,

Fukaya³

et al. 2008

Br J Cancer

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We previously reported hedgehog (Hh) signal activation in the mucus-secreting pit cell of the stomach and in diffuse-type gastric cancer (GC). Epithelial -mesenchymal transition (EMT) is known to be involved in tumour malignancy. However, little is known about whether and how both signallings cooperatively act in diffuse-type GC. By microarray and reverse transcription -PCR, we investigated the expression of those Hh and EMT signalling molecules in pit cells and in diffuse-type GCs. How both signallings act cooperatively in those cells was also investigated by the treatment of an Hh-signal inhibitor and siRNAs of Hh and EMT transcriptional key regulator genes on a mouse primary culture and on human GC cell lines. Pit cells and diffuse-type GCs co-expressed many Hh and EMT signalling genes. Mesenchymal-related genes (WNT5A, CDH2, PDGFRB, EDNRA, ROBO1, ROR2, and MEF2C) were found to be activated by an EMT regulator, SIP1/ZFHX1B/ZEB2, which was a target of a primary transcriptional regulator GLI1 in Hh signal. Furthermore, we identified two cancer-specific Hh targets, ELK1 and MSX2, which have an essential role in GC cell growth. These findings suggest that the gastric pit cell exhibits mesenchymal-like gene expression, and that diffuse-type GC maintains expression through the Hh -EMT pathway. Our proposed extensive Hh -EMT signal pathway has the potential to an understanding of diffusetype GC and to the development of new drugs.

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Section: Normal Gastric Pit Cells and Diffuse-type Gcs Possess Mesencmentioning

confidence: 99%

Cross talk between hedgehog and epithelial–mesenchymal transition pathways in gastric pit cells and in diffuse-type gastric cancers

Ohta

Aoyagi²,

Fukaya³

et al. 2008

Br J Cancer

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“…25 Surprisingly, serrated adenomas have not been found in the aforementioned classifications of gastric adenomas. 26 One possibility is that gastric serrated adenomas have been classified together with gastric villous adenomas. Another possibility is that this type of lesion is very rare in the stomach.…”

Section: Figure 7 Abrupt Border Between the Normal Gastric Mucosa Andmentioning

confidence: 99%

Serrated neoplasia of the stomach: a new entity

Rubio¹

2001

Journal of Clinical Pathology

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Aim-Despite the fact that gastric carcinoma continues to be one of the most common cancers world wide, only dysplasia in flat mucosa and adenomas have been shown to evolve into invasive carcinoma. The aim of this paper is to report a novel histological phenotype of gastric adenoma with early invasive growth. Material and results-The patient presented with gastric complaints. A barium examination revealed an ulcerated tumour in the corpus, apparently infiltrating the gastric wall. The endoscopic examination showed a pediculated protruding tumour in the greater curvature. Punch biopsies were reported as invasive adenocarcinoma. Because of the poor condition of the patient, a partial gastrectomy was performed. The histological examination revealed elongated fronds with lateral crenated, saw tooth-like notches as a result of scalloped epithelial indentations. Areas with high grade dysplasia, with carcinoma in situ, and invasive carcinoma at the tip of the adenoma were demonstrated. The pedicle of the protruding neoplasia "emerged" from a non-protruding serrated adenoma. Conclusions-The protruding serrated neoplasia had apparently evolved from a non-protruding serrated gastric adenoma. This appears to be the first case of gastric serrated neoplasia in the literature. (J Clin Pathol 2001;54:849-853)

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“…Intestinal gastric carcinoma (IGCA) and diffuse (DGCA) forms are the two main morphological types of gastric carcinoma (GCA) [1][2][3]. These tumor types diverge in many demographic and clinical characteristics [4,5].…”

Section: Introductionmentioning

confidence: 99%

Differences in genomic instability between intestinal- and diffuse-type gastric cancer

Vauhkonen

Sajantila

et al. 2005

Gastric Cancer

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Cellular and molecular pathology of gastric carcinoma and precursor lesions: A critical review

Cited by 96 publications

References 115 publications

Cross talk between hedgehog and epithelial–mesenchymal transition pathways in gastric pit cells and in diffuse-type gastric cancers

Cross talk between hedgehog and epithelial–mesenchymal transition pathways in gastric pit cells and in diffuse-type gastric cancers

Serrated neoplasia of the stomach: a new entity

Differences in genomic instability between intestinal- and diffuse-type gastric cancer

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