Cellular and molecular mechanisms of vitamin D in food allergy

Poole, Ashlyn; Song, Yong; Brown, Helen; Hart, Prue H.; Zhang, Guicheng

doi:10.1111/jcmm.13607

Cited by 44 publications

(40 citation statements)

References 88 publications

(253 reference statements)

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“…CD4 1 FoxP3 1 Treg cell populations both in spleen and MLN were not significantly changed by the cholecalciferol treatment, indicating that cholecalciferol was not effective in creating Treg-induced tolerance for reducing diarrhea in our mouse model. This result was also shown elsewhere that vitamin D3 did not affect Treg cells (14). In anti-CD69 mAb treated mice, we did not observe any changes in FoxP3 1 CD4 1 T cell population.…”

Section: Discussionsupporting

confidence: 91%

Effect of Cholecalciferol in Food Allergy Mouse Model Is Associated with Decrease of CD69+ CD4+ T Cells

Zaim

Ashino

Osaka

et al. 2019

J Nutr Sci Vitaminol

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Food allergy prevalence is increasing all over the world. Recent epidemiologic studies have shown the link between vitamin D3 insufficiency and food allergy occurrence. In this study, we investigated the effect of supplementation with cholecalciferol, a widely used form of vitamin D3, on food allergy using an experimental mouse model. In wild-type BALB/c mice which were sensitized and challenged with an experimental allergen, ovalbumin, a clinical symptom of food allergy, diarrhea, was significantly induced with the elevation of immunoglobulin E level and the increases of T helper 2 cytokine productions, such as interleukin-4,-5, and-13 (p,0.05), whereas no change in T helper 1 cytokine production, such as interferon-g, was observed. It was also found that cell population of CD69 1 CD4 1 T cells was increased slightly in spleen and significantly in the mesenteric lymphnode with the diarrheal symptom (p,0.05). Treatment of cholecalciferol reduced the allergic diarrhea (p,0.05) with the decreasing tendency of CD69 1 CD4 1 T cells, suggesting that the cell population might be associated with the attenuating effect of cholecalciferol on diarrhea occurrence, although immunoglobulin E levels and cytokine productions were not significantly altered by the treatment of cholecalciferol. When given the mice anti-CD69 mAb treatment, significant improvement of allergic diarrhea symptom was observed (p,0.05), accompanying the decrease of CD69 1 CD4 1 T cells which suggested the contribution of these cells to the diarrhea symptom. Taken together, we suggest that administration of cholecalciferol might be useful to suppress symptomatic food allergy in association with the decrease of CD69 1 CD4 1 T cells.

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Section: Discussionsupporting

confidence: 91%

Effect of Cholecalciferol in Food Allergy Mouse Model Is Associated with Decrease of CD69+ CD4+ T Cells

Zaim

Ashino

Osaka

et al. 2019

J Nutr Sci Vitaminol

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“…Several studies investigated the relationship between vitamin D deficiency and allergic diseases and concluded that low level of vitamin D is associated with increased incidence of allergies and asthma [16,17,18]. Poole et al [19] in their study conducted on infants showed that vitamin D insufficiency is associated with an increased risk of a challenge-proven peanut/egg allergy. Quirk et al [20] suggest that vitamin D deficiency increases the risk of sensitization to food allergens, particularly to milk and wheat.…”

Section: Discussionmentioning

confidence: 99%

Dependence of the allergic status markers on the level of vitamin D in the serum

Dajic

Stojkovic²,

Novkovic

et al. 2019

Srp Arh Celok Lek

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Introduction/Objective Recent researches show a link between low vitamin D serum levels and increased prevalence of allergic disease. The objective of this study was to show whether there is any dependence of the allergic status markers: skin prick test (SPT), total immunoglobulin E IgE (tIgE), and allergen-specific IgE (sIgE ≥ 3 class) in serum from the serum 25(OH)D (vitDs) level in children with allergic disease/s. Methods A total of 150 children with allergic disease/s were enrolled into this study. The vitDs, tIgE, SPT, and sIgE ≥ 3 class for aeroallergens and common food allergens were simultaneously assessed. Results We found a negative correlation between vitDs level and age groups and a statistically significant positive correlation between vitDs level and tIgE, sIgE ≥ 3 class for hen's egg yolk and hen's egg white. A statistically significant positive correlation was determined between vitDs level and SPT on Dermatophagoides pteronyssinus, and a negative correlation between tIgE and SPT on Dermatophagoides pteronyssinus, as well as between vitDs level and sIgE ≥ 3 class for Cladosporium and Alternaria molds. We confirmed the dependence of nettle rash and comorbidity asthma from the vitamin D insufficiency and vitamin D deficiency. We did not find any dependence of serum tIgE on vitDs level for the sample. Conclusion In order to get an adequate insight into the allergic status in children, we must take into account the pleotropic effects of vitamin D, according to which we suggest that, in the future, vitDs level should be determined synchronously with known markers of allergic status.

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“…In our study higher vitamin D levels were positively associated with protection from food allergy development. An U-shaped association between 25-hydroxyvitamin D and IgE level has been suggested [ 14 , 21 , 22 ]. Vitamin D has an essential impact on the immune system and allergy development via many mechanistic pathways [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

“…Taking vitamin D as an example, controversial findings regarding impact on allergy development have been published. Poole and colleagues studied the epigenetic, genetic and cellular modulations of vitamin D concluding that numerous mechanisms might contribute to the positive impact of Vitamin D on allergy prevention [ 14 , 15 , 16 , 17 ]. In contrast, high levels of vitamin D by extensive maternal supplementation during pregnancy, birth, lactation or due to supplementation in early childhood was reported to be associated with enhanced allergen sensitizations [ 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, high levels of vitamin D by extensive maternal supplementation during pregnancy, birth, lactation or due to supplementation in early childhood was reported to be associated with enhanced allergen sensitizations [ 18 , 19 , 20 ]. Thus, there seems to be an U-shaped association between 25-hydroxyvitamin D (the active component of vitamin D) and IgE levels with either too low or too high levels of vitamin D being associated with allergy susceptibility [ 14 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

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Mouse Chow Composition Influences Immune Responses and Food Allergy Development in a Mouse Model

et al. 2018

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Our diet is known to substantially influence the immune response not only by support of mucosal barriers but also via direct impact on immune cells. Thus, it was of great interest to compare the immunological effect of two mouse chows with substantial differences regarding micro-, macronutrient, lipid and vitamin content on the food allergic response in our previously established mouse model. As the two mouse chows of interest, we used a soy containing feed with lower fatty acid (FA) amount (soy-containing feed) and compared it to a soy free mouse chow (soy-free feed) in an established protocol of oral immunizations with Ovalbumin (OVA) under gastric acid suppression. In the animals receiving soy-containing feed, OVA-specific IgE, IgG1, IgG2a antibody levels were significantly elevated and food allergy was evidenced by a drop of body temperature after oral immunizations. In contrast, mice on soy-free diet had significantly higher levels of IL-10 and were protected from food allergy development. In conclusion, soy-containing feed was auxiliary during sensitizations, while soy-free feed supported oral tolerance development and food allergy prevention.

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Cellular and molecular mechanisms of vitamin D in food allergy

Cited by 44 publications

References 88 publications

Effect of Cholecalciferol in Food Allergy Mouse Model Is Associated with Decrease of CD69<sup>+</sup> CD4<sup>+</sup> T Cells

Effect of Cholecalciferol in Food Allergy Mouse Model Is Associated with Decrease of CD69<sup>+</sup> CD4<sup>+</sup> T Cells

Dependence of the allergic status markers on the level of vitamin D in the serum

Mouse Chow Composition Influences Immune Responses and Food Allergy Development in a Mouse Model

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