Cellular and Molecular Mechanisms in Oxidative Stress-Related Diseases 2.0/3.0

Remigante, Alessia; Morabito, Rossana

doi:10.3390/ijms242116018

IJMS

2023

DOI: 10.3390/ijms242116018

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Cellular and Molecular Mechanisms in Oxidative Stress-Related Diseases 2.0/3.0

Alessia Remigante,

Rossana Morabito

Abstract: Oxidative stress is frequently described as the balance between the production of reactive species (including oxygen and nitrogen) in biological systems and the ability of the latter to defend itself through the sophisticated antioxidant machinery [...]

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2024

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Antioxidant insights: investigating the protective role of oxidative balance in inflammatory bowel disease

Li,

Chang,

Wang

et al. 2024

Front. Endocrinol.

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BackgroundLimited studies have investigated the relationship between systemic oxidative stress and inflammatory bowel disease (IBD). The purpose of this study was to explore the relationship between oxidative balance score (OBS) and IBD.MethodsWe included 175,808 participants from the UK Biobank database from 2006 to 2010. OBS scores were calculated based on 22 lifestyle and dietary factors. Multiple variable Cox proportional regression models, as well as gender stratification and subgroup analysis, were utilized to investigate the relationship between OBS and IBD.ResultsThere is a significant negative correlation between OBS and the occurrence of IBD, ulcerative colitis (UC), and Crohn’s disease (CD). Additionally, OBS is significantly negatively correlated with intestinal obstruction in CD patients. Gender stratified analysis suggest a significant correlation between OBS and CD in female patients, particularly pronounced in those under 60 years old. Sensitivity analysis indicates a significant negative correlation between lifestyle-related OBS and diet-related OBS with the occurrence of CD in females, diet-related OBS is negatively correlated with CD in males.ConclusionOBS showed a significant negative correlation with IBD, especially in female CD patients. This study underscores the importance of antioxidant diet and lifestyle, which may provide a greater advantage for female CD patients.

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Antioxidant insights: investigating the protective role of oxidative balance in inflammatory bowel disease

Li,

Chang,

Wang

et al. 2024

Front. Endocrinol.

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show abstract

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Cellular and Molecular Mechanisms in Oxidative Stress-Related Diseases 2.0/3.0

Abstract: Oxidative stress is frequently described as the balance between the production of reactive species (including oxygen and nitrogen) in biological systems and the ability of the latter to defend itself through the sophisticated antioxidant machinery [...]

Cited by 1 publication

References 31 publications

Antioxidant insights: investigating the protective role of oxidative balance in inflammatory bowel disease

Antioxidant insights: investigating the protective role of oxidative balance in inflammatory bowel disease

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