Cellular and molecular investigations into the development of the pectoral girdle

Valášek, Petr; Theis, Susanne; DeLaurier, April; Hinits, Yaniv; Luke, Graham; Otto, Anthony; Minchin, James E.N.; He, Lian; Christ, Bodo; Brooks, Gavin; Sang, Helen; Evans, Darrell John Rhys; Logan, Malcolm; Huang, Ruijin; Patel, Ketan

doi:10.1016/j.ydbio.2011.06.031

Cited by 70 publications

(103 citation statements)

References 40 publications

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“…In vertebrates, skeletal muscles which form in the head, trunk and limbs are patterned by extrinsic cues from surrounding tissues to adopt specific arrangements of muscle fibres in the adult form [23][24][25][26][27][28][29][30][31] . For example, somite-derived limb muscle precursor cells migrate into the limb bud which is filled with lateral platederived connective tissue.…”

Section: Discussionmentioning

confidence: 99%

The developmental basis of bat wing muscle

2012

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By acquiring wings, bats are the only mammalian lineage to have achieved flight. To be capable of powered flight, they have unique muscles associated with their wing. However, the developmental origins of bat wing muscles, and the underlying molecular and cellular mechanisms are unknown. Here we report, first, that the wing muscles are derived from multiple myogenic sources with different embryonic origins, and second, that there is a spatiotemporal correlation between the outgrowth of wing membranes and the expansion of wing muscles into them. Together, these findings imply that the wing membrane itself may regulate the patterning of wing muscles. Last, through comparative gene expression analysis, we show Fgf10 signalling is uniquely activated in the primordia of wing membranes. Our results demonstrate how components of Fgf signalling are likely to be involved in the development and evolution of novel complex adaptive traits.

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Section: Discussionmentioning

confidence: 99%

The developmental basis of bat wing muscle

2012

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“…As described by Paterson (1900) and Gladstone andWakley (1932), andHanson (1919), the sternal bands seemed to be formed by the joining of mesenchymal condensations adjacent to the anterior ends of the ribs. The sternal bands are characterized by their attachment to anlage of the sternocostal portion of the pectoral major muscle (Gladstone and Wakeley, 1932): this morphology has been used as evidence to support the appendicular origin of the sternum in experimental embryology (Saunders, 1948;Seno, 1961;Valasek et al, 2011). The fact that the sternal bands and pectoralis muscle did not reach the interclavicular mesenchyme in the initial stage also seems to suggest different origins of the manubrium and body of the sternum.…”

Section: Discussionmentioning

confidence: 99%

“…CL, clavicle; SB, sternal bands Although a demarcation between mesenchymal condensations does not always indicate a difference in origin, we believe that a precise description on the early stage of the fetal manubrium is first needed for the further discussion, including classical theories as well as molecular biology with its recent advances. The topographical anatomy between a mesenchymal condensation and a specific muscle anlage, such as that of the infrahyoid muscles, would provide a clue for a better understanding (Saunders, 1948;Seno, 1961;Matsuoka et al, 2005;Valasek et al, 2011). Consequently, the aim of this study was to revisit the development of the manubrium of the sternum to clarify the confusion.…”

Section: Introductionmentioning

confidence: 99%

“…The fact that the sternal abnormality is most likely to accompany the heart abnormality also suggests the common cue or origin from the neural crest (reviewed by Weston et al, 2006). By contrast, Valasek et al (2011) demonstrated a common factor (Tbx5) required for development of not only all limb elements but also the sternum. Thus, the sternum is likely to carry dual origins.…”

Section: Introductionmentioning

confidence: 99%

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Morphogenesis of the Manubrium of Sternum in Human Embryos: A New Concept

Rodríguez‐Vázquez¹,

Verdugo-López²,

Garrido³

et al. 2012

The Anatomical Record

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To revisit many theories on fetal development of the manubrium of the sternum, we examined 25 mid-term fetuses at 6-9 weeks of gestation. The initial developmental stage of the manubrium was characterized by a distinct interclavicular mesenchyme that was continuous with the developing clavicles. Because parts of the clavicle in which endochondral ossification occurs originate from the neural crest, the interclavicular mesenchyme seems to be of the same origin. The sternal bands, possibly of the lateral plate origin, were restricted at the anterior ends of the ribs in the paired thoracic walls. The interclavicular mesenchyme extended caudally and laterally to reach the anterior ends of the first ribs, and thus the interclavicular mesenchyme expanded into the intercostoclavicular mesenchyme. Then, the primitive manubrium was delimited by the sternoclavicular joint and its related ligaments, all of which developed from the interclavicular and intercostoclavicular mesenchymes. Although the first ribs were attached to the intercostoclavicular mesenchyme, the former was vimentinnegative in contrast to the latter, positive mesenchyme. Soon afterwards, the small upper end of the sternal bands was integrated into the intercostoclavicular mesenchyme to form the primitive manubrium. The infrahyoid muscles and their supplying nerves maintained a close topographical relation to the interclavicular or intercostoclavicular mesenchyme, whereas the pectoralis major muscle kept attachments to the sternal bands. Consequently, the manubrium of sternum appeared to develop in a complex way at a junction area between derivatives of the neural crest, lateral plate, and somite. Anat Rec, 296:279-289,

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“…This includes some muscles of the pelvic and pectoral girdles that develop from limb muscle cells that, having migrated into the limbs, then migrate out again to populate these regions. This is known as the 'in-out mechanism' Valasek et al 2011). Understanding the different origins and developmental processes that generate various muscle types will be important in designing interventions that target these muscles.…”

Section: Skeletal Musclementioning

confidence: 99%

Epigenetics and developmental programming of welfare and production traits in farm animals

Sinclair

Rutherford

Wallace

et al. 2016

Reprod. Fertil. Dev.

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Abstract. The concept that postnatal health and development can be influenced by events that occur in utero originated from epidemiological studies in humans supported by numerous mechanistic (including epigenetic) studies in a variety of model species. Referred to as the 'developmental origins of health and disease' or 'DOHaD' hypothesis, the primary focus of large-animal studies until quite recently had been biomedical. Attention has since turned towards traits of commercial importance in farm animals. Herein we review the evidence that prenatal risk factors, including suboptimal parental nutrition, gestational stress, exposure to environmental chemicals and advanced breeding technologies, can determine traits such as postnatal growth, feed efficiency, milk yield, carcass composition, animal welfare and reproductive potential. We consider the role of epigenetic and cytoplasmic mechanisms of inheritance, and discuss implications for livestock production and future research endeavours. We conclude that although the concept is proven for several traits, issues relating to effect size, and hence commercial importance, remain. Studies have also invariably been conducted under controlled experimental conditions, frequently assessing single risk factors, thereby limiting their translational value for livestock production. We propose concerted international research efforts that consider multiple, concurrent stressors to better represent effects of contemporary animal production systems.

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Cellular and molecular investigations into the development of the pectoral girdle

Cited by 70 publications

References 40 publications

The developmental basis of bat wing muscle

The developmental basis of bat wing muscle

Morphogenesis of the Manubrium of Sternum in Human Embryos: A New Concept

Epigenetics and developmental programming of welfare and production traits in farm animals

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