Cellular and molecular changes associated with fish oocyte ageing

Abstract

Post-ovulatory oocyte ageing in fish is associated with limited fertilization rate, poor embryo development, larval malformation, ploidy anomalies and various other offspring abnormalities. Many studies have focused on morphological, physiological, biochemical and histological changes that occur during oocyte ageing. However, little is known about molecular changes associated with this process. This review covers the cellular and molecular characteristics of ageing oocytes with special focus on age-associated changes affected by oxidative damage. The contribution of oxidative stress and mitochondrial dysfunction, as well as new insights into oocyte ageing in higher vertebrates, is discussed to provide direction for future studies. Investigating the genomics and proteomics of oocyte ageing, including underlying molecular mechanisms, could contribute valuable information on determinants of egg quality. Such knowledge can be translated into practical applications in aquaculture, such as supplementation of oocyte culture media with antioxidants and other agents as a means to inhibit or delay development of the aged oocyte phenotype. Identification of cellular and molecular markers associated with the oocyte ageing process will benefit such developments.

Early gonadal maturation and vitellogenin mRNA expression in Siberian sturgeon Acipenser baerii cultured in a semi-closed water recirculating system in Korea

“…Although we did not conduct detail monitoring in subsequent ages due to such large individual variations, we found that the oocyte growth in this phase seemed to be notably slow and even suspected to be almost halted. Only after reaching the age of 7 years, oocyte maturation is somewhat accelerated and such that 'caviar-like' oocytes are found in considerable numbers of females, implying that a certain biological signaling is essentially needed to trigger oocytes to enter the final maturation stage (Nagahama and Yamashita, 2008;Samarin et al, 2019). Unlike ovarian maturation, the process of testicular maturation was achieved relatively earlier without a lag interval intercepted between the initial and final maturation stages.…”

Aspectos Econômico Da Piscicultura Na Amazônia Brasileira

“…Free lysine (L-lysine• HCl) is utilized for growth less efficiently than protein-bound lysine (soybean meal) in practical diets by young channel catfish (Ictalurus punctatus). Aquaculture, 159 (1)(2), 87-100. DOI: https://doi.org/10.1016/S0044-8486(97)00184-1.…”

Oocyte Ageing in Zebrafish Danio rerio (Hamilton, 1822) and Its Consequence on the Viability and Ploidy Anomalies in the Progeny

“…Oocyte ageing appears to be a complex process involving multiple pathways. Some of the cellular and molecular changes associated with this ageing process have been investigated in fish [ 4 , 5 , 6 ], as well as in other vertebrates [ 7 , 8 ]. However, the precise pathways underlying oocyte ageing have yet to be sufficiently characterized.…”