Cellular and Molecular Basis for Antigen Transport Across Epithelial Barriers

Neutra, Marian R.; Kraehenbuhl, Jean–Pierre

doi:10.1016/b978-012491543-5/50011-5

Cited by 22 publications

(22 citation statements)

References 189 publications

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“…Although our knowledge of the ultrastructure of tight junctions has progressed during the last several years, the pathogenic mechanism of diseases where tight junctions are affected remained poorly understood, because of limited knowledge about their regulation. [19][20][21] The intestinal epithelium represents the primary site for active transport of fluid and electrolytes from the gut lumen through the transcellular pathway; however, the predominant route for passive transepithelial solute flow is the paracellular pathway. Gut mucosa serves as the main barrier to the passage of macromolecules, that is, foreign antigens entering the host via the oral route, components of commensal flora such as toxins.…”

Section: Innate Immune Mechanisms In Inflammatory and Autoimmune Procmentioning

confidence: 99%

Involvement of Innate Immunity in the Development of Inflammatory and Autoimmune Diseases

Tlaskalová‐Hogenová

Tučková

Štěpánková

et al. 2005

Annals of the New York Academy of Sciences

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Initial events and effector mechanisms of most inflammatory and autoimmune diseases remain largely unknown. Dysfunction of the innate and adaptive immune systems associated with mucosae (the major interface between the organism and its environment, e.g., microbiota, food) can conceivably cause impairment of mucosal barrier function and development of localized or systemic inflammatory and autoimmune processes. Animal models help in elucidating the etiology and pathogenetic mechanisms of human diseases, such as the inflammatory bowel diseases, Crohn's disease and ulcerative colitis, severe chronic diseases affecting the gut. To study the role of innate immunity and gut microbiota in intestinal inflammation, colitis was induced by dextran sulfate sodium (DSS) in mice with severe combined immunodeficiency (SCID). Conventionally reared (microflora-colonized) SCID mice displayed severe inflammation like that seen in immunocompetent Balb/c mice, whereas only minor changes appeared in the intestinal mucosa of DSS-fed gnotobiotic germ-free SCID mice. The presence of microflora facilitates the inflammation in DSS-induced colitis that develops in immunodeficient SCID mice, that is, in the absence of T and B lymphocytes. Celiac disease, a chronic autoimmune small bowel disorder, afflicts genetically susceptible individuals with wheat gluten intolerance. We showed that, in contrast with any other food proteins, wheat gliadin and its peptic fragments activate mouse macrophages and human monocytes to produce proinflammatory cytokines through the nuclear factor-kappaB signaling pathway. Activation of innate immunity cells by food proteins or components from gut microbiota thus could participate in the impairment of intestinal mucosa and the development of intestinal and/or systemic inflammation.

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Section: Innate Immune Mechanisms In Inflammatory and Autoimmune Procmentioning

confidence: 99%

Involvement of Innate Immunity in the Development of Inflammatory and Autoimmune Diseases

Tlaskalová‐Hogenová

Tučková

Štěpánková

et al. 2005

Annals of the New York Academy of Sciences

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“…The FMS were phagocytosed and transepithelially transported to Peyer's patch domes. The hydrophobic properties of polystyrene and latex beads have been noted to enable adherence and uptake by mammalian M-cells [14]. Presently, M-cells have not been characterised in channel catfish.…”

Section: Discussionmentioning

confidence: 98%

Fate of fluorescent microspheres in developing Ictalurus punctatus following prolonged immersion

Glenney

Petrie‐Hanson

2006

Fish & Shellfish Immunology

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“…Some recent dendritic cell observations include an ability to open tight junctions, extend processes, sample antigens and bacteria, and migrate to local lymphoid tissues ( Fig. 4) (49,50). PNAP constructs acquire the merits of both nano-and microparticulate delivery systems.…”

Section: Manufacture/characterizationmentioning

confidence: 97%

Inhaled Drug Delivery for Tuberculosis Therapy

2009

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One third of the world population is infected with tuberculosis (TB), and new infections occur at a rate of one per second. The recent increase in the emergence of drug-resistant strains of Mycobacterium tuberculosis and the dearth of anti-TB drugs is threatening the future containment of TB. New drugs or delivery systems that will stop the spread of TB and slow down or prevent the development of drug-resistant strains are urgently required. One of the reasons for the emergence of drug-resistant strains is the exposure of mycobacteria to sub-therapeutic levels of one or more antibiotics. Lung lesions containing large numbers of bacteria are poorly vascularized and are fortified with thick fibrous tissue; conventional therapy by the oral and parenteral routes may provide sub-therapeutic levels of anti-TB drugs to these highly sequestered organisms. Administering drugs by the pulmonary route to the lungs allows higher drug concentrations in the vicinity of these lesions. Supplementing conventional therapy with inhaled anti-TB therapy may allow therapeutic concentrations of drug to penetrate effectively into lung lesions and treat the resident mycobacteria.

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Cellular and Molecular Basis for Antigen Transport Across Epithelial Barriers

Cited by 22 publications

References 189 publications

Involvement of Innate Immunity in the Development of Inflammatory and Autoimmune Diseases

Involvement of Innate Immunity in the Development of Inflammatory and Autoimmune Diseases

Fate of fluorescent microspheres in developing Ictalurus punctatus following prolonged immersion

Inhaled Drug Delivery for Tuberculosis Therapy

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