Cellular and Ionic Mechanisms of Arterial Vasomotion

Cole, William C.; Gordon, Grant R.; Braun, Andrew P.

doi:10.1007/978-981-13-5895-1_12

Cited by 27 publications

(21 citation statements)

References 114 publications

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“…Vasomotion is the low-frequency oscillation of microvascular walls, which is principally myogenic and independent of heartbeat, respiration, and innervation. The synchronization of skin microvascular smooth muscle cells at the acupoint is believed to be related to rhythmic oscillation of calcium ions and intercellular gap junction [25,26]. The skin microvessels at different acupoints are not adjacent, whose synchronous vasomotion should have a different mechanism, such as under central control [16].…”

Section: Discussionmentioning

confidence: 99%

Skin microvascular vasomotion is synchronous at acupoints of beagle dogs

Zhang

et al. 2020

Preprint

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Background/purpose: Skin microvessels at acupoints have been documented to be more abundant and well-organized, and the synchronous microvascular vasomotion was detected at acupoints in our previous human study. This present study aimed to characterize the skin microvascular vasomotion at acupoints on the twelve meridians of beagle dogs. Materials and Methods: Two acupoints were selected on each meridian, and exactly located at the rosy red spots by an electrochemical color-appearing method, where the electrical resistance was measured. The skin blood flow at acupoints was recorded by laser Doppler flowmetry (LDF), and microvascular vasomotion was analyzed according to LDF waveforms. Results: The skin electrical resistance at acupoints was significantly lower than that at control non-acupoints. The LDF waveforms at acupoints was sinusoidal, which showed the synchronization of the microvascular vasomotion. The spectral analysis revealed that the vasomotion frequencies at acupoints on the same meridian were identical but not among different meridians, and the frequencies on the twelve main meridians displayed a constant order. Conclusion: The skin microvascular vasomotion is synchronous at acupoints of beagle dogs and has a specific frequency along the meridian, and the electrochemical color-appearing method is a feasible strategy for the precise and visual location of acupoints. The study provides evidence for the universality of synchronous vasomotion of skin microvessels at acupoints and contributes to clarifying the essence of acupoints and their effect mechanism.

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Section: Discussionmentioning

confidence: 99%

Skin microvascular vasomotion is synchronous at acupoints of beagle dogs

Zhang

et al. 2020

Preprint

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“…The synchronization of skin microvascular smooth muscle cells at the acupoint is believed to be related to rhythmic oscillation of calcium ions and intercellular gap junction. 22,23 The skin microvessels at different acupoints are not adjacent, whose synchronous vasomotion should have a different mechanism, such as under central control. 13 We think that more research is needed to investigate the microvascular properties, local microenvironment, and nerve supply.…”

Section: Discussionmentioning

confidence: 99%

Synchronous vasomotion of skin microvessels at acupoints on the twelve main meridians of beagle dogs

Zhang

et al. 2020

Skin Research and Technology

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Skin microvessels at acupoints and along meridians have been documented to be more abundant and more well-organized. 1-3 The unusual morphology suggests their close relation with acupoints and meridians and that they may have some particular functional characteristics. Higher microcirculation blood perfusion has been well characterized in some studies. 4,5 Vasomotion is the spontaneous rhythmic oscillation in microvascular diameter, independent of heartbeat, respiration, or nerve input, which at least regulates local blood flow and material exchanges between the vascular system and surrounding tissues. 6,7 However, as a functional status sign of microcirculation, microvascular vasomotion received little attention. Microvascular vasomotion is commonly measured using laser Doppler flowmetry (LDF), 8,9 and generally, its LDF waveforms are seemingly irregular. Interestingly, however, the sinusoidal waveforms of skin microvascular vasomotion were recorded at human acupoints in our previous studies. 10 We speculated that the special vasomotion

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“…For example, rhythmic relaxations and contractions of microvasculature, termed vasomotion ($0.1 Hz, range 0.05-0.3 Hz), are driven by the ''ultra-slow'' periodicity of intrinsic, resting-state neural activity (Martuzzi et al, 2009;Mateo et al, 2017;Mayhew et al, 1996). Here, microvasculature possess the molecular machinery for vasomotion (Aalkjaer et al, 2011;Cole et al, 2019), but the timing of the oscillations is entrained by neurons. Additionally, even slower fluctuations in CBF occur, which may be driven by ''infra-slow'' neural network rhythms (0.01-0.1 Hz) (Mitra et al, 2018;Monto et al, 2008), or more sporadically from systemic changes in blood CO 2 (Sassaroli et al, 2012;Wise et al, 2004) and blood pressure (Panerai et al, 1998).…”

Section: Introductionmentioning

confidence: 99%