Cellular and Humoral Immunity: a Distinction in Antigenic Recognition

Thompson, Karen; Harris, Martin; Benjamini, E.; Mitchell, Graham F.; Noble, Marion

doi:10.1038/newbio238020a0

Cited by 81 publications

(36 citation statements)

References 20 publications

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“…For example, (1) increasing acetoacetylation steadily destroys the ability of flagellin to initiate antibody production but enhances the capacity to induce flagellin-specific cellmediated immunity (Parish, 1971), (2) bovine serum albumin without adjuvant induces antibody production but no detectable delayed-type hypersensitivity (DTH), whereas under the same condition the protein conjugated with a lipid induces DTH against the unmodified protein but no detectable antibody production (Coon and Hunter, 1973), and (3) S-carboxymethylated lysozyme (CM -lysozyme) devoid of the three dimensional conformation of the native molecule fails to induce lysozymespecific antibody production but sustains the ability to induce lysozyme-specific DTH in guinea pigs (Thompson et al ., 1972). It is generally accepted that the antigenic determinant complementary to the antibody is recognized by B lymphocytes , while the antigenic area for carrier recognition in antibody production and that for DTH are recognized by T lymphocytes.…”

Section: Introductionmentioning

confidence: 99%

Cell-Mediated and Humoral Immunity in Mice: Cross Reaction Between Lysozyme and S-Carboxymethylated Lysozyme Studied by a Modified Footpad Test

Sugimoto

Kojima

Yaginuma

et al. 1975

JJMSB

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Section: Introductionmentioning

confidence: 99%

Cell-Mediated and Humoral Immunity in Mice: Cross Reaction Between Lysozyme and S-Carboxymethylated Lysozyme Studied by a Modified Footpad Test

Sugimoto

Kojima

Yaginuma

et al. 1975

JJMSB

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“…An implication of the present and other (25,26) studies that have used protein antigens to examine the fine specificity of T and B cells is that different structural requirements exist for the activation of these two cell populations. B cells and antibody specificities have been related to the recognition of conformationally determined epitopes on the antigen surface whereas T cells seem to recognize sequential determinants inscribed in the primary amino acid structure.…”

Section: Discussionmentioning

confidence: 99%

Differential major histocompatibility complex-related activation of idiotypic suppressor T cells. Suppressor T cells cross-reactive to two distantly related lysozymes are not induced by one of them.

Adorini¹,

Harvey²,

Rozycka-Jackson³

et al. 1980

The Journal of Experimental Medicine

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B10 (H-2b) mice are genetic nonresponders to hen egg-white lysozyme (HEL) and the distantly related human lysozyme (HUL). However, anti-HEL or anti-HUL primary antibody responses in vivo or in vitro can be obtained in B10 mice by immunization with the appropriate lysozyme coupled to erythrocytes. T cells able to suppress either anti-lysozyme plaque-forming cells (PFC) response are induced in B10 mice after immunization with HEL-complete Freund's adjuvant (CFA) or HUL-CFA. This cross-reactivity of HEL and HUL in the induction and the expression of suppressive activity is in marked contrast to their very low cross-reactivity at the PFC level. These results suggest that either HEL or HUL can stimulate a suppressor T cell which recognizes a particular epitope present on both lysozymes. Suppressor cells induced by HEL or HUL bear the same predominant idiotype found on the majority of anti-HEL antibodies, and on the small proportion of anti-HUL antibodies cross-reactive with HEL. B10.Q (H-2q) mice are responders in vivo to HEL-CFA, but not to HUL-CFA. In contrast to B10, HEL-CFA priming in B10.Q micr induces helper cells whereas HUL-CFA priming induces suppressor cells. These suppressor cells are cross-reactive with HEL and are fully able to suppress HEL-specific helper cells. The presence of HEL-specific suppressor cell precursors in B10.Q mice which are not activated by HEL, seems to implicate differential choice by the antigen presenting system as a basis for Ir gene control, rather than the absence of a regulatory cell type from the T cell repertoire.

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“…Reduction and carboxymethylation of lysozyme yielded a derivative which exhibited excellent cross-reactivity in delayed skin reactions, when tested with non-modified lysozyme or vice versa. Lysozyme and its derivative induced comparable humoral responses, but cross-reactivity of antibodies could not be established (Thomson et al, 1972).…”

mentioning

confidence: 89%

Chemical modification and immunogenicity of membrane fractions from mouse tumour cells

Staab¹,

Anderer²

1978

Br J Cancer

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Summary.-A crude membrane fraction isolated from mouse tumour cells was treated with various chemicals. The effects on the immunogenicity of the membrane sample were tested in syngeneic mice for tumour protection, using a challenge dose of 105 viable tumour cells. Best protection was obtained after immunization of mice with a membrane sample modified with dimethylsulphate. Up to 60% of the animals remained tumour free, and the tumour-bearing animals showed a greatly increased mean survival time. The post-challenge sera contained no detectable amounts of cytotoxic antibodies.The membrane sample isolated from tumour cells which had been modified with dimethylsulphate showed less immunogenicity than the modified cells or the membrane fraction from unmodified cells.

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Cellular and Humoral Immunity: a Distinction in Antigenic Recognition

Cited by 81 publications

References 20 publications

Cell-Mediated and Humoral Immunity in Mice: Cross Reaction Between Lysozyme and S-Carboxymethylated Lysozyme Studied by a Modified Footpad Test

Cell-Mediated and Humoral Immunity in Mice: Cross Reaction Between Lysozyme and S-Carboxymethylated Lysozyme Studied by a Modified Footpad Test

Differential major histocompatibility complex-related activation of idiotypic suppressor T cells. Suppressor T cells cross-reactive to two distantly related lysozymes are not induced by one of them.

Chemical modification and immunogenicity of membrane fractions from mouse tumour cells

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