Cellular and humoral immune status in women with chronic Candida vaginitis

Syverson, Rae Ellen; Buckley, Helen R.; Gibian, Judith R.; Ryan, George M.

doi:10.1016/0002-9378(79)90641-0

Cited by 63 publications

(35 citation statements)

References 12 publications

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“…To date, studies to examine host defense mechanisms against C. albicans vaginitis have employed both women with RVVC and experimental rodent models [15][16][17][18][19][20][21][22][23]. Although clinical and animal studies suggest that local, rather than systemic, CMI is more important against C. albicans vaginitis, each has not been without limitations.…”

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confidence: 99%

Differential Susceptibility of Two Species of Macaques to Experimental Vaginal Candidiasis

1999

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Vulvovaginal candidiasis (VVC) caused by Candida albicans is a significant problem in women of childbearing age. Unfortunately, protective host defense mechanisms against VVC are poorly understood. Although rodent models of experimental vaginal candidiasis have been useful, several differences from humans limit the correlation of experimental data. The purpose of the present study was to examine two species of macaques as an alternative model of experimental vaginitis. Screening of pig-tailed and rhesus macaques demonstrated that each had mucosal Candida colonization and prior immune sensitization to C. albicans. Vaginal-associated immunity (cytokines, antibodies, and innate resistance) was also detected in cervicovaginal lavage fluid from both species. Nevertheless, intravaginal inoculation of C. albicans into both species, either untreated or under estrogen-treated conditions, resulted in vaginal infection in rhesus, but not pig-tailed, macaques. Several estrogen-dependent changes in the rhesus immune status coincided with susceptibility to infection. Taken together, these results suggest that pig-tailed and rhesus macaques may be useful in studying pathogenesis and immunity associated with C. albicans vaginitis.

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confidence: 99%

Differential Susceptibility of Two Species of Macaques to Experimental Vaginal Candidiasis

1999

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“…An undefined immune deficiency or dysfunction is postulated to be responsible for RVVC (12,33,37). Although T-helper1 (Th1)-type cell-mediated immunity (CMI) is the predominant host defense mechanism against mucosal C. albicans infections (3,28,29), several clinical studies have demonstrated that most women experience RVVC despite normal levels of Candida-specific systemic Th1-type CMI (8,14,23,35).…”

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confidence: 99%

Cell Adhesion Molecule and Lymphocyte Activation Marker Expression during Experimental Vaginal Candidiasis

2001

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Cell-mediated immunity by Th1-type CD4؉ T cells is the predominant host defense mechanism against mucosal candidiasis. However, studies using an estrogen-dependent murine model of vaginal candidiasis have demonstrated little to no change in resident vaginal T cells during infection and no systemic T-cell infiltration despite the presence of Candida-specific systemic Th1-type responses in infected mice. The present study was designed to further investigate these observations by characterizing T-cell activation and cell adhesion molecule expression during primary and secondary C. albicans vaginal infections. While flow cytometry analysis of activation markers showed some evidence for activation of CD3 ؉ draining lymph node and/or vaginal lymphocytes during both primary and secondary vaginal Candida infection, CD3؉ cells expressing the homing receptors and integrins ␣ 4 ␤ 7 , ␣ M290 ␤ 7 , and ␣ 4 ␤ 1 in draining lymph nodes of mice with primary and secondary infections were reduced compared to results for uninfected mice. At the local level, few vaginal lymphocytes expressed integrins, with only minor changes observed during both primary and secondary infections. On the other hand, immunohistochemical analysis of vaginal cell adhesion molecule expression showed increases in mucosal addressin cell adhesion molecule 1 and vascular cell adhesion molecule 1 expression during both primary and secondary infections. Altogether, these data suggest that although the vaginal tissue is permissive to cellular infiltration during a vaginal Candida infection, the reduced numbers of systemic cells expressing the reciprocal cellular adhesion molecules may preempt cellular infiltration, thereby limiting Candida-specific T-cell responses against infection.

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“…The fungus can be isolated from the vagina of 6-28% of women, and this incidence is doubled in pregnancy [2,3]. Symptomatic vaginal candidiasis occurs in 15-43% of carriers [3,4]. A number of factors other than pregnancy favor the con version of C. albicans from commensal of the vagina to pathogen and are well known.…”

Section: Introductionmentioning

confidence: 99%

“…Among them are diabetes, oral antibiotic or steroid therapy, the ingestion of the contraceptive pill, and immunodeficient status [3][4][5]. The mechanism by which this conversion into the patho genic form takes place, and the changes which C. albi cans undergoes during this process, are largely unknown [5,6], However, some evidence exists indicating that host and fungal factors play an important role [2], Although antibody response to C. albicans has been studied both in sera and cervicovaginal secretions from patients with Candida vaginitis [4,[7][8][9][10][11], no studies have been done with purified antigens or techniques which reveal antibody responses against defined anti gens. The role of anti-C. albicans antibodies in the cervi covaginal secretions is not completely understood, but they could inhibit adherence of C. albicans to vaginal epithelial cells in a way similar to that demonstrated with oral epithelial cells [12].…”

Section: Introductionmentioning

confidence: 99%

Different Antibody Response againstCandidaalbicansCell Wall Antigens in Cervicovaginal Secretions of Patients with Vulvovaginal Candidiasis

Schneider

Vicandi

Regúlez

et al. 1990

Gynecol Obstet Invest

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Vaginal washings from 118 women were investigated by means of immunofluorescence for the presence of antibodies against Candidaalbicans. A significantly (p < 0.02) higher antibody titer was found in the samples from patients with clinically evident vulvovaginal candidiasis. Vaginal secretions from those patients with a positive culture for C. albicans were assayed by means of Western blotting. A distinct band pattern was found in the group of patients with a positive culture and the classical clinical picture of C. albicans vulvovaginitis.

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Cellular and humoral immune status in women with chronic Candida vaginitis

Cited by 63 publications

References 12 publications

Differential Susceptibility of Two Species of Macaques to Experimental Vaginal Candidiasis

Differential Susceptibility of Two Species of Macaques to Experimental Vaginal Candidiasis

Cell Adhesion Molecule and Lymphocyte Activation Marker Expression during Experimental Vaginal Candidiasis

Different Antibody Response againstCandidaalbicansCell Wall Antigens in Cervicovaginal Secretions of Patients with Vulvovaginal Candidiasis

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