Cellular and humoral coagulation profiles and occurrence of IVH in VLBW and ELWB infants

Duppré, Perrine; Sauer, Harald; Giannopoulou, Eleni Z.; Gortner, Ludwig; Nunold, Holger; Wagenpfeil, Stefan; Geisel, Jürgen; Stephan, B.; Meyer, Sascha

doi:10.1016/j.earlhumdev.2015.09.008

Cited by 36 publications

(51 citation statements)

References 36 publications

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“…8,9 However, derangements in activated partial thromboplastin time (APTT), international normalized ratio (INR), and prothrombin time (PT) have been associated with IVH in premature neonates. 10,11 While thrombocytopenia is common in premature neonates, 12 controversies exist on the role of platelet counts in IVH among the premature neonates. 13,14 Mean platelet volume (MPV) has been suggested to change due to inflammation induced by IVH, 13,15 and potentially other conditions, with investigations on MPV as an early marker for IVH having been reported.…”

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confidence: 99%

The Role of Platelets in Premature Neonates with Intraventricular Hemorrhage: A Systematic Review and Meta-Analysis

Grevsen

Hviid

Hansen

et al. 2019

Semin Thromb Hemost

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Intraventricular hemorrhage (IVH) affects up to 22% of extremely low birth weight neonates. Impaired coagulation might contribute to the pathogenesis of IVH. The aims of this study were to summarize the current knowledge on the role of platelet indices in premature neonates with IVH and to provide an overview of secondary hemostasis parameters as well as fibrinolysis in premature neonates with IVH. The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The databases PubMed, Embase, Scopus, and Web of Science were searched on March 7, 2019, without time restrictions. In total, 30 studies were included. Most studies investigated the significance of platelet counts and/or mean platelet volume (MPV). The meta-analysis showed that at day 1 of life, neither platelet count nor MPV differed significantly between neonates with or without IVH (standardized mean difference [SMD]: –0.15 × 109/L, 95% confidence interval [CI]: –0.37 to 0.07 and SMD: 0.22 fl, 95% CI: –0.07 to 0.51, respectively). However, platelet counts < 100 × 109/L were associated with an increased risk of IVH. Secondary hemostasis parameters did not differ between neonates with and without IVH. Fibrinolysis was only sparsely investigated. In conclusion, platelet counts < 100 × 109/L were associated with an increased risk of IVH in premature neonates. The impact of secondary hemostasis was only sparsely investigated but seemed to be minor, and the role of fibrinolysis in IVH in premature neonates needs further research. Whether reduced platelet function is associated with an increased risk of IVH in premature neonates remains to be investigated.

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confidence: 99%

The Role of Platelets in Premature Neonates with Intraventricular Hemorrhage: A Systematic Review and Meta-Analysis

Grevsen

Hviid

Hansen

et al. 2019

Semin Thromb Hemost

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“…An association between IUGR and ICH is still a matter of continuing investigation. Some studies 23 reported no association of neonatal brain injury with IUGR, whereas others found significantly higher percentage of infants with intraventricular hemorrhage in the IUGR group compared with controls. 24 Also, the effect of chorioamnionitis on ICH is not straightforward.…”

Section: Discussionmentioning

confidence: 95%

Postnatal Paraclinical Parameters Associated to Occurrence of Intracerebral Hemorrhage in Preterm Infants

et al. 2019

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Intracerebral hemorrhage (ICH) is the most frequent complication in postnatal development of preterm infants. The purpose of the present work is the statistical evaluation of seven standard paraclinical parameters and their association to the development of ICH. Clinical records of 265 preterm infants with gestational age (GA) 23 to 30 weeks were analyzed. According to ICH status, patients were divided into control (without ICH) and affected (with ICH) groups. Mean values of paraclinical parameters at each week of gestation were compared. Different ICH grades, periods before and after ICH were considered separately. Lower hematocrit, SaO2, and pH were statistically significant for preterm infants with 23 to 30 weeks GA and diagnosis of ICH relative to infants without ICH. Additionally, for preterm infants with 27 to 30 weeks GA, higher C-reactive protein, as well as lower values of thrombocytes were associated with the occurrence of ICH. Preterm infants with 23 to 26 weeks GA showed C-reactive protein values similar to those in the group without ICH and lower levels of thrombocytes after bleeding. Significant differences in paraclinical parameters between preterm infants with and without ICH may constitute useful indicators for closer clinical observation of preterm infants at risk of ICH.

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“…According to studies [2][3][4], the most important role is played by the deficient and immature cerebral autoregulation, leading to significant fluctuations in the cerebral blood flow (CBF), as a result of which the fragile, muscle-lacking blood vessels of the GM are destroyed. But also various inflammatory diseases that affect the deformability of red blood cells, as well as coagulation disorders were found to be associated with the occurrence of IVH [5,6].…”

Section: Introductionmentioning

confidence: 99%

Machine learning models for identifying preterm infants at risk of cerebral hemorrhage

et al. 2020

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Intracerebral hemorrhage in preterm infants is a major cause of brain damage and cerebral palsy. The pathogenesis of cerebral hemorrhage is multifactorial. Among the risk factors are impaired cerebral autoregulation, infections, and coagulation disorders. Machine learning methods allow the identification of combinations of clinical factors to best differentiate preterm infants with intra-cerebral bleeding and the development of models for patients at risk of cerebral hemorrhage. In the current study, a Random Forest approach is applied to develop such models for extremely and very preterm infants (23-30 weeks gestation) based on data collected from a cohort of 229 individuals. The constructed models exhibit good prediction accuracy and might be used in clinical practice to reduce the risk of cerebral bleeding in prematurity.

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Cellular and humoral coagulation profiles and occurrence of IVH in VLBW and ELWB infants

Cited by 36 publications

References 36 publications

The Role of Platelets in Premature Neonates with Intraventricular Hemorrhage: A Systematic Review and Meta-Analysis

The Role of Platelets in Premature Neonates with Intraventricular Hemorrhage: A Systematic Review and Meta-Analysis

Postnatal Paraclinical Parameters Associated to Occurrence of Intracerebral Hemorrhage in Preterm Infants

Machine learning models for identifying preterm infants at risk of cerebral hemorrhage

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