Cellular and developmental aspects of androgenetic alopecia

Jahoda, Colin A.B.

doi:10.1111/j.1600-0625.2007.00666.x

Cited by 178 publications

(14 citation statements)

References 348 publications

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“…Innate immunity in vitiligo bridges the gap between oxidative stress and adaptive immunity in vitiligo. It is likely that the activation of innate immune cells occurs early in vitiligo, by sensing exogenously or endogenously induced stress signals released from melanocytes and possibly keratinocyte [25, 76, 80]. As mentioned above, there is an association between vitiligo susceptibility and genetic changes in NALP1, a regulator of the innate immune system [42, 81].…”

Section: Pathogenesismentioning

confidence: 99%

Vitiligo: A Review

2020

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Vitiligo, a common depigmenting skin disorder, has an estimated prevalence of 0.5-2% of the population worldwide. The disease is characterized by the selective loss of melanocytes which results in typical nonscaly, chalky-white macules. In recent years, considerable progress has been made in our understanding of the pathogenesis of vitiligo which is now clearly classified as an autoimmune disease. Vitiligo is often dismissed as a cosmetic problem, although its effects can be psychologically devastating, often with a considerable burden on daily life. In 2011, an international consensus classified segmental vitiligo separately from all other forms of vitiligo, and the term vitiligo was defined to designate all forms of nonsegmental vitiligo. This review summarizes the current knowledge on vitiligo and attempts to give an overview of the future in vitiligo treatment.

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Section: Pathogenesismentioning

confidence: 99%

Vitiligo: A Review

2020

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“…There is progressive reduction of the duration of anagen phase of hair follicles on the frontal scalp area with each passage through the hair cycle. Other discovered physiological changes in AGA: dermal papilla cell reduction; thinning of the dermis; the sebaceous glands enlargement; connective tissue streamers presence; number of mast cells increased; and T-cell infiltration of follicular stem cell epithelium [21][22][23]. There are strong evidences that AGA is androgen signaling-dependent disease.…”

Section: Hair Follicle-related Signaling Pathways In Androgenic Alopeciamentioning

confidence: 99%

Androgenic Alopecia: Cross-Talk Between Cell Signal Transduction Pathways

Nesterova¹,

Yuryev²

2017

Hair and Scalp Disorders

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Signaling pathways that control coordination of hair follicle cells genetic program are the convenient model for explaining the hierarchy of intercellular interactions governing cyclic growth of hair. This chapter describes models of molecular signaling pathways specific to dermal papilla cells from balding human scalp in hair follicle cycle. These models include already published data, as well as information inferred from pathway analysis of microarray data and protein-protein interaction database. Interplay of androgenic-alopecia-related signaling pathways FGF, TGFB, BMP, and WNT, as well as cyclin-dependent kinases signaling, is shown.

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“…Several factors, including autoimmune, biochemical, genetic, neuronal and environmental, may interact to contribute to its development. [370][371][372] Although evidence indicates an important role for genetic factors, [373][374][375] it also seems that triggers such as trauma to the skin, hormonal changes and psychological distress may need to be present for the disease to become apparent. 376 A number of observations suggest that vitiligo is an autoimmune disease, such as its association with other autoimmune diseases (e.g.…”

Section: Causesmentioning

confidence: 99%

A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease

Kim

Batchelor

Bath‐Hextall

et al. 2016

Programme Grants Appl Res

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Programme Grants for Applied ResearchISSN 2050-4322 (Print) ISSN 2050-4330 (Online) This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/).Editorial contact: nihredit@southampton.ac.ukThe full PGfAR archive is freely available to view online at www.journalslibrary.nihr.ac.uk/pgfar. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.uk Criteria for inclusion in the Programme Grants for Applied Research journalReports are published in Programme Grants for Applied Research (PGfAR) if (1) they have resulted from work for the PGfAR programme, and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors. Programme Grants for Applied Research programmeThe Programme Grants for Applied Research (PGfAR) programme, part of the National Institute for Health Research (NIHR), was set up in 2006 to produce independent research findings that will have practical application for the benefit of patients and the NHS in the relatively near future. The Programme is managed by the NIHR Central Commissioning Facility (CCF) with strategic input from the Programme Director.The programme is a national response mode funding scheme that aims to provide evidence to improve health outcomes in England through promotion of health, prevention of ill health, and optimal disease management (including safety and quality), with particular emphasis on conditions causing significant disease burden.For more information about the PGfAR programme please visit the website: http://www.nihr.ac.uk/funding/programme-grants-forapplied-research.htm This reportThe research reported in this issue of the journal was funded by PGfAR as project number RP-PG-0407-10177. The contractual start date was in September 2008. The final report began editorial review in April 2014 and was accepted for publication in April 2016. As the funder, the PGfAR programme agreed the research questions and study designs in advance with the investigators. The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The PGfAR editors and production house have tried to ensure the accuracy of the authors' report and would like to thank the reviewers for their constructive comments on the final report document. However, they do not accept liability for damages or losses arising from material published in this report.This report presents independent research funded by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, CCF, NETSCC, PGfAR or the Department of Health. If there are verbatim quotations included in this publication the views and opinions expressed by the interviewees are those of the interviewees and do not necessarily reflect those of the authors, those of the NHS, the NIHR, ...

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Cellular and developmental aspects of androgenetic alopecia

Cited by 178 publications

References 348 publications

Vitiligo: A Review

Vitiligo: A Review

Androgenic Alopecia: Cross-Talk Between Cell Signal Transduction Pathways

A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease

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