Cellular alteration after experimental directional peripheral atherectomy

Gonschior, P.; Gerheuser, Florian; Erdemci, A.; Gonschior, G. M.; Mack, Brigitte; Nerlich, Andreas; Welsch, Ulrich; Höfling, B.

doi:10.1007/978-3-663-01942-8_30

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…This indicates the need for an antiproliferative prophylaxis of restenosis immediately after the primary intervention. 15,16 It should be kept in mind that atherectomy does not allow a direct recanalization of occlusions ; so a combination of dotter effect and plaque ablation was used in this study to recanalize occlusions.…”

Section: Discussionmentioning

confidence: 99%

Results of Directional Peripheral Atherectomy with Reference to Histology, Histochemistry, and Ultrastructure

Gonschior¹,

Höfling

Mack

et al. 1993

Angiology

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One hundred patients with symptomatic peripheral vascular disease were treated with a directional atherectomy catheter; 153 lesions comprising 98 stenoses and 55 occlusions were located in the iliac (n = 22), superficial femoral (n = 114), popliteal (n = 16), and anterior tibial (n = 1) arteries. The majority of these patients were poor candidates for balloon angioplasty because of the complexity of lesions. There were 70 eccentric and 28 concentric lesions and 55 occlusions (mean length 4.2 +/- 2.9 cm). Acute success rate was 94% for both stenoses and occlusions. Four patients were treated in both lower extremities. The stenoses were reduced from 85 +/- 12% to 12 +/- 10% acutely (occlusions 100% to 9 +/- 9%). Six-month angiographic follow-ups were performed in 81% of treated patients, the others refusing angiography. Mean stenosis after six months was 33 +/- 25% (occlusions 44 +/- 28%). Restenosis (> 50%) was found in 20% of treated lesions: 26% in concentric lesions, 8% in eccentric lesions, and 32% in occluded vessels. Treatment of peripheral vascular disease with the atherectomy device is safe and effective therapy with good long-term results. These results were obtained in complex lesions with 55 occlusions. Atherectomy seems to be particularly beneficial in the treatment of eccentric and complex stenoses and is not limited by occlusion or calcification. Furthermore, insight into the pathogenesis of arteriosclerosis and the development of restenosis is enabled by analysis of removed plaque material.

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Section: Discussionmentioning

confidence: 99%

Results of Directional Peripheral Atherectomy with Reference to Histology, Histochemistry, and Ultrastructure

Gonschior¹,

Höfling

Mack

et al. 1993

Angiology

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“…71 In addition, the rapid increase in HpD concentration upon local application makes it possible to use PDT to prevent restenosis after angioplasty without serious side-effects. 72 Neave et al proved that in comparison to the normal arterial wall, AS plaque took up more dihematoporphyrin ether (photofrin II), especially 48 hours after the injection, and the plaque showed significant reduction 6 weeks after PDT. 73 It is proved that morbid SMCs are more sensitive to PDT than healthy cells both in vitro and in vivo, confirming the feasibility of photofrin II-induced PDT.…”

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confidence: 99%

Recent Advances for Dynamic-Based Therapy of Atherosclerosis

Wu¹,

Yu²,

Zheng³

et al. 2023

IJN

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Atherosclerosis (AS) is a chronic inflammatory disease, which may lead to high morbidity and mortality. Currently, the clinical treatment strategy for AS is administering drugs and performing surgery. However, advanced therapy strategies are urgently required because of the deficient therapeutic effects of current managements. Increased number of energy conversion-based organic or inorganic materials has been used in cancer and other major disease treatments, bringing hope to patients with the development of nanomedicine and materials. These treatment strategies employ specific nanomaterials with specific own physiochemical properties (external stimuli: light or ultrasound) to promote foam cell apoptosis and cholesterol efflux. Based on the pathological characteristics of vulnerable plaques, energy conversion-based nano-therapy has attracted increasing attention in the field of anti-atherosclerosis. Therefore, this review focuses on recent advances in energy conversion-based treatments. In addition to summarizing the therapeutic effects of various techniques, the regulated pathological processes are highlighted. Finally, the challenges and prospects for further development of dynamic treatment for AS are discussed.

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Rotational Angioplasty and Directional Atherectomy to Treat Complex Lesions of the Right Coronary Artery

Gonschior

Nerlich

Bauriedel

et al. 1992

J Interven Cardiology

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A combination of interventional devices including the Rotablator and directional coronary atherectomy (DCA) was used to treat a 39-year-old patient with a complex lesion of the right coronary artery. The devices enabled the recanalization and reconstruction of the diseased vessel without laceration or dissection, leaving a smooth-edged segment. The histological analysis of the tissue obtained from DCA revealed no predictors of restenosis, like highly cellular material or media. Thus, combination of mechanical interventional devices allowed to treat a highly complex lesion without lacerating the vessel and leaving an excellent acute and long-term outcome.

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Cellular alteration after experimental directional peripheral atherectomy

Cited by 3 publications

References 14 publications

Results of Directional Peripheral Atherectomy with Reference to Histology, Histochemistry, and Ultrastructure

Results of Directional Peripheral Atherectomy with Reference to Histology, Histochemistry, and Ultrastructure

Recent Advances for Dynamic-Based Therapy of Atherosclerosis

Rotational Angioplasty and Directional Atherectomy to Treat Complex Lesions of the Right Coronary Artery

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