Cellular agriculture for milk bioactive production

Yart, Lucile; Wijaya, Andy Wiranata; Lima, Maria João; Haller, Corinne; van der Beek, Eline M.; Carvalho, Ryan S.; Kraus, Marine R.-C.; Mashinchian, Omid

doi:10.1038/s44222-023-00112-x

Cited by 4 publications

(5 citation statements)

References 222 publications

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“…Additionally, enhancing milk supply in livestock has broad implication for sustainable agriculture. Dairy is an emission-heavy product to begin with, and infant formulas have added emissions due to the intense manufacturing process, worldwide transportation, packaging, and additional water use 13,14,48,67–71 . Homologous fusions to Prolactin-XL could sustainably enhance milk production per animal to decrease the overall number of animals required to produce the same amount of milk.…”

Section: Discussionmentioning

confidence: 99%

“…Breastfeeding care-work builds people, families, friendships, and communities. There is universal consensus amongst scientists, clinicians, major health organizations, national governments, and the infant formula industry to protect and promote everyday breastfeeding 1–13 . As climate disasters are intensifying in scale, frequency and intensity, breastfeeding becomes even more life-and-death for vulnerable infants in emergencies 9,14 .…”

Section: Discussionmentioning

confidence: 99%

“…Breastfeeding is the biological norm and standard of care for every day infant nutrition worldwide 2 . There is universal consensus amongst scientists, clinicians, major health organizations, national governments, and the infant formula industry that breastfeeding is best for most infants 1–13 . Breastfeeding is also crucial for protecting vulnerable infants when there is no electricity, no safe water, disrupted supply chains, or infant formula shortages, contaminations, or recalls 9,14–18 .…”

Section: Introductionmentioning

confidence: 99%

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A long-acting prolactin to combat lactation insufficiency

Kready,

Doiron,

Redfield Chan

et al. 2023

Preprint

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Human infants are born to breastfeed. While 50% of lactating persons struggle to make enough milk, there are no governmentally-approved drugs to enhance lactation1. Here, we engineer a variant of the naturally-occurring driver of lactation, the hormone Prolactin, to increase its serum half-life and produce a viable drug candidate. Our engineered variant, Prolactin-eXtra Long-acting (Prolactin-XL), is comprised of endogenously active human prolactin fused to an engineered human IgG Fc domain designed to overcome the unique drug development challenges specific to the lactating person-infant dyad. Our Prolactin-XL has a serum half-life of 70.9h in mice, 2,625-fold longer than endogenously active prolactin alone (70.9h v. 0.027h). We demonstrate that Prolactin-XL increases milk production and restores growth of pups fed by dams with pharmacologically-ablated lactation. We show that Prolactin-XL-enhanced lactation is accompanied by reversible, lactocyte-driven changes in mammary gland morphology. This work establishes long-acting prolactins as a potentially powerful pharmacologic means to combat insufficient lactation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A long-acting prolactin to combat lactation insufficiency

Kready,

Doiron,

Redfield Chan

et al. 2023

Preprint

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show abstract

“…Recent studies also point to the therapeutic potential of lactoferrin in the treatment of neurodegenerative diseases related to aging and emotional disorders linked to stress [86,87]. Due to the widespread use of milk proteins in the food and nutrition industry, the production of these proteins by precision fermentation has emerged as an area of great interest [88][89][90][91]. This movement illustrates a global effort to reconcile human nutritional needs with environmental sustainability, paving the way for innovations that can offer sustainable alternatives to the consumption of milk and its derivatives of animal origin.…”

Section: Milk Proteinsmentioning

confidence: 99%

Precision Fermentation as an Alternative to Animal Protein, a Review

Knychala,

Boing,

Ienczak

et al. 2024

Preprint

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The global food production system faces several challenges, including significant environmental impacts due to traditional agricultural practices. The rising demands of consumers for food products that are safe, healthy, and have animal welfare standards have led to an increased interest in alternative proteins and the development of the cellular agriculture field. Within this innovative field, precision fermentation emerges as a promising technological solution to produce proteins with reduced ecological footprints. This review provides a summary of the environmental impacts related to the current global food production, and explore how precision fermentation can contribute to address these issues. Additionally, we will report on the main animal-derived proteins produced by precision fermentation, with a particular focus on those used in the food and nutraceutical industries. The general principles of precision fermentation will be explained, including strain and bioprocess optimization. Examples of efficient recombinant protein production by bacteria and yeasts, such as milk proteins, egg-white proteins, structural and flavoring proteins, will also be addressed, along with case examples of companies producing these recombinant proteins in a commercial scale. Through these examples, we will explore how precision fermentation supports sustainable food production and holds the potential for significant innovations in the sector.

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“…Recent studies also point to the therapeutic potential of lactoferrin in the treatment of neurodegenerative diseases related to aging and emotional disorders linked to stress [114,115]. Due to the widespread use of milk proteins in the food and nutrition industry, the production of these proteins by precision fermentation has emerged as an area of great interest [116][117][118][119]. This movement illustrates a global effort to reconcile human nutritional needs with environmental sustainability, paving the way for innovations that can offer sustainable alternatives to the consumption of milk and its derivatives of animal origin.…”

Section: Milk Proteinsmentioning

confidence: 99%

Precision Fermentation as an Alternative to Animal Protein, a Review

Knychala,

Boing,

Ienczak

et al. 2024

Fermentation

View full text Add to dashboard Cite

The global food production system faces several challenges, including significant environmental impacts due to traditional agricultural practices. The rising demands of consumers for food products that are safe, healthy, and have animal welfare standards have led to an increased interest in alternative proteins and the development of the cellular agriculture field. Within this innovative field, precision fermentation has emerged as a promising technological solution to produce proteins with reduced ecological footprints. This review provides a summary of the environmental impacts related to the current global food production, and explores how precision fermentation can contribute to address these issues. Additionally, we report on the main animal-derived proteins produced by precision fermentation, with a particular focus on those used in the food and nutraceutical industries. The general principles of precision fermentation will be explained, including strain and bioprocess optimization. Examples of efficient recombinant protein production by bacteria and yeasts, such as milk proteins, egg-white proteins, structural and flavoring proteins, will also be addressed, along with case examples of companies producing these recombinant proteins at a commercial scale. Through these examples, we explore how precision fermentation supports sustainable food production and holds the potential for significant innovations in the sector.

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Cellular agriculture for milk bioactive production

Cited by 4 publications

References 222 publications

A long-acting prolactin to combat lactation insufficiency

A long-acting prolactin to combat lactation insufficiency

Precision Fermentation as an Alternative to Animal Protein, a Review

Precision Fermentation as an Alternative to Animal Protein, a Review

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