“…213 5-N-Ethylisopropyl-amiloride, 212 a specific inhibitor of the Na ϩ /H ϩ antiporter, or agents that inhibit PKC 211,212 abolished the ET-1 induction of vascular smooth muscle alkalinization. These data suggest that ET-1 stimulates the Na ϩ /H ϩ antiporter via PKC-mediated stimulation of sodium-hydrogen exchange as has been previously shown.…”