Cells within the bulge region of mouse hair follicle transiently proliferate during early anagen: heterogeneity and functional differences of various hair cycles

Wilson, Caroline; Cotsarelis, George; Wei, Zhi; Fryer, E. Beth; MargolisFryer, Jennifer; Ostead, Matt; Tokarek, Robert; Sun, Tung Tien; Lavker, Robert M.

doi:10.1046/j.1432-0436.1994.5520127.x

Cited by 131 publications

(122 citation statements)

References 22 publications

(11 reference statements)

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“…Cells that travel upwards ultimately populate the epidermis and sebaceous glands, while cells that migrate downwards normally contribute to the regenerating hair follicle. Progenitor cells differentiate into distinct cell fates by responding to cues provided by multiple signaling molecules, which include secreted factors such as WNTs, SHH and BMP4, and transcription factors such as MYC, LEF1 and TCF3 (Kratochwil et al, 1996;Merrill et al, 2001;Millar et al, 1999;St-Jacques et al, 1998;Waikel et al, 2001;Wilson et al, 1994).…”

Section: Role Of Hr In Regulating Cell Differentiationmentioning

confidence: 99%

The co-repressor hairless has a role in epithelial cell differentiation in the skin

et al. 2004

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Although mutations in the mammalian hairless (Hr) gene result in congenital hair loss disorders in both mice and humans, the precise role of Hr in skin biology remains unknown. We have shown that the protein encoded by Hr (HR) functions as a nuclear receptor co-repressor. To address the role of HR in vivo, we generated a loss-of-function (Hr-/-) mouse model. The Hr-/- phenotype includes both hair loss and severe wrinkling of the skin. Wrinkling is correlated with increased cell proliferation in the epidermis and the presence of dermal cysts. In addition,a normally undifferentiated region, the infundibulum, is transformed into a morphologically distinct structure (utricle) that maintains epidermal function. Analysis of gene expression revealed upregulation of keratinocyte terminal differentiation markers and a novel caspase in Hr-/- skin, substantiating HR action as a co-repressor in vivo. Differences in gene expression occur prior to morphological changes in vivo, as well as in cultured keratinocytes, indicating that aberrant transcriptional regulation contributes to the Hr-/-phenotype. The properties of the cell types present in Hr-/- skin suggest that the normal balance of cell proliferation and differentiation is disrupted, supporting a model in which HR regulates the timing of epithelial cell differentiation in both the epidermis and hair follicle.

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Section: Role Of Hr In Regulating Cell Differentiationmentioning

confidence: 99%

The co-repressor hairless has a role in epithelial cell differentiation in the skin

et al. 2004

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“…Examination of follicles at early anagen revealed no detectable c-myb expression (Figure 4c). Follicular cells at this stage are undergoing DNA replication as judged by PCNA staining (data not shown), and thymidine incorporation (Wilson et al, 1994), but have not formed mature follicular structures. Telogen (rest) or catagen (regression) stage hair follicles also did not exhibit c-Myb expression (data not shown).…”

mentioning

confidence: 91%

Diverse developing mouse lineages exhibit high-level c-Myb expression in immature cells and loss of expression upon differentiation

et al. 1999

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“…The matrix is derived from long-lived epithelial stem cells located in the permanent, bulge region of the follicle (Cotsarelis et al, 1990;Oshima et al, 2001;Taylor et al, 2000). The stem cells proliferate transiently at anagen onset and otherwise remain quiescent (Wilson et al, 1994). The matrix gives rise to several different hair follicle lineages: the medulla, cortex and cuticle of the hair shaft; and the cuticle, Huxley's layer and Henle's layer of the IRS (Oshima et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

EpithelialBmpr1aregulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development

et al. 2004

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Bone morphogenetic protein (BMP) signaling is thought to perform multiple functions in the regulation of skin appendage morphogenesis and the postnatal growth of hair follicles. However, definitive genetic evidence for these roles has been lacking. Here, we show that Cre-mediated mutation of the gene encoding BMP receptor 1A in the surface epithelium and its derivatives causes arrest of tooth morphogenesis and lack of external hair. The hair shaft and hair follicle inner root sheath (IRS) fail to differentiate, and expression of the known transcriptional regulators of follicular differentiation Msx1,Msx2, Foxn1 and Gata3 is markedly downregulated or absent in mutant follicles. Lef1 expression is maintained, but nuclearβ-catenin is absent from the epithelium of severely affected mutant follicles, indicating that activation of the WNT pathway lies downstream of BMPR1A signaling in postnatal follicles. Mutant hair follicles fail to undergo programmed regression, and instead continue to proliferate, producing follicular cysts and matricomas. These results provide definitive genetic evidence that epithelial Bmpr1a is required for completion of tooth morphogenesis, and regulates terminal differentiation and proliferation in postnatal hair follicles.

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Cells within the bulge region of mouse hair follicle transiently proliferate during early anagen: heterogeneity and functional differences of various hair cycles

Cited by 131 publications

References 22 publications

The co-repressor hairless has a role in epithelial cell differentiation in the skin

The co-repressor hairless has a role in epithelial cell differentiation in the skin

Diverse developing mouse lineages exhibit high-level c-Myb expression in immature cells and loss of expression upon differentiation

EpithelialBmpr1aregulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development

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