Cells to Surgery Quiz: November 2018

Abstract

3. When comparing melanoma risk between the families in the study and the SEER database during the same time period, which of the following is true?a. The risks of melanoma in mutation-positive and mutation-negative families were higher than the SEER database, but were not significantly different from each other.b. Mutation-negative families had lower risk of melanoma than the SEER database.c. Mutation-positive families had higher risk of melanoma than mutation-negative families and that of the SEER database, with earlier age of onset and more affected individuals.d. There was a significantly lower risk of second melanoma in the families when compared to the risk of the general population in SEER.e. Incidence curves for both the mutation-positive and mutation-negative families were similar to the SEER database, and there was no difference in risk.