Cells involved in nerve regeneration in the cochlea

Abstract

Otolaryngology-Head and Neck Surgery August T999 Conclusion: The findings suggest that FN may provide an important role in guiding cochlear neurons during the terminal innervation events of development. This expands on previous work (Woolf et al. Dev Brain Res 1992;65:21-33) that demonstrated the transient expression of FN beneath hair cells in the developing cochlea. It also appears that NT-3, but not GDNF, is involved in cochlear neurite pathfinding as well. Future investigations will focus on SG response to patterned arrangements of FN and other substrata components as well as to other stimulatory and inhibitory growth factors. Clinical Significance: These findings have implications in auditory neurite development and regeneration. Continued work in this arena will provide clues to enhancing the growth of inner ear neuronal processes. Such information may enhance techniques that promote neuronal growth and regeneration into cochlear prostheses.