Cells, cytokines and cellular immunity in the pathogenesis of fibroproliferative vasculopathies

Mitra, Amit; Core, Michael G. Del; Agrawal, Devendra K.

doi:10.1139/y05-080

Cited by 21 publications

(14 citation statements)

References 151 publications

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“…Several lines of evidence indicate that initial interactions of blood-borne cells with metal surfaces of stents initiates a pro-inflammatory and pro-thrombotic cascades that largely contribute to the subsequent neointimal growth by creating a persistent, positive feedback mechanism of cell recruitment, intimal migration, and proliferation supported by the cytokines and growth factors released by the stent-associated cells[7-10]. To this end, researchers have focused on diminishing inflammatory cell binding to the stents[11-13].…”

Section: Introductionmentioning

confidence: 99%

Enhanced biocompatibility of CD47-functionalized vascular stents

et al. 2016

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The effectiveness of endovascular stents is hindered by in-stent restenosis (ISR), a secondary re-obstruction of treated arteries due to unresolved inflammation and activation of smooth muscle cells in the arterial wall. We previously demonstrated that immobilized CD47, a ubiquitously expressed transmembrane protein with an established role in immune evasion, can confer biocompatibility when appended to polymeric surfaces. In present studies, we test the hypothesis that CD47 immobilized onto metallic surfaces of stents can effectively inhibit the inflammatory response thus mitigating ISR. Recombinant CD47 (recCD47) or a peptide sequence corresponding to the Ig domain of CD47 (pepCD47), were attached to the surfaces of both 316L-grade stainless steel foils and stents using bisphosphonate coordination chemistry and thiol-based conjugation reactions to assess the anti-inflammatory properties of CD47-functionalized surfaces. Initial in vitro and ex vivo analysis demonstrated that both recCD47 and pepCD47 significantly reduced inflammatory cell attachment to steel surfaces without impeding on endothelial cell retention and expansion. Using a rat carotid stent model, we showed that pepCD47-functionalized stents prevented fibrin and platelet thrombus deposition, inhibited inflammatory cell attachment, and reduced restenosis by 30%. It is concluded that CD47-modified stent surfaces mitigate platelet and inflammatory cell attachment, thereby disrupting ISR pathophysiology.

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Section: Introductionmentioning

confidence: 99%

Enhanced biocompatibility of CD47-functionalized vascular stents

et al. 2016

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“…Simple manipulation of vessels during surgery alone seems to be the least likely explanation, given the absence of similar findings in several cases of multiple resections for other central nervous system (CNS) indications. Given the extensive involvement of leptomeningeal perivascular inflammation in Rasmussen encephalitis, it is more likely that known immunologic mechanisms for vascular pathology are at least partially responsible for the findings [7,8]. Possible additional evidence for this supposition includes focal mild intimal hyperplasia in several leptomeningeal vessels in a single case of a 6-year-old girl who underwent a large resection for seizures after radiation and chemotherapy treatment 2 years earlier for acute lymphocytic leukemia and subsequent herpes encephalitis.…”

Section: Discussionmentioning

confidence: 99%

Intimal thickening of meningeal arteries after serial corticectomies for Rasmussen encephalitis

Wagner¹,

Yin²,

Mathern³

et al. 2012

Human Pathology

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“…Endothelial alterations seem to be one of the most important triggering factors of infl ammation in this setting, along with release of growth factors, cytokines and especially interleukin 12. These phenomena are associated with cellular reaction that includes platelet activation and recruitment of white blood cells in the vessel wall 35,36 . Alteration of vessel structures by diabetes may initiate the infl ammatory process.…”

Section: Pathological Aspects Of Multifocal Diabetic Neuropathy (mentioning

confidence: 99%

Focal and multifocal diabetic neuropathies

Saïd

2007

Arq. Neuro-Psiquiatr.

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-Diabetic neuropathy is the most common neuropathy in industrialized countries, with a remarkable range of clinical manifestations. The vast majority of the patients with clinical diabetic neuropathy have a distal symmetrical form that progress following a fiber-length dependent pattern, with predominant sensory and autonomic manifestations. This pattern of neuropathy is associated with a progressive distal axonopathy. Patients are exposed to trophic changes in the feet, pains and autonomic disturbances. Less often, diabetic patients may develop focal and multifocal neuropathy that includes cranial nerve involvement, limb and truncal neuropathies. This neuropathic pattern tends to occur after 50 years of age, mostly in patients with longstanding diabetes mellitus. The LDDP does not show any trend to improvement and either relentlessly progresses or remain relatively stable over years. Conversely the focal diabetic neuropathies, which are often associated with inflammatory vasculopathy on nerve biopsies, remain self limited, sometimes after a relapsing course.KEY WORDS: diabetic neuropathy, diabetic ophthalmoplegia, proximal diabetic neuropathy, neuropathology, nerve biopsy. Neuropatia diabética focal e multifocalRESUMO -A neuropatia diabética é a mais predominante das neuropatias nos países industrializados apresentando uma gama variável de manifestações clinicas. A maioria dos pacientes com neuropatia diabética apresenta uma forma simétrica distal que progride para um padrão fibra comprimento dependente com manifestações sensitivas e autonomicas. Este tipo de neuropatia é associado com uma axonopatia distal progressiva. Os pacientes apresentam modificações tróficas nos pés, dores e distúrbios autonômicos. Menos freqüentemente os pacientes diabéticos podem desenvolver neuropatia focal e multifocal que incluem envolvimento de nervos cranianos, tronco e membros inferiores. Este padrão de neuropatia é mais freqüente em pacientes com mais de 50 anos e com longa historia de diabetes. Este tipo de neuropatia fibra-comprimento dependente não apresenta melhora, progride lentamente ou permanece estável por vários anos. As neuropatias focais que são associadas freqüentemente com vasculopatias inflamatórias nas biópsias de nervo, permanecem auto limitadas por vezes com surtos de remissão. PALAVRAS-CHAVE: neuropatia diabética, oftalmoplegia diabética, neuropatia proximal diabética, neuropatologia, biopsia de nervo. Prof. Diabetes mellitus is the most common cause of neuropathy in the world and an increasing burden in countries where obesity prevalence progresses. Most clinical manifestations of diabetic neuropathy had been identifi ed during the second half of the nineteenth century, but our knowledge on the pathology of diabetic neuropathies has been increased by the unexpected fi nding of infl ammatory lesions in focal diabetic neuropathies.Given that diabetes affects approximately 246 million people worldwide, it is estimated that 20-30 million people worldwide are affected by symptomatic diabetic neuropathy. G...

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Cells, cytokines and cellular immunity in the pathogenesis of fibroproliferative vasculopathies

Cited by 21 publications

References 151 publications

Enhanced biocompatibility of CD47-functionalized vascular stents

Enhanced biocompatibility of CD47-functionalized vascular stents

Intimal thickening of meningeal arteries after serial corticectomies for Rasmussen encephalitis

Focal and multifocal diabetic neuropathies

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